An elusive receptor is finally caught: P2Y12, an important drug target in platelets

Trends in Pharmacological Sciences

Volumn 22, Issue 8, 2001, Pages 388-391

  Barnard, Eric A ^a   Simon, Joseph ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ION CHANNEL; PURINE P2X RECEPTOR; PURINE P2Y RECEPTOR; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR;

CHEMICAL STRUCTURE; DRUG TARGETING; HUMAN; KNOCKOUT GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; RECEPTOR GENE; SHORT SURVEY; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

EID: 0035424765     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01759-4     Document Type: Review

References (37)

1. The regulation of vascular function by P2 receptors: Multiple sites and multiple receptors
2. Multiple P2 receptor subtypes on platelets: A new interpretation of their function
3. Cloning and functional expression of a brain G protein-coupled ATP receptor
4. Expression cloning of an ATP receptor from mouse neuroblastoma cells
5. Nucleotide receptors in the nervous system: An abundant component using diverse transduction mechanisms
6. 1 purinoceptor
7. Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation
8. Pharmacology of cloned P2X receptors
9. 1 receptors: Evidence for separate receptors stimulated by ATP and ADP on human platelets
10. 1 receptor: Similarities to the platelet ADP receptor
11. T receptor in brain capillary endothelial cells
12. 2T receptors
13. Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adenosine 5′-diphosphate (ADP) in human platelets
14. 1 purinoceptors with α,β-methylene ATP
15. 1 receptor due to deletion of a single amino acid residue
16. 1-deficient mice
17. 1 receptor-null mice
18. q-deficient mice
19. P2Y receptors: In the middle of the road
20. Identification of the platelet ADP receptor targeted by antithrombotic drugs
21. ADP is the cognate ligand for the orphan G-protein coupled receptor SP1999
22. A G protein-coupled receptor for UDP-glucose
23. 3 receptor
24. 5
25. Recombinant P2Y receptors: The UCL experience
26. 1 purinergic receptor in the human brain: Striking neuronal localization
27. 1 purinergic receptor in neurons and glial cells of the central nervous system
28. ATP, a partial agonist of atypical P2Y purinoceptors in rat brain microvascular endothelial cells
29. The P2Y purinoceptors in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase
30. Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase
31. Differences between natural and recombinant G protein-coupled receptor systems with varying receptor/G protein stochiometry
32. 1 receptor
33. 2+ channel in neurones, with both adenosine triphosphates and diphosphates as potent agonists
34. Adenosine 5-diphosphate antagonists and human platelets: No evidence that aggregation and inhibition of stimulated adenylate cyclase are mediated by different receptors
35. Characterization of putative P2T receptor endogenously expressed in rat glioma and brain microvascular endothelial cells
36. 3) activated preferentially by nucleoside diphosphatases
37. A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleotide triphosphates