Recombinant P2Y receptors: The UCL experience

Journal of the Autonomic Nervous System

Volumn 81, Issue 1-3, 2000, Pages 164-170

  King, Brian F ^a   Townsend Nicholson, Andrea ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

ATP; Expression; GPCR; Metabotropic receptor; P2Y receptor; P2Y subtype; Recombinant

Indexed keywords

PURINE P2 RECEPTOR; RECOMBINANT RECEPTOR;

CELL COMMUNICATION; CELL SURFACE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; UNITED STATES;

EID: 0034601226     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(00)00134-X     Document Type: Article

References (29)

1. Bogdanov Y.D., Dale L., King B.F., Whittock N., Burnstock G. Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos. J. Biol. Chem. 272:1997;12583-12590.
2. Bogdanov Y., Rubino A., Burnstock G. Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart. Life Sci. 62:1998;697-703.
3. 4 nucleotide receptor. Br. J. Pharmacol. 124:1998;428-430.
4. Charlton S.J., Brown C.A., Weisman G.A., Turner J.T., Erb L., Boarder M.R. PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br. J. Pharmacol. 118:1996;704-710.
5. Communi D., Pirotton S., Parmentier M., Boeynaems J.M. Cloning and functional expression of a human uridine nucleotide receptor. J. Biol. Chem. 270:1995;30849-30852.
6. Dainty I.A., Pollard C.E., Roberts S.M., Franklin M., McKechnie K.C.W., Leff P. Evidence for subdivision of P2U-purinoceptors based on suramin sensitivity. Br. J. Pharmacol. 112:1994;578P.
7. Filippov A.K., Webb T.E., Barnard E.A., Brown D.A. Inhibition by heterologously-expressed P2Y nucleotide receptors of N-type calcium currents in rat sympathetic neurones. Br. J. Pharmacol. 121:1997;849-851.
8. 1 receptor: similarities to the platelet ADP receptor. Mol. Pharmacol. 53:1998;727-733.
9. Herzog H., Darby K., Hort Y.J., Shine J. Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene. Genome Res. 6:1996;858-861.
10. 5 receptor. Biochem. Biophys. Res. Commun. 236:1997;106-112.
11. 1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J. Biol. Chem. 273:1998;2030-2034.
12. Kaplan M.H., Smith D.I., Sundick R.S. Identification of a G protein coupled receptor induced in activated T cells. J. Immunol. 151:1993;628-636.
13. King B.F., Burnstock G. Molecular biology of purinoceptors: characterisation of a family of G protein-coupled recombinant P2Y purinoceptors derived from brain tissue. Proc. Eur. Congr. Clin. Neuropharmacol. 1:1994;36P.
14. King B.F., Townsend-Nicholson A., Burnstock G. Metabotropic receptors for ATP and UTP: exploring the correspondence between native and recombinant nucleotide receptors. Trends Pharmacol. Sci. 19:1998;506-514.
15. Li Q., Schachter J.B., Harden T.K., Nicholas R.A. The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. Biochem. Biophys. Res. Commun. 236:1997;455-460.
16. 6 receptor. Mol. Pharmacol. 54:1998;541-546.
17. Lustig K.D., Shiau A.K., Brake A.J., Julius D. Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc. Natl. Acad. Sci. USA. 90:1993;5113-5117.
18. Marchese A., George S.R., Kolakowski L.F. Jr., Lynch K.R., O'Dowd B.F. Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends Pharmacol. Sci. 20:1999;370-375.
19. 1 suggests a role for nucleotide signalling in development of the chick embryo. Dev. Dyn. 214:1999;152-158.
20. Nguyen T., Erb L., Weisman G.A., Marchese A., Heng H.H., Garrad R.C., George S.R., Turner J.T., O'Dowd B.F. Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. J. Biol. Chem. 270:1995;30845-30848.
21. 1 receptor. Mol. Pharmacol. 54:1998;1118-1123.
22. Ralevic V., Burnstock G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:1998;413-492.
23. Simon J., Webb T.E., King B.F., Burnstock G., Barnard E.A. Characterisation of a recombinant P2Y purinoceptor. Eur. J. Pharmacol. 291:1995;281-289.
24. Webb T.E., Simon J., Krishek B.J., Bateson A.N., Smart T.G., King B.F., Burnstock G., Barnard E.A. Cloning and functional expression of a brain G-protein-coupled ATP receptor. FEBS Lett. 324:1993;219-225.
25. Webb T.E., Boluyt M.O., Barnard E.A. Molecular biology of P2Y purinoceptors: expression in rat heart. J. Auton. Pharmacol. 16:1996;303-307.
26. 3) activated preferentially by nucleoside diphosphates. Mol. Pharmacol. 50:1996;258-265.
27. 5. Biochem. Biophys. Res. Commun. 219:1996;105-110.
28. 4 receptor. J. Neurochem. 71:1998;1348-1357.
29. Ziganshin A.U., Hoyle C.H., Lambrecht G., Mutschler E., Bumert H.G., Burnstock G. Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood vessels. Br. J. Pharmacol. 111:1994;923-929.