Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis

Human Gene Therapy

Volumn 12, Issue 8, 2001, Pages 905-920

  Poliani, P L ^a   Brok, H ^b   Furlan, R ^a   Ruffini, F ^a   Bergami, A ^a   Desina, G ^a   Marconi, P C ^c   Rovaris, M ^a   Uccelli, A ^d   Glorioso, J C ^e   Penna, G ^f   Adorini, L ^f   Comi, G ^a   'T Hart, B ^b   Martino, G ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^c UNIVERSITY OF FERRARA   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f ROCHE MILANO RICERCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VIRUS VECTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CONTROLLED STUDY; DEMYELINATION; EPENDYMA CELL; GENE; GENE THERAPY; HERPES SIMPLEX VIRUS 1; INFLAMMATORY INFILTRATE; MALE; NECROSIS; NERVE FIBER DEGENERATION; NONHUMAN; RHESUS MONKEY; SPINAL CORD; VIRUS REPLICATION;

ANIMALS; AUTOIMMUNE DISEASES; BLOOD-BRAIN BARRIER; BRAIN; CELL DIVISION; CENTRAL NERVOUS SYSTEM; CHEMOKINE CCL2; CYTOKINES; DOWN-REGULATION; ENCEPHALOMYELITIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; HUMANS; INTERLEUKIN-4; MACACA MULATTA; MAGNETIC RESONANCE IMAGING; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; T-LYMPHOCYTES; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

ALPHAVIRUS; ANIMALIA; DNA VIRUSES; HERPES; HUMAN HERPESVIRUS 1; MACACA MULATTA;

EID: 0034919042     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303401750195872     Document Type: Article

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