Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA

Journal of Immunology

Volumn 160, Issue 2, 1998, Pages 936-942

  Nishimura, Hitoshi ^a   Washizu, Junji ^a   Nakamura, Nobuhisa ^a   Enomoto, Atsushi ^a   Yoshikai, Yasunobu ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CODON; EXON; GENETIC TRANSCRIPTION; INTRON; MOLECULAR CLONING; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PERITONEUM MACROPHAGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; QUANTITATIVE DIAGNOSIS; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; RNA TRANSLATION; SALMONELLA; TOXOPLASMA GONDII;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; EXONS; INTERLEUKIN-15; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0031974726     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Grabstein, K. H., J. Eisenmann, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, L. Johnson, M. R. Alderson, J. D. Watson, D. M. Anderson, and J. G. Giri. 1994. Cloning of a T-cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 246:965.
2. Bamford, R. N., A. J. Grant, J. D. Burton, C. Peters, G. Kurys, C. K. Goldman, J. Brennan, E. Roessler, and T. A. Waldmann. 1994. The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91:49.
3. Giri, J. G., M. Ahdieh, J. Eisenman, K. Shanebeck, K. Grabstein, S. Kumaki, A. Namen, L. S. Park, D. Cosman, and D. Anderson. 1994. Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 14:3654.
4. Nishimura, H., K. Hiromatsu, N. Kobayashi, K. Grabstein, R. Paxton, K. Sugamura, J. A. Bluestone, and Y. Yoshikai. 1996. IL-15 is a novel growth factor for murine γδ T cells induced by Salmonella infection. J. Immunol. 156:663.
5. Carson, W. E., J. G. Giri, M. J. Lindemann, M. L. Linett, M. Ahdieh, R. Paxton, D. Anderson, J. Eisenmann, K. Grabstein, and M. A. Caligiuri. 1994. Interleukin (IL)-15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:1395.
6. Armitage, R. J., B. M. Macduff, J. Eisenman, R. Paxton, and K. H. Grabstein. 1995. IL-15 has stipulatory activity for the induction of B cell proliferation and differentiation. J. Immunol. 154:483.
7. Anderson, D. M., L. Johnson, M. B. Glaccum, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, V. Valentine, M. N. Kirstein, D. N. Shapiro, S. Morris, K. Grabstein, and D. Cosman. 1995. Chromosomal assignment and genomic structure of IL-15. Genomics 25:701.
8. Doherty, T. M., R. A. Seder, and A. Sher. 1996. Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156:735.
9. Flamand, L., I. Stefanescu, and J. Menezes. 1996. Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J. Clin. Invest. 97:1373.
10. Bamford, R. N., A. P. Battiata, J. D. Burton, H. Sharma, and T. A. Waldmann. 1996. IL-15/T production by the adult T-cell leukemia cell line HuT-102 is associated with an HTLV-I-R/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation. Proc. Natl. Acad. Sci. USA 93:2897.
11. Nishimura, H., M. Emoto, K. Hiromatsu, S. Yamamoto, K. Mastura, H. Gomi, T. Ikeda, S. Itohara, and Y. Yoshikai. 1995. The role of γ δ T cells in priming macrophages to produce tumor necrosis factor-α. Eur. J. Immunol. 25:1465.
12. Saiki, R. K., D. H. Gelfand, S. Stoffel, S. J. Schartf, R. Higuchi, G. T. Horn, K. B. Mullis, and H. A. Erlich. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487.
13. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
14. Laemmli, U. K. 1970. Cleavage of structual proteins during the assesmbly of the head of bacteriophage T4. Nature 227:680.
15. McGeoch, D. J. 1985. On the predictive recognition of signal peptide sequences. Virus Res. 3:271.
16. von Heijne, G., and C. Blomberg. 1979. Transmembrane translocation of proteins: the direct transfer model. Eur. J. Biochem. 97:175.
17. Meazza, R., S. Verdiani, R. Biassoni, M. Coppolecchia, A. Gaggero, A. Orengo, M. P. Colombo, B. Azzarone, and S. Ferrini. 1996. Identification of a novel interleukin-15(IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines. Oncogene 12:2187.
18. Green, M. R. 1991. Biochemical mechanisms of constitutive and regulated premRNA splicing. Annu. Rev. Cell. Biol. 7:559.
19. Padgett, R. A., P. J. Graboswi, M. M. Konarska, S. Seiler, and P. A. Sharp. 1986. Splicing of messenger RNA precursor. Annu. Rev. Biochem. 55:1119.
20. Smith, C. W., J. G. Patton, and B. Nadal-Ginard. 1989. Alternative splicing in the control of gene expression. Annu. Rev. Genet. 23:527.
21. Borsi, L., E. Balza, B. Gaggero, G. Allemanni, and L. Zardi. 1995. The alternative splicing pattern of the Tenascin-C pre-mRNA is controlled by the extracellular pH. J. Biol. Chem. 270:6243.
22. Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125.
23. Onu, A., T. Pohl, H. Krause, and S. Bulfone-Paus. 1997. Regulation of IL-15 secretion via the leader peptide of two IL-15 isoform. J. Immunol. 158:255.
24. Singer, I. I., S. Scott, G. L. Hall, G. Limjuco, J. Chin, and J. A. Schmidt. 1988. Interleukin 1b is localized in the cytoplasmic ground substance but is largely absent from the Golgi apparatus and plasma membranes of stimulated human monocytes. J. Exp. Med. 167:389.
25. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, K. Akira, M. Namba, F. Tanabe, K. Konishi, S. Fukuda, and M. Kurimoto. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88.
26. Bazan, J. F., J. C. Timans, and R. A. Kastelein. 1996. A newly defined interleukin-1? Nature 379:591.