Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway

Cancer Research

Volumn 60, Issue 19, 2000, Pages 5376-5381

  Wang, Z ^a   Kyo, S ^a   Takakura, M ^a   Tanaka, M ^a   Yatabe, N ^a   Maida, Y ^a   Fujiwara, M ^a   Hayakawa, J ^a   Ohmichi, M ^a   Koike, K ^a   Inoue, M ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; ESTROGEN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROGESTERONE; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; ENDOMETRIUM CANCER; ENZYME ACTIVATION; ENZYME SUBUNIT; ESTROGEN ACTIVITY; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSACTIVATION;

BREAST NEOPLASMS; DRUG INTERACTIONS; ENDOMETRIAL NEOPLASMS; ESTRADIOL; ESTRADIOL ANTAGONISTS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN; MAP KINASE SIGNALING SYSTEM; MEDROXYPROGESTERONE; PROGESTATIONAL HORMONES, SYNTHETIC; PROGESTERONE; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TELOMERASE; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0034307337     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Telomeres shorten during ageing of human fibroblasts
2. Chromosome first aid
3. Origin of concatemeric T7 DNA
4. TRF2 protects human telomeres from end-to-end fusions
5. Specific association of human telomerase activity with immortal cells and cancer
6. A survey of telomerase activity in human cancer
7. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
8. Telomerase activity in human ovarian carcinoma
9. The RNA component of human telomerase
10. A mammalian telomerase-associated protein
11. TLP I: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family
12. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
13. Telomerase catalytic subunit homologs from fission yeast and human
14. Expression of human telomerase subunits and correlation with telomerase activity in urothelial cancer
15. hTERT is a critical determinant of telomerase activity in renal-cell carcinoma
16. Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer
17. Human telomerase reverse transcriptase as a critical determinant of telomerase activity in normal and malignant endometrial tissues
18. Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors
19. Extension of life-span by introduction of telomerase into normal human cells
20. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
21. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
22. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
23. Telomerase activity in human endometrium
24. Expression of telomerase activity in human endometrium is localized to epithelial glandular cells and regulated in a menstrual phase-dependent manner correlated with cell proliferation
25. Telomerase is activated in the prostate and seminal vesicles of the castrated rat
26. Constitutive telomerase activity in cells with tissue-renewing potential from estrogen-regulated rat tissues
27. Estrogen activates telomerase
28. Hormonal chemoprevention of cancer in women
29. Identification of sequences in c-myc mRNA that regulate its steady-state levels
30. Expression of p21(Cip1/Waf1/Sdi1) and p27(Kip1) cyclin-dependent kinase inhibitors during human hematopoiesis
31. Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone: Evidence for the involvement of protein kinase C
32. 1 arrest and induces apoptosis in human cancer cells
33. 2 arrest after DNA damage
34. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
35. Phosphatidylinositol 3-kinase activity is important for progesterone-induced Xenopus oocyte maturation
36. Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor
37. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
38. Growth arrest of immortalized human keratinocytes and suppression of telomerase activity by p21(WAF1) gene expression
39. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
40. Adenoviral expression of p53 repression telomerase activity through down-regulation of human telomerase reverse transcriptase transcription
41. Biphasic regulation of breast cancer cell growth by progesterone: Role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1)
42. The steroid and thyroid hormone receptor superfamily
43. The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex
44. Epidermal growth factor regulates p21(ras) through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
45. Transcriptional regulation by extracellular signals: Mechanisms and specificity
46. ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry
47. Tyrosine kinase/p21(ras)/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells
48. Roles for basal and stimulated p21(Cip-1/WAF1/MDA6) expression and mitogen-activated protein kinase signaling in radiation-induced cell cycle checkpoint control in carcinoma cells
49. 1 phase
50. Telomerase activity: A biomarker of cell proliferation, not malignant transformation
51. Telomerase regulation during entry into the cell cycle in normal human T cells
52. Localization of apoptotic cells within the human endometrium and correlation between apoptosis and p21 expression