N-Acetylcysteine protects lymphocytes from nitrogen mustard-induced apoptosis

Biochemical Pharmacology

Volumn 51, Issue 9, 1996, Pages 1123-1129

  Weltin, D ^a   Aupeix, K ^a   Iltis, C ^a   Cuillerot, J M ^a   Dufour, P ^a   Marchal, J ^b   Bischoff, P ^a  

^a Institut d'Hematologie et d'Immunologie   (France)

^b INSTITUT CHARLES SADRON   (France)

Author keywords

apoptosis; lymphocytes; N acetylcysteine; nitrogen mustard; poly(ADP ribose) polymerase

Indexed keywords

ACETYLCYSTEINE; ALKYLATING AGENT; ANTIOXIDANT; CHLORMETHINE; CONCANAVALIN A; DNA FRAGMENT; ENZYME INHIBITOR; ETHIDIUM BROMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENANTHRIDINONE; PROPIDIUM IODIDE; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; AGAR GEL ELECTROPHORESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; LYMPHOCYTE; MICROSCOPY; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

EID: 0030010223     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)83389-2     Document Type: Article

References (27)

1. Ameisen JC, Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer. AIDS 8: 1197-1213, 1994.
2. Mountz JD, Zhou T, Wang W, Su X and Cheng J, Regulation of apoptosis in immune cells. J Clin Immunol 15: 1-16, 1995.
3. Umansky SR, Apoptotic process in the radiation-induced death of lymphocytes. In: Apoptosis: the Molecular Basis of Cell Death (Eds. Tomei LD and Cope FO), pp. 193-208, Cold Spring Harbor Laboratory Press, New York, 1991.
4. Kroemer G and Martinez-AC, Pharmacological inhibition of programmed lymphocyte death, Immunol Today 15: 235-242, 1994.
5. O'Connor PM, Wassermann K, Sarang M, Magrath I, Bohr WA and Kohn KW, Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard. Cancer Res 51: 6550-6557, 1991.
6. Pette M, Gold R, Pette DF, Hartung HP and Toyka KV, Mafosfamide induces DNA fragmentation and apoptosis in human T-lymphocytes - a possible mechanism for its immunosuppression action. Immunopharmacology 30: 59-69, 1995.
7. Althaus FR and Richter C, ADP-ribosylations of proteins. In: Molecular Biology Biochemistry and Biophysics (Ed. Solioz M). Springer, Berlin, 1987.
8. Weltin D, Marchal J, Dufour P, Potworowski E, Oth D and Bischoff P, Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose)polymerase, on cultured tumor cells. Oncol Res 6: 399-403, 1994.
9. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F and Ricardi C, A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Meth 139: 271-276, 1991.
10. Perandones CE, Illera VA, Pecknam D, Stunz LL and Ashman RF, Regulation of apoptosis in vitro in mature murine spleen T cells. J Immunol 151: 3521-3529, 1993.
11. Cleaver JE and Morgan WF, Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage. Mutat Res 257: 1-18, 1991.
12. Berger NA and Berger SJ, Metabolic consequences of DNA damage: the role of poly(ADP-ribose) polymerase as mediator of the suicide response. In: ADP-ribosylation, DNA Repair and Cancer (Eds. Miwa M, Hayaishi O, Shall S, Smulson M and Sugimura T), pp. 357-363. Japan Scientific Societies Press, Tokyo, 1983.
13. Nosseri C, Coppola S and Ghibelli L, Possibly involvement of poly(ADP-ribosyl)polymerase in triggering stress-induced apoptosis. Exp Cell Res 212: 367-373, 1994.
14. Banasik M, Komura H, Shimoyama M and Ueda K. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosy)transferase. J Biol Chem 267: 1569-1575, 1992.
15. Ostermann-Golkar S, Ehrenberg L, Segerbä D and Hällström I, Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor. Mutat Res 34: 1-10, 1976.
16. Barbin A and Bartsch H, Nucleophilic selectivity as a determinant of carcinogenic potency (TD50) in rodents: a comparison of mono and bi functional alkylating agents and vinyl chloride metabolites. Mutat Res 215: 95-106, 1989.
17. Staal FJT, Roederer M and Herzenberg LA, Intracellular thiols regulate activation of nuclear factor kB and transcription of human immunodefficiency virus. Proc Natl Acad Sci USA 87: 9943-9947, 1990.
18. Gmünder H, Eck HP, Benninghoff B, Roth S and Dröge W, Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine. Cell Immunol 129: 32-46, 1990.
19. Hoshino J, Koeppel C and Westhäuser E, 3-Aminobenzamide enhances dexamethasone-mediated mouse thymocyte depletion in vivo: implication for a role of polyADP-ribosylation in the negative selection of immature thymocytes. Biochem Biophys Acta 1201: 516-522, 1994.
20. Langley RE, Palayoor ST, Coleman NC and Bump EA, Modifiers of radiation-induced apoptosis. Radiat Res 136: 320-326, 1993.
21. Spotheim-Maurizot M, Gamier F, Kieda C, Sabattier R and Charlier M, N-Acetylcysteine and captopril protect DNA and cells against radiolysis by fast neutrons. Radiat Environ Biophys 32: 337-343, 1993.
22. Dorr RT and Lagel K, Effect of sulhydryl compounds and gluthatione depletion on rat heart myocyte toxicity induced by 4-hydroperoxycyclophosphamide and acrolein in vitro. Chem Biol Interact 93: 117-128, 1994.
23. Held KD and Biaglow JE, Mechanisms for the oxygen radical-mediated toxicity of various thiol-containing compounds in cultured mammalian cells. Radiat Res 139: 15-23, 1994.
24. Prescott LF and Critchley JAJH, The treatment of acetaminophen poisoning. Ann Rev Pharmacol Toxicol 23: 87-101, 1983.
25. Suter PM, Domenighetti G, Schaller MD, Laverrière MC, Ritz R and Perret C, N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controled clinical study. Chest 105: 190-194, 1994.
26. Van den Broeke LT and Beijersbergen van Henegouwen GMJ, Topically applied N-acetylcysteine as a protector against UVB-induced systemic immunosuppression. J Photochem Photobiol B: Biol 27: 61-65, 1995.
27. Roederer M, Staal FJT, Raju PA, Ela SW, Herzenberg LA and Herzenberg LA, Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proc Natl Acad Sci USA 87: 4884-4888, 1990.