Inverse regulation of vascular endothelial growth factor and VHL tumor suppressor gene in sporadic renal cell carcinomas is correlated with vascular growth: An in vivo study on 29 tumors

Journal of Molecular Medicine

Volumn 77, Issue 6, 1999, Pages 505-510

  Brieger, Jürgen ^a   Weidt, Eberhard J ^a   Schirmacher, Peter ^b   Störkel, Stephan ^b   Huber, Christoph ^a   Decker, H Jochen ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b NONE

Author keywords

Renal cell carcinoma; Vascular endothelial growth factor; VHL expression

Indexed keywords

MESSENGER RNA; VASCULOTROPIN;

ARTICLE; CONTROLLED STUDY; GENE MUTATION; HEMANGIOBLASTOMA; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; TUMOR VASCULARIZATION; TUMOR VOLUME; VON HIPPEL LINDAU DISEASE;

ADULT; AGED; CARCINOMA, RENAL CELL; ENDOTHELIAL GROWTH FACTORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; KIDNEY NEOPLASMS; LIGASES; LYMPHOKINES; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PROTEINS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0032773625     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001099900022     Document Type: Article

References (22)

1. 1. Latif F, Tory K, Gnarra J, Masahiro Y, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Li H, Wei MH, Chen F, Glenn G, Choyke P, Walther MM, Weng Y, Duan DSR, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Smith MA, Paslier DL, Chumakov I, Cohen D, Chinault C, Maher E, Linehan WM, Zbar B, Lerman MI (1993) Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260:1317-1320
2. 2. Los M, Jansen GH, Kaelin WG, Lips CJ M, Blijham GH, Voest EERA (1996) Expression pattern of the von Hippel Lindau protein in human tissues. Lab Invest 75:231-238
3. 3. Krumm A, Groudine M (1995) Tumor suppression and transcription elongation: the dire consequences of changing partners. Science 269:1400-1401
4. 4. Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DS, Gnarra JR, Linehan WM, et al (1994) Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91: 9700-9704
5. 5. Shweiki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845
6. 6. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW (1991) The vascular endothelial growth factor family: identification of a four molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5:1806-1814
7. 7. Kolch W, Martiny Baron G, Kieser A, Marme D, Ikeda E, Achen MG, Breier G, Risau W (1995) Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. Breast Cancer Res Treat 270:19761-19766
8. 8. Weidner N, Folkman J (1996) Tumoral vascularity as a prognostic factor in cancer. In: De-Vita V et al (eds) Important advances in oncology. Philadelphia, Lippincott-Raven, pp 167-190
9. 9. Suzuki K, Hayashi N, Miyamoto Y, Yamamoto M, Ohkawa K, Ito Y, Sasaki Y, Yamaguchi Y, Nakase H, Noda K, Enomoto N, Arai K, Yamada Y, Yoshihara H, Tujimura T, Kawano K, Yoshikawa K, Kamada T (1996) Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma. Cancer Res 3004-3009
10. 10. Takahashi A, Sasaki H, Kim SJ, Tobisu KI, Kakizoe T, Tsukamoto T, Kumamoto Y, Sugimura T, Terada M (1994) Markedly increased amounts of messenger RNAs for vascular endothelial associated factor and placenta growth factor in renal cell carcinoma associated angiogenesis. Cancer Res 54:4233-4237
11. 11. Nicol D, Hii SI, Walsh M, Teh B, Thompson L, Kennett C, Gotley D (1997) Vascular endothelial growth factor expression is increased in renal cell carcinoma. J Urol 157:1482-1486
12. 12. Wizigmann Voos S, Breier G, Risau W, Plate KH (1995) Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res 55:1358-1364
13. 13. Hawkins GA, Hoffman LM (1997) Base excision sequence scanning. A new method for rapid sequence scanning and mutation detection. Nat Biotechnol 15:803-804
14. 14. Hiopoulos O, Levy AP, Jiang C, Kaelin WG Jr, Goldberg MA (1996) Negative regulation of hypoxia-inducible genes by the von Hippel- Lindau protein. Proc Natl Acad Sci USA 93: 10595-10599
15. 15. Gnarra JR, Zhou S, Merrill MJ, Wagner JR, Krumm A, Papavassilioti E, Oldfield EH, Klausner RD, Linehan WM (1996) Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHI, tumor suppressor gene. Proc Natl Acad Sci USA 93:10589-10594
16. 16. Siemeister G, Weindel K, Mohrs K, Barleon B, Martiny-Baron G, Marmé D, Martiny Baron G, Marme D (1996) Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res 2299-2301
17. 17. Ikeda E, Achen MG, Breier G, Risau W (1995) Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 270:19761-19766
18. 18. Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ (1997) Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94:8104-8109
19. 19. Thoenes W, Störkel S, Rumpelt HJ, Moll R (1990) Cytomorphological typing of renal cell carcinoma - a new approach. Eur Urol 18 [Suppl 2]:6-9
20. 20. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning. Cold Spring Harbor Laboratory, Cold Spring Harbor
21. 21. Schirmacher P, Schauss D, Dienes HP (1996) Intracellular accumulation of incompletely processed transforming growth factor-alpha polypeptides in ground glass hepatocytes of chronic hepatitis B virus infection. J Hepatol 24:547-554
22. 22. Folkman J, D'Amore PA (1996) Blood vessel formation: what is its molecular basis? Cell 87:1153-1155