Interaction of c-myc with transforming growth factor a and hepatocyte growth factor in hepatocarcinogenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 376, Issue 1-2, 1997, Pages 221-234

  Thorgeirsson, Snorri S ^a   Santoni Rugiu, Eric ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Carcinogenesis; Oncogene; Suppressor gene; Transgenic mouse

Indexed keywords

PHENOBARBITAL; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; LIVER CANCER; LIVER CARCINOGENESIS; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE C MYC; PRIORITY JOURNAL; SUPPRESSOR GENE; TRANSGENIC MOUSE;

ANIMALS; ANTICARCINOGENIC AGENTS; CARCINOGENS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTE GROWTH FACTOR; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; NEOPLASMS, EXPERIMENTAL; PHENOBARBITAL; PROTO-ONCOGENE PROTEINS C-MYC; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMALIA; MUS MUSCULUS;

EID: 0030977321     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00047-X     Document Type: Article

References (91)

1. Aldana, P.R., M.E. Goerke, S.C. Carr and T.F. Tracy, Jr. (1994) The expression of regenerative growth factors in chronic liver injury and repair. J. Surg. Res., 57, 711-717.
2. Aoyama, T., H.V. Gelboin and F.J. Gonzalez (1990) Mutagenic activation of 2-amino-3-methyl-imidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450. Cancer Res., 50, 2060-2063.
3. 32P-postlabeling analysis. Carcinogenesis, 8, 1589-1593.
4. Bellusci, S., G. Moens, G. Gaudino, P. Comoglio, T. Nakamura, J.-P. Thiery and J. Jouanneau (1994) Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increase tumorigenicity. Oncogene, 9, 1091-1099.
5. Bottaro, D.P., J.S. Rubin, D.L. Faletto, A.M.-L. Chan, T.E. Kmiecik, G.F. Vande Woude and S.A. Aaronson, S.A. (1991) Identification of the HGF receptor as the c-MET proto- oncogene product. Science, 251, 802-804.
6. Bursch, W., B. Lauer, I. Timmermann-Trosiener, G. Barthel, J. Schuppler and R. Schulte-Hermann (1984) Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis, 5, 453-458.
7. Bussolino, F., M.F. Di Renzo, M. Ziche, E. Bocchietto, M. Olivero, L. Naldini, G. Gaudino, L. Tamagnone, A. Coffer and P.M. Comoglio (1992) Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol., 119, 629-641.
8. Chandar, N., B. Lombardi and J. Locker (1989) c-Myc gene amplification during hepatocarcinogenesis by a choline-devoid diet. Proc. Natl. Acad. Sci. USA, 86, 2703-2707.
9. Comoglio, P.M. (1993) Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells, in: Goldberg, I.D. and E.M. Rosen (Eds.), Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and c-Met receptor, Birkhäuser, Verlag/Basel, pp. 131-165.
10. Compere, S.J., P. Baldacci and R. Jaenisch (1988) Oncogenes in transgenic mice. Biochim. Biophys. Acta, 948, 129-149.
11. DePinho, R.A., N. Schreiber-Agus and F.W. Alt (1991) Myc family oncogenes in development of normal and neoplastic cells. Adv. Cancer Res., 57, 1-46.
12. Derynck, R., D.V. Goeddel, A. Ullrich, J.U. Gutterman, R.D. Williams, T.S. Bringman and W.H. Berger (1987) Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors. Cancer Res., 47, 707-712.
13. Di Renzo, M.F., M. Olivero, S. Ferro, M. Prat, I. Bongarzone, S. Pilotti, A. Belfiore, A. Costantino, R. Vigneri, M.A. Pierotti and P.M. Comoglio (1992) Overexpression of the c-met/HGF receptor gene in human thyroid carcinomas. Oncogene, 7, 2549-2553.
14. Di Renzo, M.F., M. Olivero, A. Giacomini, H. Porte, E. Chastre, L. Mirossay, B. Nordlinger, S. Bretti, S. Bottardi, S. Giordano, M. Plebani, C. Gespach and P.M. Comoglio (1995) Overexpression and amplification of the met/HGF receptor gene during progression of colorectal cancer. Clin. Cancer Res., 1, 147-154.
15. Doll, R. and D. Peto (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst., 66, 1191-1208.
16. Ebert, M., M. Yokoyama, H. Friess, M.W. Büchler and M. Korc (1994) Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer. Cancer Res., 54, 5775-5778.
17. Evarts, R.P., H. Nakatsukasa, E.R. Marsden, Z. Hu and S.S. Thorgeirsson (1992) Expression of transforming growth factor-alpha in regenerating liver and during hepatic differentiation. Mol. Carcinog., 5, 25-31.
18. Frith, C.H., J.M. Ward and V.S. Turosov (1994) Tumors of the liver. in: Turusov, V. and U. Mohr (Eds.), Pathology of Tumours in Laboratory Animals, vol. 2, IARC Scientific Publications, Lyon, pp. 223-270.
19. Gentry, L.E., D.R. Twardzik, G.J. Lim, J.E. Ranchalis and D.C. Lee (1987) Expression and characterization of transforming growth factor α precursor protein in transfected mammalian cells. Mol. Cell. Biol., 7, 1585-1591.
20. Grant, D.S., H.K. Kleinman, I.D. Goldberg, M.M. Bhargava, B.J. Nickoloff, J.L. Kinsella, P. Polverini and E.M. Rosen (1993) Scatter factor induces blood vessel formation in vivo. Proc. Natl. Acad. Sci. USA, 90, 1937-1941.
21. Grigioni, W.F., M. Fiorentino, A. D'Errico, A. Ponzetto, T. Crepaldi, M. Prat and P.M. Comoglio (1995) Overexpression of c-met protooncogene product and raised Ki67 index in hepatocellular carcinomas with respect to benign conditions. Hepatology, 21, 1543-1546.
22. 1 mice fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ). Carcinogenesis, 11, 1005-1011.
23. Hanahan, D. (1988) Dissecting multistep tumorigenesis in transgenic mice. Ann. Rev. Genet., 22, 479-519.
24. Higashio, K., N. Shima, M. Goto, Y. Itagaki, M. Nagao, H. Yasuda and T. Morinaga (1990) Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor. Biochem. Biophys. Res. Commun., 170, 397-404.
25. Hu, Z., R.P. Evarts, K. Fujio, E.R. Marsden and S.S. Thorgeirsson (1993) Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat. Am. J. Pathol., 142, 1823-1830.
26. Hunter, T. (1991) Cooperation between oncogenes. Cell, 64, 249-270.
27. Iyer, A., T.E. Kmiecik, M. Park, I. Daar, D. Blair, K.J. Dunn, P. Sutrave, J.N. Ihle, M. Bodescot and G.F. Vande Woude (1990) Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene. Cell Growth Differ., 1, 87-95.
28. James, N.H. and R.A. Roberts (1994) The peroxisome proliferator class of nongenotoxic hepatocarcinogens synergize with epidermal growth factor to promote clonal expansion of initiated rat hepatocytes. Carcinogenesis, 15, 2687-2694.
29. Jhappan, C., C. Stahle, R.N. Harkins, N. Fausto, G.H. Smith and G.T. Merlino (1990) TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell, 61, 1137-1146.
30. Jirtle, R.L., G.R. Hankins, H. Reisenbichler and I.J. Boyer (1994) Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital. Carcinogenesis, 15, 1473-1478.
31. Jirtle, R.L. and S.A. Meyer (1991) Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-β1 expression. Dig. Dis. Sci., 36, 659-668.
32. Kato, R. (1986) Metabolic activation of mutagenic heterocyclic aromatic amines from protein pyrolysates. CRC Crit. Rev. Toxicol., 16, 307-348.
33. Kuniyasu, H., W. Yasui, H. Yokozaki, Y. Kitadai and E. Tahara (1993) Aberrant expression of c-met mRNA in human gastric carcinomas. Int. J. Cancer, 55, 72-75.
34. Lindroos, P., W.T. Tsai, R. Zarnegar and G.K. Michalopoulos (1992) Plasma levels of HGF in rats treated with tumors promoters. Carcinogenesis, 13, 139-141.
35. Lindroos, P. and G.K. Michalopoulos (1993) Response of phenobarbital- and ciprofibrate-exposed hepatocytes to growth factors in type I collagen gels. Carcinogenesis, 14, 731-735.
36. Liu, M.L., W.M. Mars and G.K. Michalopoulos (1995) Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine. Carcinogenesis, 16, 841-843.
37. Liu, C., M.S. Tsao and J.W. Grisham (1988) Transforming growth factors produced by normal and neoplastically transformed rat liver epithelial cells in culture. Cancer Res., 48, 850-855.
38. Luscher, B. and R.N. Eisenman (1990) New light on myc and myb. Part. I. Myc. Genes Dev., 4, 2025-2035.
39. Marquardt, H., M.W. Hunkapillar, L.E. Hood, D.R. Twardzik, J.E. DeLarco, J.R. Stephenson and G.J. Todaro (1983) Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor. Proc. Natl. Acad. Sci. USA, 80, 4684-4688.
40. Marquardt, H., M.W. Hunkapillar, L.E. Hood and G.J. Todaro (1984) Rat transforming growth factor type I: structure and relation to epidermal growth factor. Science, 223, 1079-1082.
41. Massague, J. (1983) Epidermal growth factor-like transforming growth factor II. Interaction with epidermal growth factor receptors on human placenta membrane and A431 cells. J. Biol. Chem., 258, 13614-13620.
42. Matsumoto, K. and T. Nakamura (1993) Roles of HGF as a pleiotropic factor in organ regeneration, in: Goldberg, I.D. and E.M. Rosen (Eds.), Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and c-Met Receptor, Verlag/Basel, Birkhäuser, pp. 225-249.
43. Michalopoulos, G.K. and R. Appasamy (1993) Metabolism of HGF-SF and its role in liver regeneration, in: Goldberg, I.D. and E.M. Rosen, Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and c-Met Receptor, Birkhäuser, Verlag/Basel, pp. 175-283.
44. Michalopoulos, G.K., K.A. Houck, M.L. Dolan and N.C. Luetteke (1984) Control of hepatocyte proliferation by two serum factors. Cancer Res., 44, 4414-4419.
45. Moroy, T., F.W. Alt and R.A. DePinho (1991) Use of transgenic mice to study normal and abnormal mammalian development, in: S. Broder et al. (Eds.), Molecular Foundation of Oncology. Williams and Wilkins, Baltimore, MD, pp. 455-487.
46. Murakami, H., N.D. Sanderson, P. Nagy, P.A. Marino, G. Merlino and S.S. Thorgeirsson (1993) Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor-α in hepatic oncogenesis. Cancer Res., 53, 1719-1723.
47. Nagy, P., R.P. Evarts, E. Marsden, J. Roach and S.S. Thorgeirsson (1988) Cellular distribution of c-myc transcripts during chemical carcinogenesis in rats. Cancer Res., 48, 5522-5527.
48. Nakamura, T., K. Nawa and A. Ichiara (1984) Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem. Biophys. Res. Commun., 122, 1450-1459.
49. Naldini, L., K.M. Weidner, E. Vigna, G. Gaudino, A. Bardelli, C. Ponzetto, R.P. Narsimhan, G. Hartmann, R. Zarnegar, G.K. Michalopoulos, W. Birchmeier and P.M. Comoglio (1991) Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 10, 2867-2878.
50. Natali, P.G., M.R. Nicotra, M.F. Di Renzo, M. Prat, A. Bigotti, R. Cavaliere and P.M. Comoglio (1993) Expression of the c-met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression. Br. J. Cancer, 68, 746-750.
51. Neveu, M.J., K.L. Babcock, E.L. Hertzberg, D.L. Paul, B.J. Nicholson and H.C. Pitot (1994) Colocalized alterations in connexin 32 and cytochrome P450IIB1/2 by phenobarbital and related liver tumor promoters. Cancer Res., 54, 3145-3152.
52. Pepper, M.S., K. Matsumoto, T. Nakamura, L. Orci and R. Montesano (1992) Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine epithelial cells. J. Biol. Chem., 267, 20493.
53. Perraud, F., W. Dalemans, J.L. Genrault, D. Dreyer, D. Ali-Hadji, T. Favre and A. Pavirani (1991) Characterization of trans-immortalized hepatic cell lines established from transgenic mice. Exp. Cell Res., 195, 59-65.
54. Prat, M., R.P. Narsimhan, T. Crepaldi, M.R. Nicotra, P.G. Natala and P.M. Comoglio (1991) The receptor encoded by the human c-met oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Int. J. Cancer, 49, 323-328.
55. Raymond, V.W., D.C. Lee, J.W. Grisham and H.S. Earp (1989) Regulation of transforming growth factor α messenger RNA expression in a chemically transformed rat hepatic epithelial cell line by phorbol ester and hormones. Cancer Res., 49, 3608-3612.
56. Ren, G.J., L.F. Hu, Y.C. Cheng and D.F. Wan (1986) Oncogenes in human primary hepatic cancer. J. Cell. Physiol. Suppl., 4, 13-21.
57. Rong, S., M. Bodescot, D. Blair, J. Dunn, T. Nakamura, K. Mizuno, M. Park, A. Chan, S. Aaronson and G.F. Vande Woude (1992) Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol. Cell. Biol., 12, 5152-5158.
58. Rong, S., L.A. Donehower, M.F. Hansen, L. Strong, M. Tainsky, M. Jeffers, J.H. Resau, E. Hudson, I. Tsarfaty and G.F. Vande Woude (1995) Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients. Cancer Res., 55, 1963-1970.
59. Rong, S., S. Segal, M. Anver, J.H. Resau and G.F. Vande Woude (1994) Invasiveness and metastasis of NIH/3T3 cells induced by Met-HGF/SF autocrine stimulation. Proc. Natl. Acad. Sci. USA, 91, 4731-4735.
60. Rosen, E.M., S.K. Nigam and I.D. Goldberg (1994) Scatter Factor and the c-Met receptor: a paradigm for mesenchymal/epithelial interaction. J. Cell Biol., 127, 1783-1787.
61. Sakaguchi, H., S. Seki, H. Tsubouchi, Y. Daikuhara, Y. Niitani and K. Kobayashi (1994) Ultrastructural location of human hepatocyte growth factor in human liver. Hepatology, 19, 1157-1163.
62. Sandgren, E.P., N.C. Luetteke, R.D. Palmiter, R.L. Brinster and D.C. Lee (1990) Overexpression of TGFa in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell, 61, 1121-1135.
63. Sandgren, E.P., C.J. Quaife, C.A. Pinkert, R.D. Palmiter and R.L. Brinster (1989) Oncogene-induced liver neoplasia in transgenic mice. Oncogene, 4, 715-724.
64. Santoni-Rugiu, E., K.H. Preisegger, A. Kiss, T. Audolfsson, G. Shiota, E.V. Schmidt and S.S. Thorgeirsson (1996) Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model. Proc. Natl. Acad. Sci. USA, 93, 9577-9582.
65. Schirmacher, P., W.A. Held, D. Yang, L. Biempica and C.E. Rogler (1991) Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tage transgenic mice. Am. J. Pathol., 139, 231-241.
66. Schmidt, C., F. Bladt, S. Goedecke, V. Brinkmann, W. Zschiesche, M. Sharpe, E. Gherardi and C. Birchmeier (1995) Scatter factor/hepatocyte growth factor is essential for liver development. Nature, 373, 699-702.
67. Schut, H.A.J., K.L. Putman and K. Randerath (1988) DNA adduct formation of the carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in target tissues of the F-344 rat. Cancer Lett., 41, 345-352.
68. Schut, H.A.J., E.G. Snyderwine, H.-X. Zu and S.S. Thorgeirsson (1991) Similar pattern of DNA adduct formation of 2-amino-3-methylimidazo[4,5-f]quinoline in the Fischer-344 rat, CDF1 mouse, cynomolgus monkey, and Salmonella typhimurium. Carcinogenesis, 12, 931-934.
69. Seglen, P.O., G. Saeterm and P.E. Schwarze (1990) Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas. Hepatology, 12, 295-300.
70. Shima, N., M. Nagao, F. Ogaki, E. Tsuda, A. Murakami and K. Higashio (1991) Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: cloning of its cDNA, purification and characterization of recombinant protein. Biochem. Biophys. Res. Commun., 180, 1151-1158.
71. Shiota, G., D.B. Rhoads, T.C. Wang, T. Nakamura and E.V. Schmidt (1992) Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc. Natl. Acad. Sci. USA, 89, 373-377.
72. Shiota, G., H. Kawasaki, T. Nakamura and E.V. Schmidt (1994a) Inhibitory effect of hepatocyte growth factor against FaO hepatocellular carcinoma cells may be associated with changes of intracellular signaling pathways mediated by protein kinase C. Res. Commun. Mol. Pathol. Pharmacol., 85, 271-278.
73. Shiota, G., T.C. Wang, T. Nakamura and E.V. Schmidt (1994b) Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression. Hepatology, 19, 962-972.
74. 3-450 of carcinogenic arylamines found in foods. J. Natl. Cancer Inst., 81, 223-227.
75. 32P-postlabeling method to detect DNA adducts of 2- amino-3-methylimidazo[4,5-f]quinoline (IQ) in monkeys fed IQ: Identification of the N-(deoxyguanosin-8-yl)-IQ adduct. Carcinogenesis, 9, 1739-1743.
76. Stoker, M., E. Gherardi, M. Perryman and J. Gray (1987) Scatter factor is a fibroblast-derived modulator of epithelial cell mobilty. Nature, 327, 239-242.
77. Strain, A., T. Ismail, H. Tsubouchi, N. Arakaki, T. Hishida, N. Kitamura, Y. Daikuhara and P. McMaster (1991) Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes. J. Clin. Invest., 87, 1853-1857.
78. Sugimura, T. and S. Sato (1983) Mutagens/carcinogens in foods. Cancer Res. (Suppl.), 43, 2415s-2421s.
79. Tajima, H., K. Matsumoto and T. Nakamura (1991) Hepatocyte growth factor has a potent anti-proliferative activity in various tumor cell lines. FEBS Lett., 291, 229-232.
80. Takagi, H., C. Jhappan, R. Sharp and G. Merlino (1992) Hypertrophic gastropathy resembling Menetrier's disease in transgenic mice overexpressing transforming growth factor alpha in the stomach. J. Clin. Invest, 90, 1161-1167.
81. Takagi, H., R. Sharp, H. Takayama, M.R. Anver, J.M. Ward and G. Merlino (1993) Collaboration between growth factors and diverse chemical carcinogens in hepatocarcinogenesis of transforming growth factor α transgenic mice. Cancer Res., 53, 4329-4336.
82. Tsao, M.S., H. Zhu, A. Giaid, J. Viallet, T. Nakamura and M. Park (1993) Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcinoma cells. Cell Growth Differ., 4, 571-579.
83. Tuczek, H.U., F.A. Grau, A. Mischlinsky, T. Wagner and G. Wegner (1985) Distribution of albumin in normal and regenerating livers of mice. Histochemistry, 83, 165-169.
84. Uehara, Y., Y. Uehara, O. Minowa, C. Mori, K. Shiota, J. Kuno, T. Noda and N. Kitamura (1995) Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature, 373, 702-705.
85. Weidner, K.M., N. Arakaki, G. Hartmann, J. Vandekerckhove, S. Weingart, H. Rieder, C. Fonatsch, H. Tsubouchi, T. Hishida, Y. Daikuhara and W. Birchmeier (1991) Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc. Natl. Acad. Sci. USA, 88, 7001-7005.
86. Weidner, K.M., M. Sachs and W. Birchmeier (1993) The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J. Cell Biol., 127, 145-154.
87. Wojta, J., T. Nakamura, A. Fabry, P. Hufnagl, R. Beckmann, K. McGrath, K and B.R. Binder (1994) Hepatocyte growth factor stimulates expression of plasminogen activator inhibitor type 1 and tissue factor in HepG2 cells. Blood, 84, 151-157.
88. Wolf, H.K., R. Zarnegar and G.K. Michalopoulos (1991) Localization of hepatocyte growth factor in human and rat tissues: an immunohistochemical study. Hepatology, 14, 488-494.
89. Wright, N.A., R. Poulsom, G.W.H. Stamp, P.A. Hall, R.E. Jeffery, M.-C. Longcroft, C. Tomasetto, P. Chambon (1990) Epidermal growth factor(EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues. J. Pathol., 162, 279-284.
90. Yaswen, P., M. Goyette, P.R. Shank and N. Fausto (1985) Expression of c-Ki-ras, c-Ha-ras and c-myc in specific cell types during hepatocarcinogenesis. Mol. Cell. Biol., 5, 780-786.
91. Zarnegar, R. and G.K. Michalopoulos (1995) The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis. J. Cell Biol., 129, 1177-1180.