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Volumn 59, Issue 3, 2001, Pages 124-130

Toll-like receptors and their signaling mechanism in innate immunity

Author keywords

Dendritic cells; Lipopolysaccharide; Myd88; Toll like receptor; Unmethylated cytosine guanosine dna

Indexed keywords

BACTERIAL DNA; CELL SURFACE RECEPTOR; CYTOKINE; DIFFERENTIATION ANTIGEN; DROSOPHILA PROTEIN; IMMUNOGLOBULIN RECEPTOR; LIPOPOLYSACCHARIDE; LIPOPROTEIN; MEMBRANE PROTEIN; MYD88 PROTEIN, DROSOPHILA; MYD88 PROTEIN, MOUSE; MYELOID DIFFERENTIATION FACTOR 88; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TEHAO PROTEIN, DROSOPHILA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5;

EID: 0035378047     PISSN: 00016357     EISSN: None     Source Type: Journal    
DOI: 10.1080/000163501750266701     Document Type: Article
Times cited : (109)

References (43)
  • 1
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996;86:973-83.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 2
    • 0030663332 scopus 로고    scopus 로고
    • The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
    • Williams MJ, Rodriguez A, Kimbrell DA, Eldon ED. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J 1997;16:6120-30.
    • (1997) EMBO J , vol.16 , pp. 6120-6130
    • Williams, M.J.1    Rodriguez, A.2    Kimbrell, D.A.3    Eldon, E.D.4
  • 3
    • 0034641738 scopus 로고    scopus 로고
    • Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
    • Tauszig S, Jouanguy E, Hoffmann JA, Imler JL. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc Natl Acad Sci USA 2000;97:10520-5.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10520-10525
    • Tauszig, S.1    Jouanguy, E.2    Hoffmann, J.A.3    Imler, J.L.4
  • 4
    • 0028965644 scopus 로고
    • Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
    • Ulevitch RJ, Tobias PS. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995;13:437-57.
    • (1995) Annu Rev Immunol , vol.13 , pp. 437-457
    • Ulevitch, R.J.1    Tobias, P.S.2
  • 5
    • 0029919991 scopus 로고    scopus 로고
    • Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
    • Haziot A, Ferrero E, Kontgen F, Hijiya N, Yamamoto S, Silver J, et al. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 1996;4:407-14.
    • (1996) Immunity , vol.4 , pp. 407-414
    • Haziot, A.1    Ferrero, E.2    Kontgen, F.3    Hijiya, N.4    Yamamoto, S.5    Silver, J.6
  • 6
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998;282:2085-8.
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3    Liu, M.Y.4    Huffel, C.V.5    Du, X.6
  • 8
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    • Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999;162:3749-52.
    • (1999) J Immunol , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6
  • 9
    • 0033458799 scopus 로고    scopus 로고
    • Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
    • Underhill DM, Ozinsky A, Smith KD, Aderem A. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Arad Sci USA 1999;96:14459-63.
    • (1999) Proc Natl Arad Sci USA , vol.96 , pp. 14459-14463
    • Underhill, D.M.1    Ozinsky, A.2    Smith, K.D.3    Aderem, A.4
  • 10
    • 0031774181 scopus 로고    scopus 로고
    • Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
    • Kirschning CJ, Wesche H, Merrill Ayres T, Rothe M. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med 1998;188:2091-7.
    • (1998) J Exp Med , vol.188 , pp. 2091-2097
    • Kirschning, C.J.1    Wesche, H.2    Merrill Ayres, T.3    Rothe, M.4
  • 11
    • 0032541661 scopus 로고    scopus 로고
    • Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
    • Yang RB, Mark MR, Gray A, Huang A, Xie MH, Zhang M, et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 1998;395:284-8.
    • (1998) Nature , vol.395 , pp. 284-288
    • Yang, R.B.1    Mark, M.R.2    Gray, A.3    Huang, A.4    Xie, M.H.5    Zhang, M.6
  • 12
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999;11:443-51.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6
  • 13
    • 0033564325 scopus 로고    scopus 로고
    • Cutting edge: Cells that carry a null allele for toll-like receptor 2 are capable of responding to endotoxin
    • Heine H, Kirschning CJ, Lien E, Monks BG, Rothe M, Golenbock DT. Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J Immunol 1999;162:6971-5.
    • (1999) J Immunol , vol.162 , pp. 6971-6975
    • Heine, H.1    Kirschning, C.J.2    Lien, E.3    Monks, B.G.4    Rothe, M.5    Golenbock, D.T.6
  • 14
    • 0034662239 scopus 로고    scopus 로고
    • Cutting edge: Repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
    • Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J Immunol 2000;165:618-22.
    • (2000) J Immunol , vol.165 , pp. 618-622
    • Hirschfeld, M.1    Ma, Y.2    Weis, J.H.3    Vogel, S.N.4    Weis, J.J.5
  • 15
    • 0025319864 scopus 로고
    • Shared actions of endotoxin and taxol on TNF receptors and TNF release
    • Ding AH, Porteu F, Sanchez E, Nathan CF. Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science 1990;248:370-2.
    • (1990) Science , vol.248 , pp. 370-372
    • Ding, A.H.1    Porteu, F.2    Sanchez, E.3    Nathan, C.F.4
  • 16
    • 5944261457 scopus 로고    scopus 로고
    • Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
    • Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000;1:398-401.
    • (2000) Nat Immunol , vol.1 , pp. 398-401
    • Kurt-Jones, E.A.1    Popova, L.2    Kwinn, L.3    Haynes, L.M.4    Jones, L.P.5    Tripp, R.A.6
  • 17
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    • Ohashi K, Burkart V, Flohe S, Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 2000;164:558-61.
    • (2000) J Immunol , vol.164 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 18
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994;12:991-1045.
    • (1994) Annu Rev Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 19
    • 0033747044 scopus 로고    scopus 로고
    • Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway
    • Basu S, Binder RJ, Suto R, Anderson KM, Srivastava PK. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway. Int Immunol 2000;12:1539-46.
    • (2000) Int Immunol , vol.12 , pp. 1539-1546
    • Basu, S.1    Binder, R.J.2    Suto, R.3    Anderson, K.M.4    Srivastava, P.K.5
  • 21
    • 0034650420 scopus 로고    scopus 로고
    • Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide- 2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
    • Takeuchi O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, et al. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide- 2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J Immunol 2000;164:554-7.
    • (2000) J Immunol , vol.164 , pp. 554-557
    • Takeuchi, O.1    Kaufmann, A.2    Grote, K.3    Kawai, T.4    Hoshino, K.5    Morr, M.6
  • 22
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan- And lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
    • Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999;274:17406-9.
    • (1999) J Biol Chem , vol.274 , pp. 17406-17409
    • Schwandner, R.1    Dziarski, R.2    Wesche, H.3    Rothe, M.4    Kirschning, C.J.5
  • 23
    • 0033168728 scopus 로고    scopus 로고
    • Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
    • Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 1999;163:1-5.
    • (1999) J Immunol , vol.163 , pp. 1-5
    • Yoshimura, A.1    Lien, E.2    Ingalls, R.R.3    Tuomanen, E.4    Dziarski, R.5    Golenbock, D.6
  • 24
    • 0033585011 scopus 로고    scopus 로고
    • Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
    • Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, Finberg RW, et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999;274:33419-25.
    • (1999) J Biol Chem , vol.274 , pp. 33419-33425
    • Lien, E.1    Sellati, T.J.2    Yoshimura, A.3    Flo, T.H.4    Rawadi, G.5    Finberg, R.W.6
  • 25
    • 0033198204 scopus 로고    scopus 로고
    • Cutting edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
    • Hirschfeld M, Kirschning CJ, Schwandner R, Wesche H, Weis JH, Wooten RM, et al. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J Immunol 1999;163:2382-6.
    • (1999) J Immunol , vol.163 , pp. 2382-2386
    • Hirschfeld, M.1    Kirschning, C.J.2    Schwandner, R.3    Wesche, H.4    Weis, J.H.5    Wooten, R.M.6
  • 27
    • 0033592748 scopus 로고    scopus 로고
    • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    • Underbill DM, Ozinsky A, Hajjar AM, Stevens A, Wilson CB, Bassetti M, et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999;401:811-5.
    • (1999) Nature , vol.401 , pp. 811-815
    • Underbill, D.M.1    Ozinsky, A.2    Hajjar, A.M.3    Stevens, A.4    Wilson, C.B.5    Bassetti, M.6
  • 28
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
    • Tokunaga T, Yamamoto H, Shimada S, Abe H, Fukuda T, Fujisawa Y, et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Cancer Inst 1984;72:955-62.
    • (1984) J Natl Cancer Inst , vol.72 , pp. 955-962
    • Tokunaga, T.1    Yamamoto, H.2    Shimada, S.3    Abe, H.4    Fukuda, T.5    Fujisawa, Y.6
  • 29
    • 0033790347 scopus 로고    scopus 로고
    • Causing a commotion in the blood: Immunotherapy progresses from bacteria to bacterial DNA
    • Krieg AM, Wagner H. Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA. Immunol Today 2000;21:521-6.
    • (2000) Immunol Today , vol.21 , pp. 521-526
    • Krieg, A.M.1    Wagner, H.2
  • 31
    • 0034698739 scopus 로고    scopus 로고
    • Immune cell activation by bacterial CpG-DNA through myeloid dilferentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF) 6
    • Hacker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H. Immune cell activation by bacterial CpG-DNA through myeloid dilferentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF) 6. J Exp Med 2000;192:595-600.
    • (2000) J Exp Med , vol.192 , pp. 595-600
    • Hacker, H.1    Vabulas, R.M.2    Takeuchi, O.3    Hoshino, K.4    Akira, S.5    Wagner, H.6
  • 33
    • 0033637315 scopus 로고    scopus 로고
    • DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
    • Chu W, Gong X, Li Z, Takabayashi K, Ouyang H, Chen Y, et al. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell 2000;103:909-18.
    • (2000) Cell , vol.103 , pp. 909-918
    • Chu, W.1    Gong, X.2    Li, Z.3    Takabayashi, K.4    Ouyang, H.5    Chen, Y.6
  • 34
    • 0032127279 scopus 로고    scopus 로고
    • Targeted disruption of the MyD88 gene results in loss of IL-1- And IL-18-mediated function
    • Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998;9:143-50.
    • (1998) Immunity , vol.9 , pp. 143-150
    • Adachi, O.1    Kawai, T.2    Takeda, K.3    Matsumoto, M.4    Tsutsui, H.5    Sakagami, M.6
  • 35
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999;11:115-22.
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 36
    • 0034655280 scopus 로고    scopus 로고
    • IL-1 receptor-associated kinase modulates host responsiveness to endotoxin
    • Swantek JL, Tsen MF, Cobb MH, Thomas JA. IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J Immunol 2000;164:4301-6.
    • (2000) J Immunol , vol.164 , pp. 4301-4306
    • Swantek, J.L.1    Tsen, M.F.2    Cobb, M.H.3    Thomas, J.A.4
  • 37
    • 0033178828 scopus 로고    scopus 로고
    • The role of dendritic cells in the induction and regulation of immunity to microbial infection
    • Reis E, Sousa C, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 1999;11:392-9.
    • (1999) Curr Opin Immunol , vol.11 , pp. 392-399
    • Reis, E.1    Sousa, C.2    Sher, A.3    Kaye, P.4
  • 39
    • 0034927975 scopus 로고    scopus 로고
    • Dendritic-cell function in Toll-like receptor-and MyD88-knockout mice
    • Kaisho T, Akira S. Dendritic-cell function in Toll-like receptor-and MyD88-knockout mice. Trends Immunol 2001;22:78-83.
    • (2001) Trends Immunol , vol.22 , pp. 78-83
    • Kaisho, T.1    Akira, S.2
  • 40
    • 0035339861 scopus 로고    scopus 로고
    • Endotoxin-induced maturation of MyD88-deficient dendritic cells
    • Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 2001;166:5688-94.
    • (2001) J Immunol , vol.166 , pp. 5688-5694
    • Kaisho, T.1    Takeuchi, O.2    Kawai, T.3    Hoshino, K.4    Akira, S.5
  • 41
    • 0031775746 scopus 로고    scopus 로고
    • Dendritic cell survival and maturation are regulated by different signaling pathways
    • Rescigno M, Martino M, Sutherland CL, Gold MR. Ricciardi- Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998;188:2175-80.
    • (1998) J Exp Med , vol.188 , pp. 2175-2180
    • Rescigno, M.1    Martino, M.2    Sutherland, C.L.3    Gold, M.R.4    Castagnoli, P.5
  • 42
    • 0033980073 scopus 로고    scopus 로고
    • The role of CpG motifs in innate immunity
    • Krieg AM. The role of CpG motifs in innate immunity. Curr Opin Immunol 2000;12:35-43.
    • (2000) Curr Opin Immunol , vol.12 , pp. 35-43
    • Krieg, A.M.1
  • 43
    • 0034610291 scopus 로고    scopus 로고
    • The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    • Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A 2000;97:13766-71.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13766-13771
    • Ozinsky, A.1    Underhill, D.M.2    Fontenot, J.D.3    Hajjar, A.M.4    Smith, K.D.5    Wilson, C.B.6


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