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Volumn 11, Issue 3, 2001, Pages 258-263

Spotting the target: Microarrays for disease gene discovery

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

EID: 0035370708     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00187-8     Document Type: Review
Times cited : (48)

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    • This study shows the outstanding quantitative data that can be obtained with array-format comparative genomic hybridization when large-insert genomic clones are arrayed. The authors are able to map constitutional deletions in the NF2 locus with high resolution and precision. The potential of this approach for disease gene discovery is evident.
    • Bruder C.E., Hirvela C., Tapia-Paez I., Fransson I., Segraves R., Hamilton G., Zhang X.X., Evans D.G., Wallace A.J., Baser M.E., et al. High resolution deletion analysis of constitutional DNA from neurofibromatosis type 2 (NF2) patients using microarray-CGH. Hum Mol Genet. 10:2001;271-282. This study shows the outstanding quantitative data that can be obtained with array-format comparative genomic hybridization when large-insert genomic clones are arrayed. The authors are able to map constitutional deletions in the NF2 locus with high resolution and precision. The potential of this approach for disease gene discovery is evident.
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    • Functional discovery via a compendium of expression profiles
    • Although this study involves expression data from yeast, it provides a valuable model for the integration of data from 300 conditions. Using this database, the authors can place eight anonymous genes into distinct functional pathways.
    • Hughes T.R., Marton M.J., Jones A.R., Roberts C.J., Stoughton R., Armour C.D., Bennett H.A., Coffey E., Dai H., He Y.D., et al. Functional discovery via a compendium of expression profiles. Cell. 102:2000;109-126. Although this study involves expression data from yeast, it provides a valuable model for the integration of data from 300 conditions. Using this database, the authors can place eight anonymous genes into distinct functional pathways.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.