Overview of regulatory cytochrome P450 enzymes of the vitamin D pathway

Steroids

Volumn 66, Issue 3-5, 2001, Pages 381-389

  Omdahl, J L ^a   Bobrovnikova, E A ^a   Choe, S ^a   Dwivedi, P P ^b   May, B K ^b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Enzyme; Gene regulation; Mutation; P450; Promoter; Steroid

Indexed keywords

CALCITRIOL; CYCLIC AMP; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; OXYGENASE; RECOMBINANT ENZYME; TRANSCRIPTION FACTOR; VITAMIN D;

BINDING SITE; BIODEGRADATION; CONFERENCE PAPER; DNA RESPONSIVE ELEMENT; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REGULATION; ESCHERICHIA COLI; GENE CONTROL; GENE EXPRESSION; GENETIC PROCEDURES; GENETIC TRANSCRIPTION; HUMAN; METABOLIC ACTIVATION; NONHUMAN; POINT MUTATION; PROMOTER REGION; REVIEW; RICKETS; SEQUENCE ANALYSIS; VITAMIN D DEFICIENCY; VITAMIN D METABOLISM; VITAMIN D RESPONSIVE ELEMENT;

AMINO ACID SEQUENCE; ANIMALS; CALCITRIOL; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; STEROID HYDROXYLASES; VITAMIN D;

EID: 0035342653     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00157-4     Document Type: Conference Paper

References (71)

1. Photosynthesis of vitamin D in the skin; effect of environmental and life-style variables
2. Current understanding of the molecular actions of vitamin D
3. Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase. A study with the mature enzyme expressed in Escherichia coli
4. Targeted inactivation of vitamin D hydroxylases in mice
5. Novel findings about 24,25-dihydroxyvitamin D; an active metabolite?
6. Regulation of rat cytochrome P450C24 (CYP24) gene expression. Evidence for functional cooperation of ras-activated ets transcription factors with the vitamin d receptor in 1,25-dihydroxyvitamin d(3)-mediated induction
7. In vitro regulation of kidney 25-hydroxyvitamin D3-hydroxylase enzyme activities by vitamin D3 metabolites. Molecular specificity and mechanism of action
8. Interaction of the parathyroid and 1,25-dihydroxyvitamin D3 in the control of renal 25-hydroxyvitamin D3 metabolism
9. Effect of parathyroid hormone-like peptides on 25-hydroxyvitamin D- 1alpha-hydroxylase activity in rodents
10. Complete structure of the human gene for the vitamin D 1alpha-hydroxylase, P450c1alpha
11. Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase
12. The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus
13. Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation
14. 3-1α-hydroxylase in the human kidney
15. Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families
16. Parathyroid hormone modulation of 25-hydroxyvitamin D3 metabolism by cultured chick kidney cells is mimicked and enhanced by forskolin
17. The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate stimulates the dephosphorylation of mitochondrial ferredoxin in cultured chick kidney cells
18. Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals
19. Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter
20. The promoter of the human 25-hydroxyvitamin D3 1alpha-hydroxylase gene confers positive and negative responsiveness to PTH, calcitonin, and 1 alpha,25(OH)2D3
21. Molecular cloning, characterization, and promoter analysis of the human 25-hydroxyvitamin D3-1alpha-hydroxylase gene
22. Structural characterization of the gene encoding rat 25-hydroxyvitamin D3 24-hydroxylase
23. Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20q13.2->q13.3
24. Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D- deficient rickets
25. Vitamin D hydroxylases
26. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes [In Process Citation]
27. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
28. Identification of a vitamin D responsive element in the promoter of the rat cytochrome P450(24) gene
29. Two vitamin D response elements function in the rat 1,25-dihydroxyvitamin D 24-hydroxylase promoter
30. Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene
31. Functional assessment of two vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase gene
32. Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene
33. Transcriptional synergism between vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) promoter
34. Repression of basal transcription by vitamin D receptor; evidence for interaction of unliganded vitamin D receptor with two receptor interaction domains in RIP13delta1
35. Interactions between intracellular signals involved in the regulation of 25-hydroxyvitamin D3 metabolism
36. Influence of a tumor promoting phorbol ester on the metabolism of 25-hydroxyvitamin D3
37. Evidence for protein kinase C involvement in the regulation of renal 25-hydroxyvitamin D3-24-hydroxylase
38. Protein kinase C is involved in 24-hydroxylase gene expression induced by 1,25(OH)2D3 in rat intestinal epithelial cells
39. Effects of 1,25-dihydroxyvitamin D3 and phorbol ester on 25-hydroxyvitamin D3 24-hydroxylase cytochrome P450 messenger ribonucleic acid levels in primary cultures of rat renal cells
40. High-resolution crystal structure of cytochrome P450cam
41. Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's
42. Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution
43. A close family resemblance; the importance of structure in understanding cytochromes P450
44. Structural alignments of P450s and extrapolations to the unknown
45. Purification and characterization of 25-hydroxyvitamin D3 1alpha-hydroxylase from rat kidney mitochondria
46. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1
47. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis
48. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 alpha-hydroxylase expressed in Escherichia coli
49. Metabolic studies using recombinant Escherichia coli cells producing rat mitochondrial CYP24. CYP24 can convert 1alpha,25-dihydroxyvitamin D3 to calcitroic acid
50. The carbon monoxide-binding pigment of liver microsomes
51. Isolation and characterization of a cytochrome P-450 from rat kidney mitochondria that catalyzes the 24-hydroxylation of 25-hydroxyvitamin D3
52. Cloning and expression of cDNA encoding 25-hydroxyvitamin D3 24-hydroxylase
53. Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA
54. Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney; its inducibility by vitamin D-3
55. Cloning and expression of the chicken 25-hydroxyvitamin D3 24-hydroxylase cDNA
56. Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27)
57. pH modulation of ligand binding to adrenal mitochondrial cytochrome P-450scc
58. Characteristics of the 25-hydroxyvitamin D3- and 1,25-dihydroxyvitamin D3-24-hydroxylase(s) from HL-60 cells
59. Induction of 25-OH-vitamin D3 24- and 23-hydroxylase activities in partially purified renal extracts from pigs given exogenous 1,25-(OH)2D3
60. 25-Hydroxyvitamin D3-23-hydroxylase, a renal enzyme in several animal species
61. Kinetic properties of 25-hydroxyvitamin
62. Evidence that 1,25-dihydroxyvitamin D3 is the physiologically active metabolite of vitamin D3
63. Vitamin D kinetics in vivo; effect of 1,25-dihydroxyvitamin D administration
64. 1alpha,25-dihydroxyvitamin D3-24-hydroxylase (CYP24) hydroxylates the carbon at the end of the side chain (C-26) of the C-24-fluorinated analog of 1alpha,25-dihydroxyvitamin D3
65. Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme
66. How similar are P450s and what can their differences teach us?
67. Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets [see comments]
68. No enzyme activity of 25-hydroxyvitamin D3 1alpha-hydroxylase gene product in pseudovitamin D deficiency rickets, including that with mild clinical manifestation
69. Fast and sensitive multiple sequence alignments on a microcomputer
70. A comprehensive set of sequence analysis programs for the VAX