1α,25-Dihydroxyvitamin D3-24-hydroxylase (CYP24) hydroxylates the carbon at the end of the side chain (C-26) of the C-24-fluorinated analog of 1α,25-dihydroxyvitamin D3

Journal of Biological Chemistry

Volumn 272, Issue 22, 1997, Pages 14115-14119

  Miyamoto, Yoichi ^a,b,c   Shinki, Toshimasa ^a   Yamamoto, Keiko ^b   Ohyama, Yoshihiko ^d   Iwasaki, Hiroshi ^c   Hosotani, Ryuzo ^c   Kasama, Toshio ^c   Takayama, Hiroaki ^e   Yamada, Sachiko ^b   Suda, Tatsuo ^a  

^a SHOWA UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c NOF Corporation   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

^e TEIKYO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CARBON; COMPLEMENTARY DNA; OXYGENASE; 24,24 DIFLUOROCALCITRIOL; 24,24-DIFLUORO-1,25-DIHYDROXYVITAMIN D3; CALCIFEDIOL; CYTOCHROME P450; DRUG DERIVATIVE; STEROID MONOOXYGENASE; VITAMIN D 24 HYDROXYLASE; VITAMIN D 24-HYDROXYLASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; ENZYME METABOLISM; ENZYME SPECIFICITY; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; FLUORINATION; GENETIC TRANSFECTION; HYDROXYLATION; KIDNEY HOMOGENATE; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT; TARGET CELL; ANIMAL; HYDROLYSIS; KIDNEY; METABOLISM;

ANIMALS; CALCIFEDIOL; CALCITRIOL; CARBON; CYTOCHROME P-450 ENZYME SYSTEM; HYDROLYSIS; KIDNEY; RATS; STEROID HYDROXYLASES;

EID: 0030611705     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.22.14115     Document Type: Article

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