Novel recombinant gonadotropins

Trends in Endocrinology and Metabolism

Volumn 12, Issue 2, 2001, Pages 72-77

  Garcia Campayo, Vicenta ^a   Boime, Irving ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; RECOMBINANT PROTEIN;

CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; GENETICS; HUMAN; INFERTILITY; MUTAGENESIS; REVIEW;

CHORIONIC GONADOTROPIN; DIMERIZATION; FOLLICLE STIMULATING HORMONE; GONADOTROPINS, PITUITARY; HUMANS; INFERTILITY; LUTEINIZING HORMONE; MODELS, MOLECULAR; MUTAGENESIS; RECOMBINANT PROTEINS;

EID: 0035292797     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(00)00338-6     Document Type: Review

References (59)

1. Catt, K.J. and Dufau, M.L. (1991) Gonadotropin hormones: biosynthesis, secretion, receptors and action. In Reproductive Endocrinology(Yen, S. and Jaffe, R., eds), pp. 105-155, WS Saunders
2. Hsueh, A.J.W. et al. (1989) Granulosa cells as hormone targets: the role of biologically active follicle-stimulating hormones in reproduction. Recent Prog. Horm. Res. 45, 209-273
3. Hodgen, G.D. and Itskovitz, J. (1988) The Physiology of Reproduction (Knobil, E. and Neill, J., eds), pp. 1995-2021, Raven Press
4. Burrow, G.N. (1991) The thyroid gland and reproduction. In Reproductive Endocrinology (Yen, S. and Jaffe, R., eds), pp. 555-575, WS Saunders
5. Pierce, J.G. and Parsons, T.F. (1981) Glycoprotein hormones: structure and function. Annu. Rev. Biochem. 50, 465-495
6. Fiddes, J.C. and Talmadge, A. (1984) Structure, expression, and evolution of the genes for the human glycoprotein hormones. Recent Prog. Horm. Res. 40, 43-78
7. Birken, S. and Canfield, R.E. (1977) Isolation and amino acid sequence of COOH-terminal fragments from the β subunit of human choriogonadotropin. J. Biol. Chem. 252, 5386-5392
8. Bousfield, G.R. et al. (1985) Demonstration of a COOH-terminal extension on equine lutropin by means of a common acid-labile bond in equine lutropin and equine chorionic gonadotropin. J. Biol. Chem. 260, 9531-9533
9. Kessler, M.J. et al. (1979) Structure and location of the O-glycosidic carbohydrate units of human chorionic gonadotropin. J. Biol. Chem. 254, 7909-7914
10. Baenziger, J.U. and Green, E.D. (1988) Pituitary glycoprotein hormone oligosaccharides: structure, synthesis and function of asparaginelinked oligosaccharides on lutropin, follitropin and thyrotropin. Biochim. Biophys. Acta 947, 287-306
11. Stockell-Hartee, A. and Renwick, A.G.C. (1992) Molecular structures of glycoprotein hormones and functions of their carbohydrate components. Biochem. J. 287, 665-679
12. Bielinska, M. and Boime, I. (1995) The glycoprotein hormone family: structure and function of the carbohydrate chains. In Glycoproteins (Vol. 29A) (Montreuil, J. et al., eds), pp. 565-587, Elsevier Science
13. Hoshina, H. and Boime, I. (1982) Combination of rat lutropin subunits occurs early in the secretory pathway. Proc. Natl. Acad. Sci. U. S. A. 79, 7649-7653
14. Magner, J.A. and Weintraub, B.D. (1982) Thyroidstimulating hormone subunit processing and combination in microsomal subfractions of mouse pituitary tumor. J. Biol. Chem. 257, 6709-6715
15. Matzuk, M.M. et al. (1988) The glycoprotein asubunit is critical for secretion and stability of the human thyrotropin β-subunit. Mol. Endrocrinol. 2, 95-100
16. Corless, C.L. et al. (1987) LH and hCG β subunits determine the rate of assembly and the oligosaccharide processing of hormone dimer in transfected cells. J. Cell. Biol. 104, 1173-1181
17. Lapthorn, AJ. et al. (1994) Crystal structure of human chorionic gonadotropin. Nature 369, 455-461
18. Wu, H. et al. (1994) Structure of the human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein. Structure 2, 545-558
19. Matzuk, M. et al. (1989) Mutagenesis and chimeric genes define determinants in the β-subunits of human chorionic gonadotropin and Iutropin for secretion and assembly. J. Cell Biol. 109, 1429-1438
20. Suganuma, N. et al. (1989) Elimination of disulfide bonds affects assembly and secretion of the human chorionic gonadotropin β-subunit. J. Biol. Chem. 264, 19302-19307
21. Chen, F. et al. (1991) Role of the invariant aspartic acid 99 of human chorionic gonadotropin β in receptor binding and biological activity. J. Biol. Chem. 266, 19357-19361
22. Matzuk, M.M. et al. (1990) The biological role of the carboxyl-terminal extension of human chorionic gonadotropin β-subunit. Endocrinology 126, 376-383
23. Kaetzel, D.M. et al. (1989) Disruption of TV-linked glycosylation of bovine luteinizing hormone β-subunit by site-directed mutagenesis dramatically increases its intracellular stability but does not affect biological activity of the secreted heterodimer. Mol. Endrocrinol. 3, 1765-1774
24. Matzuk, M.M. et al. (1989) Site-specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction. J. Biol. Chem. 264, 2409-2414
25. Sowers, J.R. et al. (1979) Metabolism of exogenous human chorionic gonadotropin in men. J. Endocrinol. 80, 83-89
26. Amin, H.K. and Hunter, W.M. (1970) Human pituitary follicle stimulating hormone distribution, plasma clearance and urinary excretion as determined by radioimmunoassay J. Endocrinol. 48, 307-317
27. Fares, F.A. et al. (1992) Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin β subunit. Proc. Natl. Acad. Sci. U. S. A. 89, 4303-4308
28. Joshi, L. et al. (1995) Recombinant thyrotropin containing a β-subunit chimera with the human chorionic gonadotropin-β carboxy-terminus is biologically active, with a prolonged plasma half-life: role of carbohydrate in bioactivity and metabolic clearance. Endocrinology 136, 3839-3848
29. Szkudlinski, M.W. et al. (1996) Engineering human glycoprotein hormone superactive analogues. Nat. Biotechnol. 14, 1257-1263
30. Galway A.B. et al. (1990) In vitro and in vivo bioactivity of recombinant human follicle-stimulating hormone and partially deglycosylated variants secreted by transfected eukaryotic cell lines. Endocrinology 127, 93-100
31. Olijve, W. et al. (1996) Molecular biology and biochemistry of human recombinant follicle stimulating hormone (Puregon). Mol. Hum. Reprod. 2, 371-382
32. Sugahara, T. et al. (1995) Biosynthesis of a biologically active single pep tide chain containing the human common α and chorionic gonadotropin β subunits in tandem. Proc. Natl. Acad. Sci. U. S. A. 92, 2041-2045
33. Parsons, T.F. and Pierce, J.G. (1979) Biologically active covalently cross-linked glycoprotein hormones and the effects of modification of the COOH-terminal region of their α subunits. J. Biol. Chem. 254, 6010-6015
34. Merz, W.E. (1979) Studies of the specific role of the subunits of choriogonadotropin for biological, immunological and physical properties of the hormone: digestion of the α-subunit with carboxypeptidase A. Eur. J. Biochem. 101, 541-553
35. Gordon, W.L. and Ward, D.N. (1985) Structural aspects of luteinizing hormone action. In Luteinizing Hormone Action and Receptors (Ascoli, M., eds), pp. 173-198, CRC Press
36. Charlesworth, M.C. et al. (1987) Inhibition of human choriotropin binding to receptor by human choriotropin α peptides: a comprehensive synthetic approach. J. Biol. Chem. 262, 13409-13416
37. Bielinska, M. et al. (1990) Site-directed mutagenesis identifies two receptor binding domains in the human chorionic gonadotropin α subunit. J. Cell. Biol. 111, 330a
38. Yoo, J. et al. (1991) Conversion of lysine 91 to methionine or glutamic acid in human choriogonadotropin α results in the loss of cAMP inducibility J. Biol. Chem. 266, 17741-17743
39. Chen, F. et al. (1992) The carboxy-terminal region of the glycoprotein hormone α-subunit: contributions to receptor binding and signaling in human chorionic gonadotropin. Mol. Endocrinol. 6, 914-919
40. Narayan, P et al. (1995) Functional expression of yoked human chorionic gonadotropin in baculovirus-infected insect cells. Mol. Endocrinol. 9, 1720-1726
41. Garcia-Campayo, V. et al. (1997) Design of stable biologically active recombinant lutropin analogs. Nat. Biotechnol. 15, 663-667
42. Sugahara, T. et al. (1996) Expression of biologically active fusion genes encoding the common α subunit and the follicle-stimulating hormone β subunit: role of linker sequence. J. Biol. Chem. 271, 10445-10448
43. Grossman, M. et al. (1997) Human thyroid stimulating hormone (hTSH) subunit gene fusion produces hTSH with increased stability and serum half-life and compensates for mutagenesisinduced defects in subunit association. J. Biol. Chem. 272, 21312-21316
44. Heikoop, J.C. et al. (1997) Structure-based design and protein engineering of intersubunit disulfide bonds in gonadotropins. Nat. Biotechnol. 15, 658-662
45. Jackson, A.M. et al. (1999) The biological action of choriogonadotropin is not dependent on the complete native quaternary interactions between the subunits. Mol. Endocrinol. 13, 2175-2188
46. Ben-Menahem, D. et al. (1997) The biologic action of single-chain choriogonadotropin is not dependent on the individual disulfide bonds of the β subunit. J. Biol. Chem. 272, 6827-6830
47. Sato, A. et al. (1997) Cystine knot of the gonadotropin α subunit is critical for intracellular behavior but not for in vitro biological activity. J. Biol. Chem. 272, 18098-18103
48. Wrighton, N.C. et al. (1996) Small peptidesas potent mimetics of the protein hormone erythropoietin. Science 273, 458-463
49. Yanofsky, S.D. et al. (1996) High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries. Proc. Natl. Acad. Sci. U. S. A. 93, 7381-7386
50. Li, B. et al. (1995) Minimization of polypeptide hormone. Science 270, 1657-1660
51. Braisted, A.C. and Wells, J.A. (1996) Minimizing a binding domain from protein A. Proc. Natl. Acad. Sci. U. S. A. 93, 5688-5692
52. Heikoop, J.C. et al. (1999) Towards minimized gonadotropins with full bioactivity Eur. J. Biochem. 261, 81-83
53. Wu, C. et al. (1996) Protein engineering of a novel constitutively active hormone-receptor complex. J. Biol. Chem. 271, 31638-31642
54. Furuhashi, M. et al. (1996) Disulfide bonds 7-31 and 59-87 of the α-subunit play a different role in assembly of human chorionic gonadotropin and lutropin. Endocrinology 137, 4196-4200
55. Grossman, M. et al. (1996) Site-directed mutagenesis of amino acids 33-44 of the common α-subunit reveals different structural requirements for heterodimer expression among the glycoprotein hormones and suggests that cyclic adenosine 3′ 5′-monophosphate production and growth promotion are potentially dissociable functions of human thyrotropin. Mol. Endocrinol. 10, 769-779
56. Kanda, M. et al. (1999) Genetic fusion of an α-subunit gene to the follicle-stimulating hormone and chorionic gonadotropin β-subunit genes: production of a bifunctional protein. Mol. Endocrinol. 13, 1873-1881
57. Ben-Menahem, D. et al. (1999) Synthesis of multisubunit domain gonadotropin complexes: a model of α/β heterodimer formation. Biochemistry 38, 15070-15077
58. Cosowsky, L. et al. (1995) The groove between the α and β-subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding. J. Biol. Chem. 270, 20011-20019
59. Moyle, W.R. et al. (1995) Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones. J. Biol. Chem. 270, 20020-20031