Site-Directed Mutagenesis of Amino Acids 33-44 of the Common α-Subunit Reveals Different Structural Requirements for Heterodimer Expression among the Glycoprotein Hormones and Suggests that Cyclic Adenosine 3′,5′-Monophosphate Production and Growth Promotion are Potentially Dissociable Functions of Human Thyrotropin

Molecular Endocrinology

Volumn 10, Issue 6, 1996, Pages 769-779

  Grossmann, Mathis ^a,e   Szkudlinski, Mariusz W ^a   Dias, James A ^b   Xia, Haiying ^c   Wong, Rosemary ^a   Puett, David ^c   Weintraub, Bruce D ^d  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b WADSWORTH CENTER   (United States)

^c University of Georgia ^*  (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRICETINAE; CRICETULUS GRISEUS; SUIDAE;

AMINO ACID; CHORIONIC GONADOTROPIN; CYCLIC AMP; FOLLITROPIN; GLYCOPROTEIN; THYROTROPIN; THYROTROPIN RECEPTOR;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GROWTH; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CELL DIVISION; CELLS, CULTURED; CHO CELLS; CHORIONIC GONADOTROPIN; CRICETINAE; CYCLIC AMP; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RATS; RECEPTORS, THYROTROPIN; RECOMBINANT PROTEINS; THYROID GLAND; THYROTROPIN;

EID: 0030013815     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.10.6.8776737     Document Type: Article

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