Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase

Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2001, Pages 834-848

  Peng, H ^a,e   Xie, W ^a   Otterness, D M ^b   Cogswell, J P ^c   McConnell, R T ^c   Carter, H L ^c   Powis, G ^d   Abraham, R T ^b   Zalkow, L H ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c GLAXOSMITHKLINE   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; STEROID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PYROLYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CDC25 PHOSPHATASE; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FLUORESCEINS; HUMANS; KINETICS; MOLECULAR STRUCTURE; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035282975     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0004401     Document Type: Article

References (49)

1. Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-α-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel
2. The structure and mechanism of protein phosphatase: Insight into catalysis and regulation
3. Protein-tyrosine phosphatases: Biological function, structural characteristics, and mechanism of catalysis
4. CDC25 is a nuclear protein required for the initiation of mitosis in human cells
5. The cdc25B phosphatase is essential for the G2/M phase transition in human cells
6. Conservation of the Chk1 checkpoint pathway in Mammals: Linkage of DNA damage to cdk regulation through cdc25
7. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
8. Cdc25A is a novel phosphatase functioning early in the cell cycle
9. Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition
10. Overexpression of CDC25A and CDC25B in head and neck cancers
11. Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas
12. Overexpression of cdc25A and cdc25B is frequent in primary nonsmall cell lung cancer but is not associated with overexpression of c-myc
13. Elevated expression of cdc25A protein phosphatase in colon cancer
14. Cdc25 cell cycle-activating phosphatase and c-Myc expression in human non-Hodgkin's lymphoma
15. CDC25 phosphatases as potential human oncogenes
16. Cdc25 cell-cycle phosphatase as a target of c-myc
17. Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation
18. Cdc25 protein phosphatases in cell proliferation
19. Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins
20. A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A
21. cdc13 protein kinase
22. Dysdiolide: A novel protein phosphatase inhibitor from Caribbean Sponge Diysidea ehterria de Laubenfels
23. Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25
24. Synthesis and phosphatase inhibitory activity of analogues of Sulfircin
25. Studies on Menadione as an inhibitor of the cdc25 phosphatase
26. Naphthoquinone analogues as inactivator of cdc25 phosphatase
27. A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors from a rational core design and random side chain variation
28. Generation of an Ugi library of phosphate mimic-containing compounds and identification of novel dual specific phosphate inhibitors
29. Beckmann rearrangement in strong acid
30. Fission of tert-butyl alkyl ketone in Schmidt reaction
31. Schmidt reaction in polyphosphoric acid. II Abnormal rearrangements of ketones
32. 18
33. The second-order Beckmann rearrangement of steroidal oximes
34. Nitrogen insertion to bicyclo[2.2.1] heptanones - The photo-Beckmann rearrangement of oximes of (+)-fenchone and (+)-camphor
35. Total synthesis of pseudoguaianolide 4. A stereoselective approach to baldulin
36. Improved Synthesis of 6-azasteroid
37. A new reaction of nitriles. I. Amides from alkenes and mononitriles
38. Steroidal derived acid as inhibitors of human Cdc25A protein phosphatase
39. CD45, A prototype for transmembrane protein tyrosine phosphatases
40. The role of CD45 in signal transduction
41. The NCI in vitro anticancer drug discovery screen: Concept, implementation, and operation
42. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
43. Reactions of B-norcholesterol
44. 3 reduction of steroidal cyclic acetals
45. Studies in the sterol group. Part XLII. The constitution of zymosterol
46. The invention free radical reactions. Part XXXV. A novel radical fission reaction of N-sulfonylthioxocarbamates
47. Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B