Dysidiolide and related γ-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, Cdc25

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 17, 1999, Pages 2537-2538

  Blanchard, Jill L ^a   Epstein, David M ^a   Boisclair, Michael D ^a   Rudolph, Johannes ^a   Pal, Kollol ^a  

^a GPC Biotech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTENOLIDE; CDC25; DYSIDIOLIDE; GAMMA HYDROXYBUTENOLIDE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY;

4-BUTYROLACTONE; CDC25 PHOSPHATASE; ENZYME INHIBITORS;

EID: 0033530145     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00431-X     Document Type: Article

References (9)

1. Dunphy, W. G.; Kumagai, A. Cell 1991, 67, 189.
2. Galaktionov, K.; Lee, A. K.; Eckstein, J.; Draetta, G.; Meckler, J.; Loda, M.; Beach, D. Science 1995, 269, 1575.
3. Cebula, R. C.; Blanchard, J. L.; Boisclair, M. D.; Pal, K.; Bockovich, N. J. Bioorg. Med. Chem. Lett. 1997, 7, 2015.
4. Gunasekera, S. P.; McCarthy, P. J.; Kelly-Borges, M.; Lobkovsky, E.; Clardy J. J. Am. Chem. Soc. 1996, 118, 8759.
5. (a) Corey, E. J.; Roberts, B. E. J. Am. Chem. Soc. 1997, 119, 12425.
6. (b) Magnuson, S. R.; Sepp-Lorenzino, L.; Rosen, N.; Danishefsky, S. J. J. Am. Chem. Soc. 1998, 120, 1615.
7. (c) Boukouvalas, J.; Cheng, Y.-X.; Robichaud, J. J. Org. Chem. 1998, 63, 228.
8. Gottlin, E. B.; Epstein, D. M.; Xu, X.; Burke, S. P.; Eckstein, J. W.; Ballou D. P.; Dixon, J. E. J. Biol. Chem. 1996, 271, 27445.
9. Xu, X.; Burke, S. P. J. Biol. Chem. 1996, 271, 5118.