IL-12/IL-12R system in multiple sclerosis

Journal of Neuroimmunology

Volumn 114, Issue 1-2, 2001, Pages 242-252

  Özenci, Volkan ^a   Pashenkov, Mikhail ^a   Kouwenhoven, Mathilde ^a   Rinaldi, Luciano ^a   Söderström, Mats ^a   Link, Hans ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

IL 12; IL 12 receptor; Multiple sclerosis; Th1 cells; Th2 cells

Indexed keywords

INTERLEUKIN 12 RECEPTOR;

ANTIGEN PRESENTING CELL; ARTICLE; CELL MEDIATED CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; MITOGENICITY; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; NATURAL KILLER CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PHYTOHEMAGGLUTININS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; TH1 CELLS; TH2 CELLS;

EID: 0035282832     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00449-5     Document Type: Article

References (28)

1. Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
2. IL-12 in Autoimmunity
3. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy
4. Reverse ELISPOT assay for clinical analysis of cytokine production. I. Enumeration of gamma-interferon secreting cells
5. IL-12 receptor. II. Distribution and regulation of receptor expression
6. Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis
7. Increased release of interleukin-12 p40 in MS: Association with intracerebral inflammation
8. The interleukin-12/Interleukin-12-receptor system: Role in normal and pathologic immune responses
9. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
10. Interleukin-12 is detectable in sera of patients with multiple sclerosis - Association with chronic progressive disease course?
11. Interferon beta in multiple sclerosis: Is IL-12 suppression the key?
12. Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity
13. Rating neurological impairment in multiple sclerosis: An expanded disability status scale (EDSS)
14. Interleukin-12 and perforin mRNA expression is augmented in blood mononuclear cells in multiple sclerosis
15. Type I IFNs inhibit human dendritic cell IL-12 production and Th1 development
16. IFN-beta differentially regulates CD-40-induced cytokine secretion by human dendritic cells
17. Cytokines and the pathogenesis of MS
18. Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system
19. Influence of infection on exacerbations of multiple sclerosis
20. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
21. A fuctional interleukin 12 receptor complex is composed of two beta-type receptor subunits
22. Selective expression of an interleukin-12 receptor component by human T helper 1 cells
23. Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo
24. Interleukin-12
25. Decreased interleukin-10 and increased interleukin-12 p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis
26. IFN-beta-1b inhibits IL-12 production in peripheral blood mononuclear cells in an IL-10-dependent mechanism: Relevance to IFN-beta-1b therapeutic effects in multiple sclerosis
27. Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is essential component of the functional mouse IL-12 receptor
28. IL-12 ELISPOT assays to detect and enumerate IL-12 secreting cells