Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate

Biochemical Journal

Volumn 354, Issue 2, 2001, Pages 397-406

  Liu, S X ^a   Kawai, K ^a   Tyurin, V A ^a   Tyurina, Y Y ^a   Borisenko, G G ^a   Fabisiak, J P ^a   Quinn, P J ^a   Pitt, B R ^a   Kagan, V E ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Copper; Phosphatidylserine; Phospholipid peroxidation; Redox cycling; S nitroso N acetyl penicillamine

Indexed keywords

COPPER DERIVATIVE; CYTOCHROME C; METALLOTHIONEIN; NITRIC OXIDE; NITRILOTRIACETIC ACID;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ENZYME RELEASE; HUMAN; HUMAN CELL; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANNEXIN A5; APOPTOSIS; CARCINOGENS; CASPASE 3; CASPASES; CHLORIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME C GROUP; DNA FRAGMENTATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; LIPID PEROXIDATION; METALLOTHIONEIN; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRILOTRIACETIC ACID; ORGANOMETALLIC COMPOUNDS; OXIDANTS; OXIDATION-REDUCTION; PENICILLAMINE; PHOSPHOLIPIDS; ZINC COMPOUNDS;

EID: 0035282221     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3540397     Document Type: Article

References (49)

1. Role of free radicals and catalytic metal ions in human disease: An overview
2. Cupric nitrilotriacetate induces oxidative DNA damage and apoptosis in human leukemia HL-60 cells
3. Free copper ions in the cell?
4. Ceruloplasmin: Physiological and pathological perspectives
5. Albumin - An important extracellular antioxidant?
6. Metal ion chaperone function of the soluble Cu(I) receptor Atx1
7. COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase
8. The copper chaperone for superoxide dismutase
9. The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drug
10. Redox regulation of copper-metallothionein
11. Evidence that nitric oxide enhances cadmium toxicity by displacing the metal from metallothionein
12. Control of zinc transfer between thionein, metallothionein, and zinc proteins
13. The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase
14. Thiolate ligands in metallothionein confer redox activity on zinc clusters
15. Antioxidant and anti-apoptotic function of metallothioneins in HL-60 cells challenged with copper-nitrilotriacetate
16. Bifunctional anti-/prooxidant potential of metallothionein: Redox signaling of copper binding and release
17. Reconstitution of apo-superoxide dismutase by nitric oxide-induced copper transfer from metallothionein
18. Induction of renal cell carcinoma in male Wistar rats treated with cupric nitrilotriacetate
19. Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis
20. Random versus selective membrane oxidation in apoptosis: Role of phosphatidylserine
21. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
22. 2+ induces metallothionein protein accumulation but not metallothionein isoform 2 mRNA
23. Detection and imaging of nitric oxide with novel fluorescent indicators: Diaminofluoresceins
24. Convenient colorimetric and fluorometric assays for S-nitrosothiols
25. Characterization of calf liver Cu,Zn-metallothionein: Naturally variable Cu and Zn stoichiometries
26. Sensitive and specific fluorescent probing of oxidative stress in different classes of membrane phospholipids in live cells using metabolically integrated cis-parinaric acid
27. A simple method for the isolation and purification of total lipids from animal tissues
28. Determination of lipid phosphorous in nanomolar range
29. Cytochrome c: Can't live with it - Can't live without it
30. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
31. Caspases and caspase inhibitors
32. Inhibition of cathepsin K by nitric oxide donors: Evidence for the formation of mixed disulfides and a sulfenic acid
33. Effect of S-nitrosothiols on cellular glutathione and reactive protein sulfhydryls
34. Distinct metal-binding configurations metallothionein
35. 2+
36. Stoichiometry and cluster specificity of copper binding to metallothionein: Homogeneous metal clusters
37. 2+ release from metallothionein by destroying zinic-sulphur clusters without concomitant formation of S-nitrosothiol
38. Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein
39. Mechanism of S-nitrosothiol formation and degradation mediated by copper ions
40. Copper chelation-induced reduction of the biological activity of S-nitrosothiols
41. Steric effect and effect of metal coordination on the reactivity of nitric oxide with cysteine-containing proteins under anaerobic conditions
42. 2 with sulfhydryl groups in HL-60 cells: Zn-metallothionein and other sites
43. Thioredoxin regenerates proteins inactivated by oxidative stress in endothelial cells
44. Thioltransferase is a specific glutathionyl mixed disulfide oxidoreductase
45. Energy-dependent nuclear binding dictates metallothionein localization
46. Nuclear localization of metallothionein during cell proliferation and differentiation
47. Nitric oxide dissociates lipid oxidation from apoptosis and phosphatidylserine externalization during oxidative stress
48. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1 beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases
49. The elusive function of metallothioneins