Antioxidant and antiapoptotic function of metallothioneins in HL-60 cells challenged with copper nitrilotriacetate

Chemical Research in Toxicology

Volumn 13, Issue 12, 2000, Pages 1275-1286

  Kawai, Kazuaki ^a   Liu, Shang Xi ^a   Tyurin, Vladimir A ^a   Tyurina, Yulia Y ^a   Borisenko, Grigory G ^a   Jiang, Jian Fei ^a   St Croix, Claudette M ^a,b   Fabisiak, James P ^a   Pitt, Bruce R ^a,b   Kagan, Valerian E ^a,b,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CHELATING AGENT; COPPER DERIVATIVE; METALLOTHIONEIN; NITRILOTRIACETIC ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL STRAIN HL 60; CHELATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTOXICATION; KNOCKOUT MOUSE; LUNG FIBROBLAST; OXIDATIVE STRESS; PROTEIN SECRETION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CAMPTOTHECIN; CASPASE 3; CASPASES; CELL NUCLEUS; CHLORIDES; FIBROBLASTS; HL-60 CELLS; HUMANS; LIPID PEROXIDATION; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRILOTRIACETIC ACID; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; ZINC COMPOUNDS;

EID: 17744387704     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000119l     Document Type: Article

References (2)

1. Hamer, D. H. (1986) Metallothionein. Annu. Rev. Biochem. 55, 913-951.
2. Klassen, C. D., Liu, J., and Choudhuri, S. (1999) Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol. 39, 267-294.