Induction of renal cell carcinoma in male Wistar rats treated with cupric nitrilotriacetate

Laboratory Investigation

Volumn 75, Issue 2, 1996, Pages 239-248

  Toyokuni, Shinya ^a   Tanaka, Tomoyuki ^a   Nishiyama, Yasuyuki ^a,b   Okamoto, Keisei ^a   Nakashima, Yasuaki ^a,b   Hamazaki, Shuji ^c   Okada, Shigeru ^d   Hiai, Hiroshi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c OKAYAMA UNIVERSITY HOSPITAL   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; NITRILOTRIACETATE COPPER; NITRILOTRIACETATE IRON; NITRILOTRIACETIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; COPPER METABOLISM; HEMOSIDEROSIS; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY CARCINOMA; LIVER FAILURE; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARCINOMA, RENAL CELL; COPPER; KIDNEY NEOPLASMS; MALE; NITRILOTRIACETIC ACID; ORGANOMETALLIC COMPOUNDS; RATS; RATS, WISTAR;

EID: 0029784201     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Anderson RL, Bishop WE, and Campbell RL (1985). A review of the environmental and mammalian toxicology of nitrilotriacetic acid. Crit Rev Toxicol 15:1-102.
2. Aruoma OI, Halliwell B, Gajewski E, and Dizdaroglu M (1991). Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem J 273:601-604.
3. Aruoma OI, Halliwell B, Gajewski E, and Dizdaroglu M (1989). Damage to the bases in DNA induced by hydrogen peroxide and ferric ion chelates. J Biol Chem 264:20509-20512.
4. Awai M, Narasaki M, Yamanoi Y, and Seno S (1979). Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate: A model of experimental hemochromatosis. Am J Pathol 95:663-674.
5. Chiou S-H (1984). DNA-scission activities of ascorbate in the presence of metal chelates. J Biochem (Tokyo) 96:1307-1310.
6. Dizdaroglu M, Rao G, Halliwell B, and Gajewski E (1991). Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions. Arch Biochem Biophys 285:317-324.
7. Ebina Y, Okada S, Hamazaki S, and Midorikawa O (1984). Liver, kidney and central nervous system toxicity of aluminum given intraperitoneally to rats: A multiple dose subchronic study using aluminum nitrilotriacetate. Toxicol Appl Pharmacol 75:211-218.
8. Ebina Y, Okada S, Hamazaki S, Ogino F, Li J-L, and Midorikawa O (1986). Nephrotoxicity and renal cell carcinoma after use of iron- and aluminum-nitriotriacetate complexes in rats. J Natl Cancer Inst 76:107-113.
9. Ebina Y, Okada S, Hamazaki S, Toda Y, and Midorikawa O (1991). Impairment of bone formation with aluminum and ferric nitrilotriacetate complexes. Calcif Tissue Int 48:28-36.
10. Everiff JI, Goldsworthy TL, Wolf DC, and Walker CL (1992). Hereditary renal cell carcinoma in Eker rat: A rodent familial cancer syndrome. J Urol 148:1932-1936.
11. Floyd RA (1990). The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis 11:1447-1450.
12. Gettleman L, Cocks FH, Darmiento LA, Levine PA, Wright S, and Nathanson D (1980). Measurement of in vivo corrosion rates in baboons and correlation with in vitro tests. J Dent Res 59:689-707.
13. Goh TH and Tong SL (1986). A comparison of the Multiload Cu250, TCu 220C and Cu7 IUDs. Contraception 33:411-420.
14. Halliwell B and Aruoma OI (1993). DNA and free radicals. Chichester, England: Ellis Horwood Ltd.
15. Halliwell B and Gutteridge JMC (1989). Free radicals in biology and medicine, 2nd ed. Oxford: Clarendon Press, 33-46.
16. Hamazaki S, Okada S, Ebina Y, Fujioka M, and Midorikawa O (1986). Nephrotoxicity of ferric nitrilotriacetate: An electron-microscopic and metabolic study. Am J Pathol 123:343-350.
17. Hamazaki S, Okada S, Ebina Y, and Midorikawa O (1985). Acute renal failure and glucosuria induced by ferric nitrilotriacetate in rats. Toxicol Appl Pharmacol 77:267-274.
18. Izumi K, Kitaura K, Chone Y, Täte H, Nakagawa T, Suzuki Y, and Matsumoto K (1994). Spontaneous renal cell tumors in Long-Evans Cinnamon rats. Jpn J Cancer Res 85:563-566.
19. Kato J, Kohgo Y, Sugawara N, Katsuki S, Shintani N, Fujikawa K, Miyazaki E, Kobune M, Takeichi N, and Niitsu Y (1993). Abnormal hepatic iron accumulation in LEC rats. Jpn J Cancer Res 84:219-222.
20. Kawahara H (1983). Cellular responses to implant materials: Biological, physiological and chemical factors. Int Dent J 4:350-375.
21. Kazakov SA, Astashkina TG, Mamaev SV, and Vlasov W (1988). Site-specific cleavage of single-stranded DNAs at unique sites by a copper-dependent redox reaction. Nature 335:186-188.
22. Kobayashi T, Hirayama Y, Kobayashi E, Kubo Y, and Hino O (1995). A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat Genet 9:70-74.
23. Li J-L, Okada S, Hamazaki S, Ebina Y, and Midorikawa O (1987). Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res 47:1867-1869.
24. Maekawa A, Onodera H, Tanigawa H, Furuta K, Kodama Y, Horiuchi S, and Hayashi Y (1983). Neoplastic and non-neoplastic lesions in aging Slc:Wistar rats. J Toxicol Sci 8:279-290.
25. Moo-Young AJ, Tatum HJ, Wan LS, and Lane M (1975). Copper levels in tissues of rhesus monkeys and of women bearing intrauterine copper devices. In: Hafnawi F and Segal J, editors. Analysis of intrauterine contraception. New York: Elsevier, 439-457.
26. Mori M, Hattori A, Sawaki M, Tsuzuki N, Sawada N, Oyamada M, Sugawara N, and Enomoto A (1994). The LEC rat: A model for human hepatitis, liver cancer, and much more. Am J Pathol 144:200-204.
27. Mostofi FK (1981). Histological typing of kidney tumors. In: Mostofi FK, editor. International histological classification of tumors, no. 25. Geneva: World Health Organization.
28. Mottola HA (1974). Nitrilotriacetic acid as a chelating agent: Applications, toxicology, and bio-environmental impact. Toxicol Environ Chem Rev 71:99-161.
29. Newton J and Tacchi D (1990). Long-term use of copper intrauterine devices. Lancet 335:1332-1333.
30. Nishiyama Y, Suwa H, Okamoto K, Fukumoto M, Hiai H, and Toyokuni S (1995). Low incidence of point mutations in H-, K- and N-ras oncogenes and p53 tumor suppressor gene in renal cell carcinoma and peritoneal mesothelioma of Wistar rats induced by ferric nitrilotriacetate. Jpn J Cancer Res 86:1150-1158.
31. Okada S, Hamazaki S, Ebina Y, Li J-L, and Midorikawa O (1987). Nephrotoxicity and its prevention by vitamin E on ferric nitrilotriacetate-promoted lipid peroxidation. Biochim Biophys Acta 922:28-33.
32. Okada S and Midorikawa O (1982). Induction of rat renal adenocarcinoma by Fe-nitrilotriacetate (Fe-NTA). Jpn Arch Intern Med 29:485-491.
33. Ozaki M, Kawabata T, and Awai M (1988). Iron release from haemosiderin and production of iron-catalyzed hydroxyl radicals in vitro. Biochem J 250:589-595.
34. Reid TM and Loeb LA (1993). Tandem double CC to TT mutations are produced by reactive oxygen species. Proc Natl Acad Sci USA 90:3904-3907.
35. Sagripanti J-L and Kraemer KH (1989). Site-specific oxidative DNA damage at polyguanosines produced by copper plus hydrogen peroxide. J Biol Chem 264:1729-1734.
36. Sternlieb I (1987). Hepatic lysosomal copper-thionein. In: Kaegi JHR and Kojima Y, editors. Metallothionein II: Experimentia supplementum, vol 52. Basel: Birkhaeuser Verlag, 647-653.
37. Stevens RG, Jones DY, Micozzi MS, and Taylor PR (1988). Body iron stores and the risk of cancer. N Engl J Med 319:1047-1052.
38. Sugawara N, Sugawara C, Katakura M, Takahashi H, and Mori M (1991). Copper metabolism in the LEC rat: Involvement of induction of metallothionein and deposition of zinc and iron. Experimentia 47:1060-1063.
39. Sunderman FW Jr (1978). Carcinogenic effects of metals. Fed Proc 37:40-46.
40. Sunderman FW Jr, Maenza RM, Hopfer SM, Mitchell JM, Allpass PR, and Damjanov I (1979). Induction of renal cancers in rats by intrarenal injection of nickel subsulfide. J Environ Pathol Toxicol 2:1511-1527.
41. Tkeshelashvili LK, McBride T, Spence K, and Loeb LA (1991). Mutation spectrum of copper-induced DNA damage. J Biol Chem 266:6401-6406.
42. Toyokuni S (1996). Iron-induced carcinogenesis: The role of redox regulation. Free Radic Biol Med 20:553-566.
43. Toyokuni S, Mori T, and Dizdaroglu M (1994). DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int J Cancer 57:123-128.
44. Toyokuni S, Mori T, Hiai H, and Dizdaroglu M (1995). Treatment of Wistar rats with a renal carcinogen, ferric nitrilotriacetate, causes DNA-protein cross-linking between thymine and tyrosine in their renal chromatin. Int J Cancer 62:309-313.
45. Toyokuni S, Okada S, Hamazaki S, Fujioka M, Li J-L, and Midorikawa O (1989). Cirrhosis of the liver induced by cupric nitrilotriacetate in Wistar rats: An experimetnal model of copper toxicosis. Am J Pathol 134:1263-1274.
46. Toyokuni S, Okada S, Hamazaki S, Minamiyama Y, Yamada Y, Liang P, Fukunaga Y, and Midorikawa O (1990). Combined histochemical and biochemical analysis of sex hormone dependence of ferric nitrilotriacetate-induced renal lipid peroxidation in ddY mice. Cancer Res 50:5574-5580.
47. Toyokuni S and Sagripanti J-L (1993). DNA single- and double-strand breaks produced by ferric nitrilotriacetate in relation to renal tubular carcinogenesis. Carcinogenesis 14: 223-227.
48. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H, and Stadtman ER (1994). Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci USA 91:2616-2620.
49. Tsong YY and Nash HA (1991). Effect of tarnish on copper release. Contraception 44:385-391.
50. Waalkes MP (1995). Metal carcinogenesis. In: Goyer RA, Klaassen CD, and Waalkes MP, editors. Metal toxicology. San Diego: Academic Press, 47-69.
51. Webbs M (1982). Role of metallothioneins and other binding proteins in the renal handling and toxicity of metals. In: Bach PH, Bonner FW, Bridges JW, and Lock EA, editors. Nephrology: Assessment and pathogenesis. Chichester, England: John Wiley & Sons, 296-309.
52. Wu J, Forbes JR, Chen HC, and Cox DW (1994). The LEC rat has a deletion in the copper tranporting ATPase gene homologous to the Wilson disease gene. Nat Genet 7:541-545.
53. Yamamoto K and Kawanishi S (1989). Hydroxyl free radical is not the main active species in site- specific DNA damage induced by copper(II) ion and hydrogen peroxide. J Biol Chem 264:15435-15440.