Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma

Journal of Immunology

Volumn 166, Issue 3, 2001, Pages 1991-2001

  Ishimitsu, R ^a   Nishimura, H ^a   Yajima, T ^a   Watase, T ^a   Kawauchi, H ^a   Yoshikai, Y ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; INTERLEUKIN 15; MONOCLONAL ANTIBODY;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHILIA; GENE OVEREXPRESSION; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0035253738     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.3.1991     Document Type: Article

References (58)

1. Inflammatory mediators of asthma: An update
2. Mast-cell-leukocyte cytokine cascades in allergic inflammation
3. Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness: A murine model
4. The role of allergy in the development of asthma
5. Antiproliferative effect of IFN-γ in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-γ
6. Natural killer cell stimulatory factor (interleukin 12 (IL-12)) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
7. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
8. The interleukin (IL) 2 receptor β-chain, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells
9. Cloning of a T cell growth factor that interacts with the β-chain of the interleukin-2 receptor
10. IL-15: A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels
11. Interleukin-2, interleukin-15, and their receptors
12. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
13. A potential role of interleukin-15 in the regulation of human natural killer cell survival
14. Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells
15. IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation
16. + T cells in the absence of TCR ligation
17. IL-15 promotes cytokine production of human T helper cells
18. The role of interleukin 15 in T-cell migration and activation in rheumatoid arthritis
19. Interleukin- 15 mediates T cell-dependent regulation of tumor necrosis factor production in rheumatoid arthritis
20. Increased numbers of interleukin-15-expressing cells in active ulcerative colitis
21. Interleukin 15 activity in the rectal mucosa of inflammatory bowel disease
22. Differential roles of interleukin-15 mRNA isoforms generated by alternative splicing in immune responses in vivo
23. Chromosomal assignment and genomic structure of IL-15
24. + T cell clones mediate the in vivo inhibition of rat IgE
25. + T cells in vivo by IL-15
26. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
27. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
28. + memory T cells by opposing cytokines
29. Presentation of exogenous antigen with class I major histocompatibility complex molecules
30. Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo
31. + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production
32. Mechanism of MHC-class I-restricted antigen processing
33. Alternative pathways for processing exogenous and endogenous antigens that can generate peptides for MHC class I-restricted presentation
34. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones
35. Requirement for IRF-1 in the microenviroment supporting development of natural killer cells
36. Induction of differentiation of pre-NKT cells to mature Vα14 NKT cells by granulocyte/macrophage colony-stimulating factor
37. + T) cells, natural killer cells, and intestinal intraepithelial T cells
38. IL-15 is a novel growth factor for murine γ-δ T cells induced by Salmonella infection
39. Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice
40. IL-15 enhances the response of human γδ T cells to non-peptide microbial antigens
41. + intestinal intraepithelial lymphocytes
42. -1- mice: Roles for both IL-2 and IL-15 in CD8αα IEL development
43. Requirement for γδ T cells in allergic airway inflammation
44. Nebulized but not parental IFN-γ decreases IgE production and normalizes airways functions in a murine model of allergen sensitization
45. Differential effects of endogenous and exogenous interferon-γ on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma
46. Nebulized IFN-γ inhibits the development of secondary allergic responses in mice
47. The effects of nebulized recombinant interferon-γ in asthmatic airways
48. The kinetics of change in cytokine production by CD4 T cells during conventional allergen immunotherapy
49. Allergen-induced recruitment of bronchoalveolar helper (OKT4) and (OKT8) T-cells in asthma; relative increases in OKT8 cells in single early responders compared with those in late-phase responders
50. + T-cell depletion on bronchial hyper-responsiveness and inflammation in sensitized and allergen-exposed Brown-Norway rats
51. Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells
52. +) T lymphocytes
53. Decreased production of IFN γ and increased production of IL-6 by cord blood mononuclear cells of newborns with a high risk of allergy
54. Serum levels of interleukin-4, soluble CD23 and IFN γ in relation to the development of allergic disease during the first 18 months of life
55. Reduced interferon-γ secretion in neonates and subsequent atopy
56. Multiple sclerosis with mite antigen-specific IgE
57. Decreased prevalence of atopy in rheumatoid arthritis
58. Early BCG vaccination and development of atopy