Interleukin-15 differentially enhances the expression of interferon-γ and interleukin-4 in activated human (CD4+) T lymphocytes

Immunology

Volumn 96, Issue 2, 1999, Pages 207-214

  Borger, P ^b   Kauffman, H F ^b   Postma, D S ^b   Esselink, M T ^b   Vellenga, E ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CONCANAVALIN A; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 7; MESSENGER RNA;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; FLUORESCENCE ACTIVATED CELL SORTER; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANTIBODIES; ANTIGENS, CD28; ANTIGENS, CD3; BLOTTING, NORTHERN; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CONCANAVALIN A; FLOW CYTOMETRY; HUMANS; INTERFERON TYPE II; INTERLEUKIN-15; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032896540     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00679.x     Document Type: Article

References (29)

1. 1. GRABSTEIN K.H., EISENMAN J., SHANEBECK K. et al. (1984) Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264, 965.
2. 2. DOHERTY T.M., SEDER R.A. & SHER A. (1996) Induction and regulation of IL-15 expression in murine macrophages. J Immuno 156, 735.
3. 3. CARSON W.E., GIRI J.G., LINDEMANN M.J. et al. (1994) Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180, 1395.
4. 4. WILKINSON P.C. & LIEW F.Y. (1995) Chemoattraction of blood T lymphocytes by interleukin-15. J Exp Med 181, 1255.
5. 5. MORI A., SUKO M., KAMINUMA O. et al. (1996) IL-15 promotes cytokine production of human T helper cells. J Immunol 156, 2400.
6. 6. GIRI J.G., ADHIE M., EISENMANN J. et al. (1994) Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13, 2822.
7. 7. TOUW I., POUWELS K., VAN AGTHOVEN T. et al. (1990) Interleukin-7 is a growth-factor of precursor B and T acute lymphoblastic leukemia. Blood 75, 2097.
8. 8. HICKMAN C.J., CRIM J.A., MOSTOWSKI H.S. & SIEGEL J.P. (1990) Regulation of human cytotoxic T lymphocyte development by IL-7. J Immunol 145, 2415.
9. 9. ALDERSON M.R., SASSENFELD H.M. & WIDMER M.B. (1990) Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood. J Exp Med 172, 577.
10. 10. GRABSTEIN K.H., NAMEN A.E., SHANEBECK K., VOICE R.F., REED S.G. & WIDMER M.B. (1990) Regulation of T cell proliferation by IL-7. J Immunol 144, 3015.
11. 11. ARMITAGE R.J., NAMEN A.E., SASSENFELD H.M. & GRABSTEIN K.H. (1990) Regulation of human T cell proliferation by IL-7. J Immunol 144, 938.
12. 12. DOKTER W.H.A., SIERDSEMA S.J., ESSELINK M.T., HALIE M.R. & VELLENGA E. (1993) IL-7 enhances the expression of IL-3 and granulocyte macrophage CSF mRNA in activated human T cells by post-transcriptional mechanisms. J Immunol 150, 2584.
13. 13. DOKTER W.H.A., SIERDSEMA S.J., ESSELINK M.T., HALIE M.R. & VELLENGA E. (1994) Interleukin-4 mRNA and protein in activated human T cells are enhanced by IL-7. Exp Hematol 22, 74.
14. 14. BORGER P., KAUFFMAN H.F., POSTMA D.S. & VELLENGA E. (1996) IL-7 differentially modulates the expression of IFN-γ and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms. J Immunol 156, 1333.
15. 15. DE GRINGHUIS S.I.L.F., LEIJ E.W., VERSCHUREN P., BORGER & VELLENGA E. (1997) Interleukin (IL) -7 upregulates the IL-2 gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein 1. Blood 90, 2690.
16. 16. LIN J.X., MIGONE T.S., TSANG M. et al. (1995) The role of shared receptor motifs and common Stat proteins in the generations of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity 2, 331.
17. c chain of the IL-2 receptor. Science 266, 1039.
18. 18. BORGER P., KAUFFMAN H.F., POSTMA D.S. & VELLENGA E. (1996) Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway. Blood 87, 691.
19. 19. VELLENGA E., RAMBALDI A., ERNST T.J., OSTAPOVICZ D. & GRIFFIN J.D. (1988) Independent regulation of M-CSF and G-CSF gene expression in human monocytes. Blood 71, 1529.
20. 20. CHOMCZYNSKI P. & SACCHI N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Anal Biochem 162, 156.
21. 21. MANIATIS T., FRITSCH E.F. & SAMBROOK A. (1982) Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring, Harbor, NY.
22. 22. FEINBERG A.P. & VOGELSTEIN B. (1983) A technique for labeling DNA restriction endonuclease fragments with high specific activity. Anal Biochem 132, 6.
23. 23. NISHIMURA H., HEROMATSU K., KABAYASHI N. et al. (1996) IL-15 is a novel growth factor for murine γδ T cells induced by Salmonella infection. J Immunol 156, 663.
24. 24. ZIEGLER S.F., MORELLA K.K., ANDERSON D. et al. (1995) Reconstitution of a functional interleukin (IL) -7 receptor demonstrates that the IL-2 receptor γ chain is required for IL-7 signal transduction. Eur J Immunol 25, 399.
25. 25. CHELEN C.J., FANG Y., FREEMAN G.J. et al. (1994) Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules. J Clin Invest 95, 1415.
26. 26. HOLTON R.H. & BOST K.L. (1996) Interleukin 15 (IL-15) is upregulated in mucosal tissues, following oral inoculation with Salmonella: a possible role for IL-15 in the immune response against this pathogen. FASEB J 10, A1167.
27. 27. CORRIGAN C.J. & KAY A.B. (1992) T cells and cosinophils in the pathogenesis of asthma. Immunol Today 13, 501.
28. 28. BENJAMIN D., SHARMA V., KNOBLOCH T.J., ARMITAGE R.J., DAYTON M.A. & GOODWIN R.G. (1994) B-cell IL-7. human B-cell lines constitutively secrete IL-7 and express IL-7 receptors. J Immunol 152, 4749.
29. 29. DE GRINGHUIS S.I., DE LEU L.F.M.H. & VELLENGA E. (1998) Serine phosphorylation of STAT 5 in response to interleukin-7 and T cell receptor activation is mediated by the mitogen-activated protein kinase p38/Mpk2 in human T lymphocytes, (submitted).