Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins

Nucleic Acids Research

Volumn 29, Issue 3, 2001, Pages 732-742

  Quinn, Zoë A ^a,b   Yang, Chih Chin ^a   Wrana, Jeffrey L ^c   McDermott, John C ^a,b  

^a YORK UNIVERSITY   (Canada)

^b DURHAM UNIVERSITY   (United Kingdom)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; GALACTOSE; GLUTATHIONE TRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MYOCYTE ENHANCER FACTOR 2; REGULATOR PROTEIN; SMAD PROTEIN; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME MECHANISM; GENE CONTROL; GENE MUTATION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VIVO STUDY; MOUSE; MUSCLE FIBRIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0035253631     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.3.732     Document Type: Article

References (93)

1. Controlling TGF-beta signaling
2. BMPs: Actions in flesh and bone
3. Regulation of Smad signalling by protein associations and signalling crosstalk
4. Signal transduction. An anchor for activation [news]
5. Regulation of Smad activity
6. Signalling to the nucleus by members of the transforming growth factor-beta (TGF-beta) superfamily
7. TGF-beta Signaling: Receptors, Transducers and Mad Proteins
8. Genetic and Biochemical Analysis of TGF-beta Signal Transduction
9. The TGF-beta superfamily: New members, new receptors and new genetic test of function in different organisms
10. TGF beta signals through a heteromeric protein kinase receptor complex
11. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors
12. Determination of type I receptor specificity by the type II receptors for TGF-beta or activin
13. Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor
14. GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex
15. Mechanism of activation of the TGF-beta receptor
16. The smad pathway [In Process Citation]
17. Transcriptional control by the TGF-beta/Smad signaling system
18. Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila
19. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
20. A human Mad protein acting as a BMP-regulated transcriptional activator [see comments]
21. Caenorhabditis elegans genes sma-2, sma-3 and sma-4 define a conserved family of transforming growth factor beta pathway components
22. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
23. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function
24. TGF-beta signalling from cell membrane to nucleus through SMAD proteins
25. Mads and Smads in TGF beta signalling
26. SMADs: Mediators and regulators of TGF-beta signaling
27. MADR1, a MAD-related protein that functions in BMP2 signaling pathways
28. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin
29. Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
30. MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
31. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
32. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
33. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling
34. Crystal structure of a transcriptionally active Smad4 fragment
35. Interaction of Smad complexes with tripartite DNA-binding sites
36. A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3
37. Molecular mechanisms of Spemann's organizer formation: Conserved growth factor synergy between Xenopus and mouse
38. Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
39. Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif
40. Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins
41. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
42. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
43. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
44. Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3
45. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors
46. c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads
47. TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein
48. Role of p300, a transcriptional coactivator, in signalling of TGF-beta
49. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300
50. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
51. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
52. Transcriptional regulation of the TGF-β-inducible mouse germ-line Ig α constant region gene by functional cooperation of Smad, CREB and AML family members
53. Determinants of specificity in TGF-beta signal transduction
54. A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter
55. MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex
56. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors
57. A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage
58. Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2
59. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins
60. Muscle minus myoD
61. An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression
62. Myocyte-specific enhancer factor 2 and thyroid hormone receptor associate and synergistically activate the alpha-cardiac myosin heavy-chain gene
63. A single MEF2 site governs desmin transcription in both heart and skeletal muscle during mouse embryogenesis
64. The RSRF/MEF2 protein SLI regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos
65. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand
66. The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin I and VEGF
67. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
68. Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation
69. Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis
70. Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes
71. The MADS domain containing transcription factor cMef2a is expressed in heart and skeletal muscle during embryonic chick development
72. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2
73. Regulation of the MEF2 family of transcription factors by p38
74. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
75. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1
76. Post-translational control of the MEF2A transcriptional regulatory protein
77. A dominant-negative form of transcription factor MEF2 inhibits myogenesis
78. MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells
79. Activation of signalling by the activin receptor complex
80. Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region
81. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
82. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors
83. TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
84. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
85. Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts
86. Inhibition of myogenesis by transforming growth factor beta is density-dependent and related to the translocation of transcription factor MEF2 to the cytoplasm
87. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
88. Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
89. A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila
90. Drosophila MEF2, a transcription factor that is essential for myogenesis
91. D-mef2 is a target for Tinman activation during Drosophila heart development
92. Combinatorial control of Drosophila mef2 gene expression in cardiac and somatic muscle cell lineages
93. Transcription of the myogenic regulatory gene Mef2 in cardiac, somatic and visceral muscle cell lineages is regulated by a Tinman-dependent core enhancer