Characterisation of the transition states for protein folding: Towards a new level of mechanistic detail in protein engineering analysis

Current Opinion in Structural Biology

Volumn 11, Issue 1, 2001, Pages 94-100

  Oliveberg, M ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN S6; PROTEIN U1A; UNCLASSIFIED DRUG;

COMPARATIVE STUDY; GENETIC ENGINEERING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS;

EID: 0035252685     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00171-8     Document Type: Article

References (50)

1. Protein folding intermediates and pathways studied by hydrogen exchange
2. Finding the right fold
3. A surprising simplicity to protein folding
4. From snapshot to movie: Phi analysis of protein folding transition states taken one step further
5. How do small single-domain proteins fold?
6. Mapping the transition state and pathway of protein folding by protein engineering
7. Structure of the hydrophobic core in the transition state for folding of chymotrypsin inhibitor 2: A critical test of the protein engineering method of analysis
8. Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and it simplifications for mechanisms of protein folding
9. Protein folding dynamics: Quantitative comparison between theory and experiment
10. The formation of a native-like structure containing eight conserved hydrophobic residues is rate limiting in two-state protein folding of ACBP
11. The folding of an immunoglobulin-like Greek key protein is defined by a common-core nucleus and regions constrained by topology
12. Folding pathway of FKBP12 and characterisation of the transition state
13. Mapping the interactions present in the transition state for unfolding/folding of FKBP12
14. Structure of the transition state in the folding process of human procarboxypeptidase A2 activation domain
15. Stabilisation of alpha-helices by site-directed mutagenesis reveals the importance of secondary structure in the transition state for acylphosphatase folding
16. Two proteins with the same structure respond very differently to mutation: The role of plasticity in protein stability
17. Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking
18. Optimization of rates of protein folding: The nucleation-condensation mechanism and its implications
19. Identifying the protein folding nucleus using molecular dynamics
20. Single versus parallel pathways of protein folding and fractional formation of structure in the transition state
21. New approach to the study of transient protein conformations: The formation of a semiburied salt link in the folding pathway of barnase
22. The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved
23. Experiment and theory highlight role of native state topology in SH3 folding
24. Critical role of beta-hairpin formation in protein G folding
25. A breakdown of symmetry in the folding transition state of protein L
26. Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding
27. Beta-sheet proteins with nearly identical structures have different folding intermediates
28. Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9
29. Contact order, transition state placement and the refolding rates of single domain proteins
30. A simple model for calculating the kinetics of protein folding from three-dimensional structures
31. Matching theory and experiment in protein folding
32. A theoretical search for folding/unfolding nuclei in three-dimensional protein structures
33. Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures
34. Transition-state structure as a unifying basis in protein-folding mechanisms: Contact order, chain topology, stability, and the extended nucleus mechanism
35. Alternative explanations for multi-state kinetics in protein folding: Transient aggregation and changing transition-state ensembles
36. High-energy channeling in protein folding
37. Application of physical organic chemistry to engineered mutants of proteins - Hammond postulate behaviour in the transition state of protein folding
38. P22 arc repressor: Transition state properties inferred from mutational effects on the rates of protein unfolding and refolding
39. The changing nature of the protein folding transition state: Implications for the shape of the free-energy profile for folding
40. Structural changes in the transition state of protein folding: Alternative interpretations of curved chevron plots
41. Intermediates can accelerate protein folding
42. Denaturant-induced movement of the transition state of protein folding revealed by high-pressure stopped-flow measurements
43. Salt-induced detour through compact regions of the protein folding landscape
44. A polar, solvent-exposed residue can be essential for native protein structure
45. Similarities between the spectrin SH3 domain denatured state and its folding transition state
46. Thermodynamic analysis of aplpha-spectrin SH3 and two of its circular permutants with different loop lengths: Discerning the reasons for rapid folding in proteins
47. The nucleation-collapse mechanism in protein folding: Evidence for the non-uniqueness of the folding nucleus
48. Measurements of cysteine reactivity during protein unfolding suggest the presence of competing pathways
49. Statistical mechanics of a correlated energy landscape for protein folding funnels