Ageing and the immune system

Novartis Foundation Symposium

Volumn 235, Issue , 2001, Pages 130-145

  Effros, Rita B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

AGING; ANIMAL; APOPTOSIS; B LYMPHOCYTE; HEMATOPOIESIS; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; INNATE IMMUNITY; MACROPHAGE; MUCOSAL IMMUNITY; REVIEW; T LYMPHOCYTE; TELOMERE;

AGING; ANIMALS; APOPTOSIS; B-LYMPHOCYTES; HEMATOPOIESIS; HUMANS; IMMUNE SYSTEM; IMMUNITY, MUCOSAL; IMMUNITY, NATURAL; MACROPHAGES; T-LYMPHOCYTES; TELOMERASE; TELOMERE;

EID: 0035230140     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (35)

1. Aspinall R, Carroll J, Jiang S 1998 Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood. Exp Gerontol 33:581-591
2. Ben-Yehuda A, Wirtheim E, Abdulhai A et al 1999 Activation of the recombination activating gene 1 (RAG-1) transcript in bone marrow of senescent C57BL/6 mice by recombinant interleukin-7. J Gerontol A Biol Sci Med Sci 54:B143-B148
3. Bender BS, Ulmer JB, DeWitt CM et al 1998 Immunogenicity and efficacy of DNA vaccines encoding influenza A proteins in aged mice. Vaccine 16:1748-1755
4. Bodnar AG, Kim NW, Effros RB, Chiu CP 1996 Mechanism of telomerase induction during T cell activation. Exp Cell Res 228:58-64
5. Boucher N, Defeu-Duchesne T, Vicaut E, Farge D, Effros RB, Schchter F 1998 CD28 expression in T cell aging and human longevity. Exp Gerontol 33:267-282
6. Effros RB, Pawelec G 1997 Replicative senescence of T lymphocytes: does the Hayflick limit lead to immune exhaustion? Immunol Today 18:450-454
7. Effros RB, Allsopp R, Chiu CP et al 1996 Shortened telomeres in the expanded CD28-CD8+ subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10: F17-F22
8. Franceschi C, Monti D, Sansoni P, Cossarizza A 1995 The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 16:12-16
9. Garg M, Luo W, Kaplan AM, Bondada S 1996 Cellular basis of decreased immune responses to pneumococcal vaccines in aged mice. Infect Immun 64:4456-4462
10. Globerson A 1997 Thymocytopoiesis in aging: the bone marrow-thymus axis. Arch Gerontol Geriatr 24:141-155
11. Kline GH, Hayden TA, Klinman NR 1999 B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J Immunol 162:3342-3349
12. Ku CC, Kotzin B, Kappler J, Marrack P 1997 CD8+ T-cell clones in old mice. Immunol Rev 160:139-144
13. LeMaoult J, Szabo P, Weksler ME 1997 Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol Rev 160:115-126
14. Linton PJ, Haynes L, Klinman NR, Swain SL 1996 Antigen-independent changes in naive CD4 T cells with aging. J Exp Med 184:1891-1900
15. Maini MK, Casorati G, Dellabona P, Wack A, Beverley PC 1999 T-cell clonality in immune responses. Immunol Today 20:262-266
16. Mariani E, Ravaglia G, Meneghetti A et al 1998 Natural immunity and bone and muscle remodelling hormones in the elderly. Mech Ageing Dev 102:279-292
17. Miller C, Kelsoe G 1995 Ig VH hypermutation is absent in the germinal centers of aged mice. J Immunol 155:3377-3384
18. Monteiro J, Batliwalla F, Ostrer H, Gregersen PK 1996 Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J Immunol 156:3587-3590
19. Mosley RL, Koker MM, Miller RA 1998 Idiosyncratic alterations of TCR size distributions affecting both CD4 and CD8 T cell subsets in aging mice. Cell Immunol 189:10-18
20. Mountz JD, Wu J, Zhou T, Hsu HC 1997 Cell death and longevity: implications of Fas-mediated apoptosis in T-cell senescence. Immunol Rev 160:19-30
21. Nociari MM, Telford W, Russo C 1999 Postthymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype. J Immunol 162:3327-3335
22. Pahlavani MA, Harris MD, Richardson A 1997 The increase in the induction of IL-2 expression with caloric restriction is correlated to changes in the transcription factor NFAT. Cell Immunol 180:10-19
23. Pilling D, Akbar AN, Girdlestone J et al 1999 Interferon-beta mediates stromal cell rescue of T cells from apoptosis. Eur J Immunol 29:1041-1050
24. Ponnappan U, Zhong M, Trebilcock GU 1999 Decreased proteasome-mediated degradation in T cells from the elderly: a role in immune senescence. Cell Immunol 192:167-174
25. Remarque EJ 1999 Influenza vaccination in elderly people. Exp Gerontol 34:445-452
26. Rodewald HR 1998 The thymus in the age of retirement. Nature 396:630-631
27. Schenk D, Barbour R, Dunn W et al 1999 Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173-177
28. Schmucker DL, Heyworth MF, Owen RL, Daniels CK 1996 Impact of aging on gastrointestinal mucosal immunity. Dig Dis Sci 41:1183-1193
29. Solana R, Alonso MC, Peana J 1999 Natural killer cells in healthy aging. Exp Gerontol 34: 435-443
30. Spaulding C, Walford RL, Effros RB 1996 The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis. Mech Dev 93:25-33
31. Stephan RP, Lill-Elghanian DA, Witte PL 1997 Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J Immunol 158:1598-1609
32. Vaziri H, Schchter F, Uchida I et al 1993 Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 52:661-667
33. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM 1994 Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 91:9857-9860
34. Weng NP, Palmer LD, Levine BL, Lane HC, June CH, Hodes RJ 1997 Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol Rev 160:43-54
35. Wick G, Grubeck-Loebenstein B 1997 Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease. Immunol Rev 160:171-184