Impact of aging on gastrointestinal mucosal immunity

Digestive Diseases and Sciences

Volumn 41, Issue 6, 1996, Pages 1183-1193

  Schmucker, Douglas L ^a   Heyworth, Martin F ^b   Owen, Robert L ^b   Daniels, Christopher K ^b  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

Aging; Gut mucosal immunity; IgA; Immunoglobulin A; Immunosenescence; Secretory immunity

Indexed keywords

AGED; AGING; HUMAN; IMMUNITY; PRIORITY JOURNAL; REVIEW; STOMACH MUCOSA;

AGING; ANIMALS; ANTIBODY FORMATION; ANTIBODY-PRODUCING CELLS; GASTRIC MUCOSA; HUMANS; IMMUNITY; IMMUNOGLOBULIN E; INTESTINAL MUCOSA; LYMPHOCYTE SUBSETS; LYMPHOID TISSUE;

EID: 0029998309     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02088236     Document Type: Review

References (76)

1. Makinodan T, Kay M: Age influences on the immune system. Adv Immunol 29:287-330, 1980
2. Schmucker DL, Daniels CK: Aging, gastrointestinal infections and mucosal immunity. J Am Geriatr Soc 34:377-384, 1985
3. Arranz E, Ferguson A: Ageing and gastrointestinal immunity. Eur J Gastroenterol Hepatol 4:1-14, 1992
4. Batory G, Jansco A, Puskas E: Antibody and immunoglobulin levels in aged humans. Arch Gerontol Geriatr 3:175-179, 1984
5. Stowe SP, Redman SR, Segal HL, Stormont JM, Chessin LN, Shah AN, Chey WY: Characteristics and natural history of IBD in the elderly-analysis of Rochester (NY) community. In Inflammatory Bowel Disease. R McDermott (ed). Amsterdam, Elsevier Scientific, 1988, pp 649-654
6. Powers DC: Immunological principles and emerging strategies of vaccination for the elderly. J Am Geriatr Soc 40:81-94, 1992
7. Beyer WE, Palache AM, Baljet M: Antibody induction by influenza vaccines in the elderly: A review of the literature. Vaccine 7:385-394, 1989
8. Waldman RH, Bergmann K, Stone J: Age-dependent antibody response in mice and humans following oral influenza immunization. J Clin Immunol 7:327-332, 1987
9. Ganguly R, Stablein J, Lockey RF: Defective antimicrobial functions of oral secretions in the elderly. J Infect Dis 153:163-164, 1986
10. Strassburg MA, Greenland S, Sorvillo FJ: Influenza in the elderly: Report of an outbreak and a review of vaccine effectiveness reports. Vaccine 4:38-44, 1986
11. Ship JA, Wolff A, Selik RM: Epidemiology of acquired immune deficiency syndrome in persons aged 50 years or older. J Acquir Immune Defic Syndr 4:84-88, 1991
12. Weiler PG, Mungas D, Pomersantz S: AIDS as a cause of dementia in the elderly. J Am Geriatr Soc 36:139-141, 1988
13. Sutin DG, Rose DN, Mulvihill M, Taylor B: Survival of elderly patients with transfusion-related acquired immunodeficiency syndrome. J Am Geriatr Soc 41:214-216, 1993
14. + T cell counts. J Acquir Immune Defic Syndr 4:970-975, 1991
15. Blaxhult A, Granath F, Lidman K, Giesecke J: The influence of age on the latency period to AIDS in people infected by HIV through blood transfusion. J Acquir Immune Defic Syndr 4:125-129, 1990
16. Horan ME: Immunosenescence and mucosal immunity. Lancet 341:793-794, 1993
17. Gross PA, Quinnan GV Jr, Weksler ME: Relation of chronic disease and immune response to influenza vaccine in the elderly. Vaccine 7:303-308, 1989
18. Chandra RK: Mucosal immune responses in malnutrition. Ann NY Acad Sci 409:345-351, 1983
19. Watson RR, McMurray DN, Martin P: Effect of age, malnutrition and renutrition on free secretory component and IgA secretions. Am J Clin Nutr 42:281-288, 1985
20. Ebersole JL, Smith DJ, Taubman MA: Secretory immune responses in aging rats. I. Immunoglobulin levels. Immunology 56:345-350, 1985
21. Amman AJ, Schiffman G, Austrian R: The antibody responses to pneumococcal capsular polysaccharides in aged individuals. Proc Soc Exp Biol Med 164:312-316, 1980
22. Buckley CE, Buckley EG, Dorsey FC: Longitudinal changes in serum immunoglobulin levels in older humans. Proc Soc Exp Biol Med 33:2023-2028, 1974
23. Finkelstein MS, Tanner M, Freedman MC: Salivary and serum IgA levels in a geriatric outpatient population. J Clin Immunol 4:85-89, 1984
24. Arranz E, O'Mahony S, Barton JR, Ferguson A: Immunosenescence and mucosal immunity: Significant effects of old age on secretory IgA concentrations and intraepithelial lymphocyte counts. Gut 33:882-886, 1992
25. Taylor LD, Daniels CK, Schmucker DL: Ageing compromises gastrointestinal mucosal immune response in the rhesus monkey. Immunology 75:614-618, 1992
26. Vajdy M, Lycke NY: Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization. Immunology 75:488-492, 1992
27. Smith D, Ebersole J, Taubman M: Local and systemic immune response in aged hamsters. Immunology 50:407-413, 1983
28. Fujimoto K, Terao K, Cho F: Age-related immunoglobulin levels in cynomolgus monkeys. Jpn J Med Sci Biol 35:17-23, 1981
29. Senda S, Cheng E, Kawanishi H: Aging associated changes in murine intestinal immunoglohulin A and M secretions. Scand J Immunol 27:157-164, 1988
30. Sleffen MJ, Ebersole JL: Effects of aging on antibody avidity to Mycoplasma pulmonis. Mech Aging Dev 78:123-144, 1995
31. Schmucker DL, Daniels CK, Wang RK, Smith K: Mucosal immune response to cholera toxin in ageing rats. I. Antibody and antibody-containing cell response. Immunology 64:691-695, 1988
32. Green-Johnson JM, Haq JA, Szewczuk MR: Effects of aging on the production of cytoplasmic interleukin-4 and -5 and interferon-γ by mucosal and systemic lymphocytes after activation with phytohemagglutinin. Aging Immunol Infect Dis 3:43-57, 1991
33. Kang D, Ohkawa S, Difabio S, Merrill K, Fujihashi K, Yamamoto M, Miller CJ, Mathas M, McGhee JR, Eldridge JH, Murphey-Corb M, Kiyono H: Characterization of T and B cells isolated from mucosa-associated tissues of the rhesus macaque. Cell Immunol 151:379-391, 1993
34. Kawanishi J, Kiely J: Immune related alterations in aged gut-associated lymphoid tissues in mice. Dig Dis Sci 34:175-184, 1989
35. Cornes JS: Number, size and distribution of Peyer's patches in the human small intestine. Gut 6:225-230, 1965
36. Bianchi A, van der Heijden PJ, Stok W, Rozing J, Coolen C: Decrease of IgA-secreting cells in the lamina propria of mice during aging. Aging Immunol Infect Dis 2:241-250, 1990
37. Fleming AL, Field EH, Tolaymat N, Cowdery J: Age influences recovery of systemic and mucosal immune responses following acute depletion of CD4 T cells. Clin Immunol Immunopath 69:285-291, 1993
38. Bienenstock J, Befus D, McDermott M: Regulation of lympho-blastic traffic and localization in mucosal tissues with emphasis on IgA. Fed Proc 42:3213-3217, 1984
39. Haaijman JJ, Schuit HR, Hijmans W: Immunoglobulin-containing cells in different lymphoid organs of the CBA mouse during its lifespan. Immunology 32:427-434, 1977
40. Kawanishi H, Kiely J: Immunoregulatory defects in murine aged Peyer's patches. Eur J Immunol 17:1223-1228, 1987
41. Ebersole JL, Steffen MJ, Pappo J: Secretory immune responses in ageing rats. II. Phenotype distribution of lymphocytes in secretory and lymphoid tissues. Immunology 64:289-294, 1988
42. + cell distribution in gut-associated lymphoid tissues (GALT) of the aging Fischer 344 rat: A correlated immunohistochemical and flow cytometric analysis. Exp Gerontol 28:549-555, 1993
43. Crowley CA, Wade AW, Szewczuk MR: Divergent shifts in T-lymphocyte subpopulations among mucosal lymphoid tissues of mice with increasing age. Ann NY Acad Sci 409:806-807, 1983
44. Ernst DN, Weigle WO, Thoman M: Retention of T cell reactivity to mitogens and alloantigens by Peyer's patch cells of aged mice. J Immunol 138:26-31, 1987
45. Szewczuk MR, Wade AW: Aging and the mucosal-associated lymphoid system. Ann NY Acad Sci 409:333-344, 1983
46. Green-Johnson JM, Szewczuk MR: Proliferative capacity of senescent lymphocytes. II. Monoclonal antibody stimulation of mucosal and systemic lymphocytes via T cell activation molecules, CD3 epsilon, T cell receptor V β chain and phosphati-dylinositol-linked anchored receptors THY-1 and LY-6A.2/TAP.Reg Immunol 3:323-327, 1990
47. Wade AW, Green-Johnson JM, Szewczuk MR: Functional changes in systemic and mucosal lymphocyte repertoires with age: an update review. Aging Immunol Infect Dis 1:65-97, 1988
48. van der Heijden PJ, Bianchi AT, Stok W, Bockhout BA: Background (spontaneous) immunoglobulin production in the murine small intestine as a function of age. Immunology 65:243-248, 1988
49. Szewczuk MR, Campbell RJ, Jung LK: Lack of age-associated immune dysfunction in mucosal-associated lymph nodes. J Immunol 126:2200-2204, 1981
50. Rivier DA, Trefts PE, Kagnoff MF: Age-dependence of the IgA anti-α(1-3) Dextran B1355 response in vitro. Scand J Immunol 17:115-121, 1983
51. Daniels CK, Schmucker DL, Irvin BJ: Differential IgA responses in the aging Fischer rat following mucosal stimulation with cholera toxin or β subunit. Aging Immunol Infect Dis 4:95-107, 1993
52. Mega J, McGhee JR, Kiyono H: Cytokine and Ig-producing cells in mucosal effector tissues: Analysis of IL-5 and IFN-γ-producing T cells, T cell receptor expression and IgA plasma cells from mouse salivary gland-associated tissues. J Immunol 148:2030-2039, 1992
53. Fujihashi K, McGhee JR, Cummins L, Beagley KW, Taga T, Hirano T, Kishimoto T, Mestecky J, Kiyono H: Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis. J Clin Invest 88:248-252, 1991
54. McGhee JR, Mestecky J, Elson CO, Kiyono H: Regulation of IgA synthesis and immune response hy T cells and interleukins. J Clin Immunol 9:175-199, 1989
55. Kono Y, Beagley KW, Fujihashi K, McGhee JR, Mestecky J, Kiyono H: Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-metiated polyclonal IgG and IgA synthesis in inflamed human gingiva. J Immunol 146:181-191, 1991
56. Cowdry JS, Kemp JD, Ballas ZK, Weher SP: Interleukin-1 induces T cell-mediated differentiation of murine Peyer's patch B cells to IgA secretion. Reg Immunol 1:9-14, 1988
57. Stanisz AM, Befus D, Bienenstock J: Differential effects of vasoactive intestinal peptide, substance P and somatostatin on immunoglobulin synthesis and lymphocyte proliferation by lymphocytes from Peyer's patches, mesenterie lymph nodes and spleen. J Immunol 136:152-156, 1986
58. Ottaway CA: Neuroimmunomodulation in the intestinal mucosa. Gastroenterol Clin North Am 20:511-529, 1991
59. Ershler WB: Interleukin-6: a cytokine for gerontologists. J Am Geriatr Soc 41:176-181, 1993
60. Underdown BJ, Schiff JM: Immunoglobulin A: strategic defense initiative at the mucosal surface. Annu Rev Immunol 4:389-417, 1986
61. Daniels CK, Schmucker DL: Secretory component-dependent hinding of immunoglohulin A in the rat, monkey and human: A comparison of intestine and liver. Hepatology 7:517-521, 1987
62. Brown WR, Kloppel TM: The liver and IgA: immunological, cell biological and clinical implications. Hepatology 9:763-784, 1989
63. Brandtzaeg P: Role of J chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man. Scand J Immunol 22:111-146, 1985
64. Larkin JM, Sztul ES, Palade GE: Phosphorylation of the rat hepatic polymeric IgA receptor. Proc Natl Acad Sci USA 83:4759-4763, 1986
65. Casanova JE, Breitfeld PP, Ross SA, Mostov K: Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis. Science 248:742-745, 1991
66. Renston RH, Jones AL, Christianson WD, Hradek GT: Evidence for vesicular transport in hepatocytes for biliary secretion of immunoglobulin A. Science 208:1276-1280, 1980
67. Musil LA, Baenziger J: Cleavage of membrane secretory component to soluble component occurs on the cell surface of rat hepatocyte monolayers. J Cell Biol 104:1725-1733, 1987
68. Lindh E: Increased resistance of immunoglobulin A dimers to proteolytic degradation after binding of secretory component. J Immunol 114:284-286, 1975
69. Schmucker DL, Gilbert R, Jones AL, Hradek GT, Bazin H: Effect of aging on the hepatobiliary transport of dimeric immunoglobulin A in the male Fischer rat. Gastroenterology 88:436-443, 1985
70. Goldman IS, Jones AL, Hradek GT, Huling S: Hepatocyte handling of immunoglobulin A in the rat: the role of microtubules. Gastroenterology 85:130-140, 1983
71. Taylor LD, Jones AL, Schmucker DL: Does aging affect liver microtubules? Proc Soc Exp Biol Med 199:441-445, 1992
72. Daniels CK, Schmucker DL, Jones AL: Age-dependent loss of dimeric immunoglobulin A receptors in the liver of the Fischer 344 rat. J Immunol 134:3855-3858, 1985
73. Gregoire CD, Zhang L, Daniels CK: Expression of the polymeric immunoglobulin receptor by cultured aged rat hepatocytes. Gastroenterology 103:296-301, 1992
74. van Bezooijen RL, Wang RK, Lechner MC, Schmucker DL: Aging affects the regulation of preferentially expressed liver proteins in male Fischer 344 rats. Exp Gerontol 29:186-196, 1994
75. Daniels CK, Schmucker DL, Jones AL: Hepatic asialoglycoprotein receptor-mediated binding of human polymeric immunoglobulin A. Hepatology 9:229-234, 1989
76. Daniels CK, Schmucker DL, Bazin H, Jones AL: Immunoglobulin A receptor of rat small intestinal enterocytes is unaffected by aging. Gastroenterology 94:1432-1440, 1988