Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood

Experimental Gerontology

Volumn 33, Issue 6, 1998, Pages 581-591

  Aspinall, Richard ^a   Carroll, Jennifer ^b   Jiang, Shisonq ^c  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b WHIPPS CROSS UNIVERSITY HOSPITAL   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Activation; Aging; CD95; Lymphocyte subsets; Replication limit

Indexed keywords

FAS ANTIGEN;

ADULT; AGED; AGING; ARTICLE; CELL CULTURE; FEMALE; HUMAN; IMMUNOLOGY; LYMPHOCYTE COUNT; MIDDLE AGED; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; AGING; ANTIGENS, CD95; CELLS, CULTURED; FEMALE; HUMANS; LYMPHOCYTE COUNT; MIDDLE AGED; T-LYMPHOCYTE SUBSETS;

EID: 0032163414     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(98)00035-7     Document Type: Article

References (31)

1. ASPINALL, R. Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J. Immunol. 158, 3037-3045, 1997.
2. BONELLO, R.S., MARCUS, R., BLOCH, D., and STROBER, S. Effects of growth hormone and estrogen on T lymphocytes in older women. J. Am. Geriatr. Soc. 44, 1038-1042, 1996.
3. + T cells throughout life, from newborns to centenarians: implications for T cell memory. Mech. Ageing Dev. 86, 173-195, 1996.
4. EFFROS, R.B. Insights on immunological aging derived from the T lymphocyte cellular senescence model. Exp. Gerontol. 31, 21-27, 1996.
5. EFFROS, R.B. and PAWLEC G. Replicative senescence of T cells: Does the Hayflick limit lead to immune exhaustion? Immunol. Today 18, 450-454, 1997.
6. FOAD, B.S., ADAMS, L.E., YAMAUCHI, Y., and LITWIN, A. Phytomitogen responses of peripheral blood lymphocytes in young and older subjects. Clin. Exp. Immunol. 17, 657-664, 1974.
7. HANNET, I., ERKELLER YUKSEL, F., LYDYARD, P., DENEYS, V., and DEBRUYERE, M. Developmental and maturational changes in human blood lymphocyte subpopulations [see comments]. Immunol. Today 13, 215-218, 1992.
8. + T cells from young and old mice. J. Immunol. 150, 3602-3614, 1993.
9. HULSTAERT, F., HANNET, I., DENEYS, V., MUNHYESHULI, V., REICHERT, T., DEBRUYERE, M., and STRAUSS, K. Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements. Clin. Immunol. Immunopathol. 70, 152-158, 1994.
10. ITOH, N., YONEHARA, S., ISHII, A., YONEHARA, M., MIZUSHIMA, S., SAMESHIMA, M., HASE, A., SETO, Y., and NAGATA, S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66, 233-243, 1991.
11. KENDALL, M.D., JOHNSON, H.R., and SINGH, J. The weight of the human thymus gland at necropsy. J. Anat. 130, 483-497, 1980.
12. + T-lymphocyte regeneration after intensive chemotherapy [see comments]. N. Engl. J. Med. 332, 143-149, 1995.
13. MILLER, R.A. Accumulation of hyporesponsive, calcium extruding memory T cells as a key feature of age-dependent immune dysfunction. Clin. Immunol. Immunopathol. 58, 305-317, 1991.
14. MIYAWAKI, T., UEHARA, T., NIBU, R., TSUJI, T., YACHIE, A., YONEHARA, S., and TANIGUCHI, N. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J. Immunol. 149, 3753-3758, 1992.
15. NAGEL, J.E., CHOPRA, R.K., CHREST, F.J., MCCOY, M.T., SCHNEIDER, E.L., HOLBROOK, N.J., and ADLER, W.H. Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J. Clin. Invest. 81, 1096-1102, 1988.
16. + TCR2+ cultured T cell clones. Exp. Gerontol. 31, 655-658, 1996.
17. PERILLO, N.L., NAEIM, F., WALFORD, R.L., and EFFROS, R.B. The in vitro senescence of human T lymphocytes: Failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype. Mech. Ageing Dev. 67, 173-185, 1993.
18. SCHWAB, R., HAUSMAN, P.B., RINNOOY KAN, E., and WEKSLER, M.E. Immunological studies of ageing. X. Impaired T lymphocytes and normal monocyte response from elderly humans to the mitogenic antibodies OKT3 and Leu 4. Immunology 55, 677-684, 1985.
19. SCOLLAY, R.G., BUTCHER, E.C., and WEISSMAN, I.L. Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur. J. Immunol. 10, 210-218, 1980.
20. + T cells, and monocytes. Cell Immunol. 163, 303-308, 1995.
21. SINGER, G.G. and ABBAS, A.K. The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1, 365-371, 1994.
22. SUDA, T., TAKAHASHI, T., GOLSTEIN, P., and NAGATA, S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75, 1169-1178, 1993.
23. TANCHOT, C., LEMONNIER, F.A., PERARNAU, B., FREITAS, A.A., and ROCHA, B.B. Differential requirements for survival and proliferation of CD8 Naive and memory T cells. Science 276, 2057-2062, 1997.
24. VAN PARIJS, L., and ABBAS, A.K. Role of Fas-mediated cell death in the regulation of immune responses. Curr. Opin. Immunol. 8, 355-361, 1996.
25. WATANABE FUKUNAGA, R., BRANNAN, C.I., COPELAND, N.G., JENKINS, N.A., and NAGATA, S. Lympho-proliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317, 1992.
26. WENG, N.P., LEVINE, B.L., JUNE, C.H., and HODES, R.J. Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. USA 92, 11091-11094, 1995.
27. WITKOWSKI, J.M., LI, S.P., GORGAS, G., and MILLER, R.A. Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production. J. Immunol. 153, 658-665, 1994.
28. XU, X., BECKMAN, I., AHERN, M., and BRADLEY, J. A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry. Immunol. Cell Biol. 71, 549-557, 1993.
29. YONEHARA, S., ISHII, A., and YONEHARA, M. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169, 1747-1756, 1989.
30. ZHOU, T., EDWARDS, C.K., and MOUNTZ, J.D. Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice J. Exp. Med. 182, 129-137, 1995.
31. ZOLA, H., FLEGO, L., MACARDLE, P.J., DONOHOE, P.J., RANFORD, J., and ROBERTSON, D. The CD45RO (p180, UCHL1) marker: Complexity of expression in peripheral blood. Cell. Immunol. 145, 175-186, 1992.