Differential Responses of Skin Cancer-Chemopreventive Agents Silibinin, Quercetin, and Epigallocatechin 3-Gallate on Mitogenic Signaling and Cell Cycle Regulators in Human Epidermoid Carcinoma A431 Cells

Nutrition and Cancer

Volumn 39, Issue 2, 2001, Pages 292-299

  Bhatia, Neehar ^a   Agarwal, Chapla ^a   Agarwal, Rajesh ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CATECHIN; CDK2 PROTEIN; CDKN1B; CELL CYCLE PROTEIN; CIP1 PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASES; CYCLINE; DRUG DERIVATIVE; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIGALLOCATECHIN GALLATE; EXTRACELLULAR SIGNAL-REGULATED KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASES; MITOGENIC AGENT; P34PSK J3 KINASE; P34PSK-J3 KINASE; PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASES; PROTEIN SHC; QUERCETIN; SILYMARIN; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE; COMPARATIVE STUDY; DRUG EFFECT; HUMAN; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN TUMOR; SQUAMOUS CELL CARCINOMA;

ANTICARCINOGENIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CATECHIN; CELL CYCLE; CELL CYCLE PROTEINS; COMPARATIVE STUDY; CYCLIN D1; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; HUMAN; MITOGEN-ACTIVATED PROTEIN KINASES; MITOGENS; P42 MAP KINASE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; QUERCETIN; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SILYMARIN; SKIN NEOPLASMS; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0035226608     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/S15327914nc392_20     Document Type: Article

References (46)

1. Birt, DF, Pelling, JC, Nair, S, and Lepley, D: Diet intervention for modifying cancer risk. Prog Clin Biol Res 395, 223-234, 1996.
2. Hong, WK, and Sporn, MB: Recent advances in chemoprevention of cancer. Science 278, 1073-1077, 1997.
3. Dragsted, LO: Natural antioxidants in chemoprevention. Arch Toxicol Suppl 20, 209-226, 1998.
4. 1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention. Proc Natl Acad Sci USA 96, 7490-7495, 1999.
5. Katiyar, SK, Korman, NJ, Mukhtar, H, and Agarwal, R: Protective effects of silymarin against photocarcinogenesis in mouse skin model. JNCI 89, 556-566, 1997.
6. Agarwal, R, Katiyar, SK, Lundgren, DW, and Mukhtar, H: Inhibitory effect of silymarin, an antihepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal omithine decarboxylase activity and mRNA in SENCAR mice. Carcinogenesis 15, 1099-1103, 1994.
7. Zhao, J, Lahiri-Chatterjee, M, Sharma, Y, and Agarwal, R: Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Carcinogenesis 21, 811-816, 2000.
8. Lahiri-Chatterjee, M, Katiyar, SK, Mohan, RR, and Agarwal, R: A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in SENCAR mouse skin tumorigenesis model. Cancer Res 59, 622-632, 1999.
9. Zhao, J, Sharma, Y, and Agarwal, R: Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of anti-oxidant and inflammatory enzymes, and cyclooxygenase-2 and interleukin-1α expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion. Mol Carcinog 26, 321-333, 1999.
10. Ahmad, N, Gali, H, Javed, S, and Agarwal, R: Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression. Biochem Biophys Res Commun 247, 294-301, 1998.
11. Bhatia, N, and Agarwal, R: Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells. Prostate 46, 98-107, 2001.
12. Zi, X, and Agarwal, R: Modulation of mitogen-activated protein kinase activation and cell cycle regulators by the potent skin cancer preventive agent silymarin. Biochem Biophys Res Commun 263, 528-536, 1999.
13. 1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells. Cancer Res 58, 1920-1929, 1998.
14. Damianaki, A, Bakogeorgou, E, Kampa, M, Notas, G, Hatzoglou, A, et al.: Potent inhibitory action of red wine polyphenols on human breast cancer cells. J Cell Biochem 78, 429-441, 2000.
15. Li, W, Shen, F, and Weber, G: Ribavirin and quercetin synergistically downregulate signal transduction and are cytotoxic in human ovarian carcinoma cells. Oncol Res 11, 243-247, 1999.
16. Ferry, DR, Smith, A, Malkhandi, J, Fyfe, DW, deTakats, PG, et al.: Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res 2, 659-668, 1996.
17. Wang, IK, Lin-Shiau, SY, and Lin, JK: Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 35, 1517-1525, 1999.
18. Richter, M, Ebermann, R, and Marian, B: Quercetin-induced apoptosis in colorectal tumor cells: possible role of receptor signaling. Nutr Cancer 34, 88-99, 1999.
19. Huang, YT, Hwang, JJ, Lee, PP, Ke, FC, Huang, JH, et al.: Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. Br J Pharmacol 128, 999-1010, 1999.
20. Yang, CS, and Wang, ZY: Tea and cancer. JNCI 85, 1038-1049, 1993.
21. Katiyar, SK, Ahmad, N, and Mukhtar, H: Green tea and skin. Arch Dermatol 136, 989-994, 2000.
22. Yang, Y, Liao, J, Kim, K, Yurkow, EJ, and Yang, CS: Inhibition of growth and induction of in human cancer cell lines by tea polyphenols. Carcinogenesis 19, 611-616, 1998.
23. Liang, Y, Chen, Y, Lin, Y, Lin-Shiau, S, Ho, C, et al: Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3.3′-digallate. Carcinogenesis 20, 733-736, 1999.
24. Stratton, SP, Dorr, RT, and Alberts, DS: The state-of-the-art in chemoprevention of skin cancer. Eur J Cancer 36, 1292-1297, 2000.
25. Gensler, HL, Timmermann, BN, Valcic, S, Wachter, GA, Dorr, R, et al.: Prevention of photocarcinogenesis by topical administration of pure epigallocatechin gallate isolated from green tea. Nutr Cancer 26, 325-335, 1996.
26. Barthelman, M, Bair, WB, Stickland, KK, Chen, W, Timmermann, BN, et al.: (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity. Carcinogenesis 19, 2201-2204, 1998.
27. Dong, Z, Ma, W, Huang, C, and Yang, CS: Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin-3 gallate, and theaflavins. Cancer Res 57, 4414-4419, 1997.
28. Katiyar, SK, Perez, A, and Mukhtar, H: Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA. Clin Cancer Res 6, 3864-3869, 2000.
29. Agarwal, R, Katiyar, SK, Zaidi, SI, and Mukhtar, H: Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives. Cancer Res 52, 3582-3588, 1992.
30. Yoshizawa, S: (-)-Epigallocatechin gallate, the main constituent of Japanese green tea, inhibits tumor promotion of okadaic acid. Fukuoka Igahi Zasshi 87, 215-221, 1996. [In Japanese]
31. Ahmad, N, Feyes, DK, Nieminen, A, Agarwal, R, and Mukhtar, H: Green tea constituent epigallocatechin-3 gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. JNCI 89, 1881-1886, 1997.
32. Paschka, AG, Butler, R, and Young, CYF: Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3 gallate. Cancer Lett 130, 1-7, 1998.
33. Levitzki, A, and Gazit, A: Tyrosine kinase inhibition: an approach to drug development. Science 267, 1782-1788, 1995.
34. Hunter, T, and Cooper, JA: Protein tyrosine kinases. Annu Rev Biochem 54, 897-930, 1985.
35. Kelloff, GJ, Fay, JR, Steele, VE, Lubet, RA, Boone, CW, et al.: Epidermal growth factor receptor tyrosine kinase inhibitors as potential cancer chemopreventives. Cancer Epidemiol Biomarkers Prev 5, 657-666, 1996.
36. Pentland, AP: Signal transduction mechanisms in photocarcinogenesis. Pholochem Photobiol 63, 379-380, 1996.
37. Xian, W, Kiguchi, K, Imamoto, A, Rupp, T, Zilberstein, A, et al.: Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice. Cell Growth Differ 6, 1447-1455, 1995.
38. Warmuth, I, Harth, Y, Matsui, MS, Wang, N, and DeLeo, VA: Ultraviolet radiation induces phosphorylation of the epidermal growth factor receptor. Cancer Res 54, 374-376, 1994.
39. Irani, K, Xia, Y, Zweier, JL, Sollott, Si, Der, CJ, et al.: Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts. Science 275, 1649-1652, 1997.
40. p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J 15, 3621-3632, 1996.
41. Gioeli, D, Mandell, JW, Petroni, GR, Frierson, HF, Jr, and Weber, MJ: Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Res 59, 279-284, 1999.
42. Ware, JL: Growth factors and their receptors as determinants in the proliferation and metastasis of human prostate cancer. Cancer Metastasis Rev 12, 287-301, 1993.
43. Grana, X, and Reddy, P: Cell cycle control in mammalian cells: role of cyclins, cyclin-dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CDKIs). Oncogene 11, 211-219, 1995.
44. Weinstein, IB: Relevance of cyclin D1 and other molecular markers to cancer chemoprevention. J Cell Biochem 25S, 23-28, 1996.
45. Hunter, T, and Pines, J: Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age. Cell 79, 573-582, 1994.
46. Zi, X, Mukhtar, H, and Agarwal, R: Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNFα. Biochem Biophys Res Commn 239, 334-339, 1997.