Regulation of cell function by Rho GTPases

Drug News and Perspectives

Volumn 14, Issue 7, 2001, Pages 389-395

  DerMardirossian, C ^a   Bokoch, G M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; APOPTOSIS; CELL FUNCTION; CELL GROWTH; DRUG ACTIVITY; DRUG TARGETING; GENETIC TRANSCRIPTION; MODEL; MOUSE; NONHUMAN; REGULATORY MECHANISM; REVIEW;

EID: 0035207550     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2001.14.7.858421     Document Type: Review

References (52)

1. Proteins regulating Ras and its relatives
2. Rho GTPases and signaling networks
3. Small GTP-binding proteins
4. Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42
5. Increased neutrophil respiratory burst in BCR null mutants
6. Rho as a regulator of the cytoskeleton
7. Rho GTPases and the actin cytoskeleton
8. Rho: A connection between membrane receptor signaling and the cytoskeleton
9. Rho GTPases and their effector proteins
10. Rho GTPases control polarity, protrusion and adhesion during cell movement
11. Positive feedback interactions between microtubule and actin dynamics during cell motility
12. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
13. Regulation of receptor-mediated endocytosis by Rho and Rac
14. Interleukin 2 receptor and detergent-resistant membrane domains define a clathrin-independent endocytic pathway
15. The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways
16. Phospholipid signaling: Rho is only ARF the story
17. ARF mediates recruitment of PtdIns-4-OH kinasebeta and stimulated synthesis of PtdIns (4,5)P2 on the golgi complex
18. An essential role for Rac in Ras transformation
19. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
20. The protein kinase Pak3 positively regulates Raf-1 activity through phoshorylation of serine 338
21. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
22. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
23. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
24. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
25. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
26. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins
27. The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes
28. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphochytes and Fas
29. Suppression of Ras-induced apoptosis by the Rac GTPase
30. p21-activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis
31. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
32. NADPH oxidase: An update
33. Translocation of guinea pig p40-phox during activation NADPH oxidase
34. Regulation of the phagocyte respiratory burst by small GTP-binding proteins
35. Biologically active lipids are regulators of Rac: GDI complexation
36. Translocation of Rac correlates with NADPH oxidase activation: Evidence for equimolar translocation of oxidase components
37. Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors
38. Targeting of RacI to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly
39. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
40. Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins
41. Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI
42. Phosphorylation of Rho GDI stabilizes the Rho A-Rho GDI complex in neutrophil cytosol
43. Phosphoinositide-dependent activation of Rho A involves partial opening of the RhoA/Rho-GDI complex
44. Regulation af NADPH oxidase activity by Rac GTPase activating protein(s)
45. Molecular basis for Rac2 regulation of phagocyte NADPH oxidase
46. Interaction between Cdc42Hs and RhoGDI is mediated through the Rho insert region
47. Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules
48. The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
49. GTPase-activating proteins: Helping hands to complement an active site
50. Invasion of the nucleotide snatchers: Structural insights into the mechanism of G protein GEFs
51. Brefeldin A: The advantage of being uncompetitive
52. Potential drug targets: Small GTPases that regulate leukocyte function