Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistance

Diabetes

Volumn 50, Issue 3, 2001, Pages 643-651

  Castellani, Lawrence W ^a,b   Goto, Aimie M ^a   Lusis, Aldons J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A2; DEOXYGLUCOSE; FATTY ACID; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; GLUCOSE METABOLISM; HOMEOSTASIS; HYDROLYSIS; INSULIN RESISTANCE; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE;

EID: 0035123369     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.3.643     Document Type: Article

References (56)

1. An overview of reverse cholesterol transport
2. Overexpression of apolipoprotein A-II in transgenic mice converts high density lipoproteins to proinflammatory particles
3. Cholesterol efflux from cultured adipose cells is mediated by LpA-1 particles but not by LpAI:A-II particles
4. Cholesterol esters selectively delivered in vivo by high-density-lipoprotein subclass LpA-to rat liver are processed faster into bile acids than are LpA-I/A-II-derived cholesterol esters
5. Apolipoprotein A-I deficiency due to a codon 84 nonsense mutation of the apolipoprotein A-I gene
6. Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II
7. Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice
8. Protein composition determines the anti-atherogenic properties of HDL in transgenic mice
9. Influence of the apoA-II gene locus on HDL levels and fatty streak development in mice
10. Evidence for linkage of the apolipoprotein A-II locus to plasma apolipoprotein A-II and free fatty acid levels in mice and humans
11. Banting Lecture 1988: Role of insulin resistance in human disease
12. Genetic and environmental architecture of the features of the insulin-resistance syndrome
13. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
14. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
15. Experimental strategies for the genetic dissection of complex traits in animal models
16. A polymorphism affecting apolipoprotein A-II translational efficiency determines high density lipoprotein size and composition
17. Linkage analysis of the genetic determinants of high density lipoprotein concentrations and composition: Evidence for involvement of the apolipoprotein A-II and cholesteryl ester transfer protein loci
18. Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility
19. BSB: A new mouse model of multigenic obesity
20. Enzymatic methods for quantification of lipoprotein lipids
21. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
22. A simple method for the isolation and purification of total lipids from animal tissues
23. Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice
24. Glucose transport into rat skeletal muscle: Interaction between exercise and insulin
25. Synthesis of hepatic lipase in liver and extrahepatic tissues
26. Glucose homeostasis in the nonobese diabetic mouse at the prediabetic stage
27. Insulin resistance in the regulation of lipolysis and ketone body metabolism in non-insulin dependent diabetes is apparent at very low insulin concentrations
28. Insulin promotes the biosynthesis and secretion of apolipoprotein B-48 by altering apolipoprotein B mRNA editing
29. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
30. Regulation of glucose uptake by muscle
31. Fuel selection in animals
32. The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
33. Relationship between insulin-mediated glucose disposal and lipid metabolism in man
34. Role of lipid oxidation in the pathogenesis of insulin resistance of obesity and type II diabetes
35. Contribution of muscle and liver to the glucose-fatty acid cycle in humans
36. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: A study of 24 hr RQ
37. Relationship between skeletal muscle lipoprotein lipase activity and 24-hour macronutrient oxidation
38. Skeletal muscle utilization of free fatty acids in women with visceral obesity
39. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women
40. Influence of dietary fat composition on development of insulin resistance in rats: Relationship to muscle triglyceride and w-3 fatty acids in muscle phospholipids
41. Scavenger receptor family proteins: Roles for atherosclerosis, host defence, and disorders of the central nervous system
42. Expression of the CD36 homolog (FAT) in fibroblast cells: Effects on fatty acid transport
43. Oxidized low density lipoprotein-induced activation of NF-kB and subsequent expression of a variety of proinflammatory and proatherogenic genes are defective in monocyte-drived macrophages from CD36-deficient mice
44. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
45. Muscle specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin
46. Impaired glucose tolerance in the U.S. population
47. Coronary heart disease risk and impaired glucose toleracne: The Whitehall Study
48. Prevalence of complications among second-generation Japanese-American men with diabetes, impaired glucose tolerance, or normal glucose tolerance
49. Pathogenesis of age-related glucose intolerance in man: Insulin resistance and decreased beta-cell function
50. Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of type II diabetes mellitus; NSY mouse
51. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
52. Relation of high plasma triglyceride levels associated with obesity and regional adipose tissue distribution to plasma lipoprotein-lipid composition in premenopausal women
53. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease
54. What if Minkowski had been ageusic? An alternative angle on diabetes
55. Sequence analysis of candidate genes in a region of chromosome I linked to type 2 diabetes
56. Genome-wide search for type 2 diabetes susceptibility genes in Caucasians: Evidence for a recessive locus on chromosome 1