Adenosine A2A receptor antagonists: Potential therapeutic neuroprotective effects in parkinson's disease

Neurotoxicity Research

Volumn 3, Issue 6, 2001, Pages 545-556

  Morelli, M ^a   Wardas, J ^b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Adenosine A2A receptor antagonists; Dopamine D1 and D2 receptors; Dyskinesia; Neuroprotection; Parkinson's disease; Striatum; Turning behavior

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,7 DIMETHYL 1 PROPARGYLXANTHINE; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; ADENOSINE RECEPTOR BLOCKING AGENT; BROMOCRIPTINE; DOPAMINE RECEPTOR STIMULATING AGENT; EXCITOTOXIN; HALOPERIDOL; ISTRADEFYLLINE; LEVODOPA; OXIDOPAMINE; RESERPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NERVE CELL; CATALEPSY; CONTROLLED STUDY; CORPUS STRIATUM; DISABILITY; DISEASE SEVERITY; DRUG ACTIVITY; DRUG EFFICACY; DRUG TOLERANCE; DRUG UTILIZATION; DYSKINESIA; HUMAN; IMMUNOREACTIVITY; LONG TERM CARE; MARMOSET; MONKEY; MOTOR DYSFUNCTION; MOUSE; NERVE CELL DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIMATE; PRIORITY JOURNAL; PSYCHOSIS; RAT; RIGIDITY; SCORING SYSTEM;

ANIMALIA; MACACA FASCICULARIS; MARMOSETS; PRIMATES;

EID: 0035195117     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033210     Document Type: Article

References (87)

1. 2A receptor antagonist"
2. 2a receptors in the nucleus accumbens mediate locomotor depression"
3. "Neonatal cerebral hypoxia ischemia: The effect of adenosine receptor antagonists"
4. "Relationship between rotational behaviour induced by apomorphine and caffeine in rats with unilateral lesion of the nigrostriatal pathway"
5. 2A adenosine receptors deficiency attenuate brain injury induced by transient focal ischemia in mice"
6. 2 receptor knockout mice"
7. "Neuroprotection by caffeine and A2A adenosine receptor inactivation in a model of Parkinson's Disease"
8. 2 receptors in stably cotransfected cells"
9. 2A receptor in the striatum"
10. 2 receptor involvement in the hypomobility effects of adenosine analogues in mice"
11. 2 receptors"
12. 2A receptor antagonism potentiates L-DOPA-induced turning behaviour and c-fos expression in 6-hydroxydopamine-lesioned rats"
13. "Adenosine-dopamine interactions in the ventral striatum. Implications for the treatment of schizophrenia"
14. "Stimulation of high affinity adenosine A-2 receptors decreases the affinity of dopamine D-2 receptors in rat striatal membranes"
15. "Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia"
16. 2 dopamine receptors in rat striatum"
17. "Adenosine receptors"
18. "Actions of caffeine in the brain with special reference to factors that contribute to its widespread use"
19. "Action of caffeine and theophyllamine on supersensitive dopamine receptors: Considerable enhancement of receptor response to treatment with DOPA and dopamine receptor agonists"
20. "CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischaemic injury in the Mongolian gerbil"
21. "The role of dopamine in the behavioral effects of caffeine in animals and humans"
22. 2 dopamine receptor antagonists block caffeine-induced stimulation of locomotor activity in rats"
23. 2 receptor agonists but not to their synergistic interaction"
24. "D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons"
25. "Comparison of the behavioral effects of an adenosine A1/A2-receptor antagonist, CGS 5943A, and an A1-selective antagonist, DPCPX"
26. 2A receptor antagonist in MPTP-treated monkeys"
27. 2A receptors in the caudate-putamen"
28. "Comparison of the behavioral effects of adenosine agonists and dopamine antagonists in mice"
29. "Characterisation of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease"
30. "Caffeine produces contralateral rotation in rats with unilateral dopamine denervation: Comparisons with apomorphine-induced responses"
31. "Correlation between hippocampal injury and neurobehavior following normo- and hyperglycemic cerebral ischemia, effect of theophylline and ZM241385"
32. "CGS 15943, a non xanthine adenosine receptor antagonist: Effects on locomotor activity of non tolerant and caffeine-tolerant rats"
33. 2A receptor mRNA expression in Parkinson's disease"
34. 2-selective agonist, [3H]CGS 21680"
35. "Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats"
36. 2A receptor antagonist"
37. 2A receptor agonists and antagonists"
38. "Behavioral effects of intrastriatal caffeine mediated by adenosinergic modulation of dopamine"
39. 2 receptor interactions in animal models of schizophrenia"
40. 2A antagonist with anticataleptic activity"
41. 2A antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys"
42. "Studies with bromocriptine III. Concomitant administration of caffeine to patients with idopathic parkinsonism"
43. 2a receptor-mediated modulation of striatal [3H]GABA and [3H]Acetylcholine release"
44. "Inhibition by KF 17837 of adenosine receptor-mediated modulation of striatal GABA and ACh release"
45. 2A receptor agonist and antagonist"
46. "Potential role of adenosine antagonist therapy in pathological tremor disorders"
47. "Adenosine A2 receptors modulate haloperidol-induced catalepsy in rats"
48. 2 receptors: Selective localization in the human basal ganglia and alterations with disease"
49. "Adenosine: Does it have a neuroprotective role after all?"
50. 1 receptor-mediated effects on c-foc expression"
51. 2A adenosine receptors by SCH 58261 results in neuroprotective effect in cerebral ischemia in mice"
52. 2A adenosine receptor antagonists in relevant rodent models"
53. 2 receptors in unilaterally 6-hydroxydopamine-lesioned rats"
54. 2 receptors stimulate c-fos expression in striatal neurons of 6-hydroxydopamine-lesioned rats"
55. 2A receptors in regulating GABAergic synaptic transmission in striatal medium spiny neurons"
56. "The role of receptor structure in determining adenosine receptor activity"
57. 2A receptors"
58. 2A adenosine receptors: An apparent paradox"
59. 2A receptors"
60. "The selective A2 agonist CGS 21680 enhances excitatory transmitter amino acid release from the ischemic rat cerebral cortex"
61. 2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil"
62. 1 agonists in dopamine-denervated rats"
63. 2A receptor antagonist SCH 58261 do not develop tolerance after repeated treatments in 6-hydroxydopamine-lesioned rats"
64. 1 dopamine agonist on rotational behaviour and striatal c-Fos induction in 6-hydroxydopamine-lesioned rats"
65. "Modulation of striatal adenosine A1 and A2 receptors induces rotational behavior in response to dopaminergic stimulation in intact rats"
66. 2A receptor stimulation enhances striatal extracellular glutamate levels in rats"
67. 2A receptor antagonists as new agents for the treatment of Parkinson's disease"
68. 2A agonists: A potential new type of atypical antipsychotics"
69. 2A receptors in the rat central nervous system"
70. "Association of coffee and caffeine intake with the risk of Parkinson disease"
71. "Neuroprotective role of adenosine in cerebral ischaemia"
72. "Interaction between caffeine and cocaine in tests of self-administration"
73. "The striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons. An in situ hybridization histochemistry study"
74. 2A receptor-mediated excitatory actions on the nervous system"
75. "Fine-tuning neuromodulation by adenosine"
76. 2A receptor agonist CGS 21680"
77. 2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP"
78. "Caffeine and the antiparkinsonian response to levodopa or pirebidil"
79. "Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: Effects of adenosine receptor agonists and antagonists"
80. 2A receptor regulation in the rat dopamine-denervated striatum"
81. "Adenosine receptors, kynurenines and neuroprotection"
82. "Distribution of adenosine receptors in the postmortem human brain: An extended autoradiographic study"
83. 2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens"
84. "Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigrostriatal dopamine system"
85. 2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation"
86. 2 receptors"
87. 2A adenosine receptor antagonist"