Functional uncoupling of adenosine A(2A) receptors and reduced response to caffeine in mice lacking dopamine D2 receptors

Journal of Neuroscience

Volumn 20, Issue 16, 2000, Pages 5949-5957

  Zahniser, Nancy R ^a   Simosky, Johanna K ^a   Mayfield, R Dayne ^a   Negri, Cori A ^a   Hanania, Taleen ^a   Larson, Gaynor A ^a   Kelly, Michele A ^b   Grandy, David K ^b   Rubinstein, Marcelo ^c   Low, Malcolm J ^b   Fredholm, Bertil B ^d  

^a UNIVERSITY OF COLORADO   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adenosine A(2A) receptor; c fos; Caffeine; cAMP stimulation; CGS 21680; D2 receptor knock out mouse; Dopamine D2 receptor; G(olf); G(s); GABA release; Locomotor activity; mRNA; Striatopallidal pathway; Type VI adenylyl cyclase; 3H CGS 21680; 3H SCH 58261

Indexed keywords

ADENOSINE A2 RECEPTOR; CAFFEINE; DOPAMINE 2 RECEPTOR;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; COUPLING FACTOR; GENE DISRUPTION; GLOBUS PALLIDUS; LOCOMOTION; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR GENE; STIMULUS RESPONSE; SYNAPTOSOME;

EID: 0034663289     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-16-05949.2000     Document Type: Article

References (57)

1. 2 receptors
2. Immunohistochemical localization of caffeine-induced c-Fos protein expression in rat brain
3. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
4. Regulation of adenylyl cyclase type VI activity during desensitization of the A2a adenosine receptor-mediated cyclic AMP response: Role of protein phosphatase 2A
5. Mechanism of action of caffeine
6. Calculating receptor number from binding experiments using the same compound as radioligand and competitor
7. 2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum
8. 2 receptors
9. 2-mediated behaviour in short-term reserpinized mice
10. Adenosine-dopamine interactions in the brain
11. The striatopallidal neuron: A main locus for adenosine-dopamine interactions in the brain
12. 1 receptor-mediated mechanisms
13. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia
14. 1 receptors in stably cotransfected fibroblast cells
15. 2 dopamine receptors in rat striatum
16. Adenosine, adenosine receptors and the actions of caffeine
17. 3H]SCH 58261, A selective adenosine A(2A) receptor antagonist, is a useful ligand in autoradiographic studies
18. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use
19. 2 dopamine receptor antagonists block caffeine-induced stimulation of locomotor activity in rats
20. The neostriatal mosaic: Multiple levels of compartmental organization
21. Cloning and expression of an adenylyl cyclase localized to the corpus striatum
22. A postsynaptic interaction between dopamine D1 and NMDA receptors promotes presynaptic inhibition in the rat nucleus accumbens via adenosine release
23. Motor effects induced by a blockade of adenosine A(2A) receptors in the caudate-putamen
24. 1 receptor with adenylyl cyclase
25. 2 receptor activation on electrically evoked dopamine and acetylcholine release from rat striatal slices
26. Effects of mono- and divalent ions on the binding of the adenosine analogue CGS 21680 in rat striatum
27. Long-term treatment with some methylxanthines decreases the susceptibility to bicuculline- and pentylenetetrazol-induced seizures in mice. Relationship to c-fos expression and receptor binding
28. Distribution and postnatal ontogeny of adenosine A(2A) receptors in rat brain: Comparison with dopamine receptors
29. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory epithelium
30. G(olf): An olfactory neuron-specific G-protein involved in odorant signal transduction
31. 2 receptor-deficient mice
32. 2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations
33. 2 receptor agonist in mice
34. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
35. 1 receptor-mediated effects on c-fos expression
36. 2 receptor-deficient mice
37. Expression of type VI adenylyl cyclase in the central nervous system: Implication for a potential regulator of multiple signals in different neurotransmitter systems
38. μ(2c)-Adrenoceptors mediate inhibition of forskolin-stimulated cAMP production in rat striatum
39. Effects of the selective adenosine A2 receptor agonist CGS 21680 on in vitro electro-physiology, cAMP formation and dopamine release in rat hippocampus and striatum
40. Endogenous GABA release from rat striatal slices: Effects of the GABA(B) receptor antagonist 2-hydroxysaclofen
41. Adenosine A(2a) receptor modulation of electrically evoked endogenous GABA release from slices of rat globus pallidum
42. 2 receptor interaction in globus pallidus
43. Central adenosine A(2A) receptors: An overview
44. Caffeine-induced locomotor activity: Possible involvement of GABAergic-dopaminergic-adenosinergic interaction
45. Pharmacology of adenosine A(2A) receptors
46. Adenosine A2 receptors regulate gene expression of striatopallidal and striatonigral neurons
47. 2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: An in situ hybridization histochemistry study
48. 2 receptor-mediated excitatory actions on the nervous system
49. Preferential effects of caffeine on limbic and cortical dopamine systems
50. Caffeine mimics the effect of a dopamine D(2/3) receptor agonist on the expression of immediate early genes in globus pallidus
51. Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine
52. Antagonism of adenosine A(2A) receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens
53. Cellular expression of adenosine A(2A) receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas
54. Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons
55. Convenient elimination of trichloroacetic acid prior to radioimmunoassay of cyclic nucleotides
56. Regulation of striatal cyclic-3',5'-adenosine monophosphate accumulation and GABA release by glutamate metabotropic and dopamine D1 receptors