Actions of adenosine A(2A) receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP

Psychopharmacology

Volumn 147, Issue 1, 1999, Pages 90-95

  Shiozaki, Shizuo ^a   Ichikawa, Shunji ^a   Nakamura, Joji ^a   Kitamura, Shigeto ^a   Yamada, Koji ^a   Kuwana, Yoshihisa ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Adenosine A(2A) receptor; Antagonist; Caffeine; Catalepsy; Hypolocomotion; L Dopa; MPTP; Parkinson's disease; Reserpine

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 1,3 DIETHYL 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR ANTAGONIST; CAFFEINE; HALOPERIDOL; ISTRADEFYLLINE; LEVODOPA; RESERPINE; THEOPHYLLINE; UNCLASSIFIED DRUG; ADENOSINE; ADENOSINE RECEPTOR; ANTIPARKINSON AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; NEUROLEPTIC AGENT; PHENETHYLAMINE DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; PURINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG POTENCY; DRUG POTENTIATION; HYPOKINESIA; MALE; MOUSE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; MOTOR ACTIVITY;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ADENOSINE; ANIMALS; ANTIPARKINSON AGENTS; ANTIPSYCHOTIC AGENTS; CAFFEINE; CATALEPSY; DOPAMINE AGENTS; HYPOKINESIA; LEVODOPA; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; PHENETHYLAMINES; PHOSPHODIESTERASE INHIBITORS; PURINES; RECEPTORS, PURINERGIC P1; RESERPINE; THEOPHYLLINE;

EID: 0033219932     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130051146     Document Type: Article

References (34)

1. Colpaert FC (1987) Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat. Neuropharmacology 26:1431-1440
2. Davis CG, Williams AC, Markey, SP, Ebert MH, Caine ED, Reichert CM, Kopin IJ (1979) Chronic parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatry Res 1:249-254
3. 2A receptor antagonism potentiates L-dopa-induced turning behavior and c-fos expression in 6-hydroxydopamine-lesioned rats. Eur J Pharmacol 321:143-147
4. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P Williams M (1994) Nomenclature and classification of purinoceptors. Pharmacol Rev 46:143-156
5. Fredriksson A, Plaznik A, Sundstrom E, Jonsson G, Archer T (1990) MPTP-induced hypoactivity in mice: reversal by L-dopa. Pharmacol Toxicol 67:295-301
6. Haley TJ, McCormack WG (1957) Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br J Pharmacol 12:12
7. Heikkila R, Cabbat L, Manzino L, Duvoisin RC (1984a) Effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine on neostriatal dopamine in mice. Neuropharmacology 23:711-713
8. Heikkila RE, Manzino L, Cabbat FS, Duvoisin RC (1984b) Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 311:467-469
9. 2A receptor antagonist with anticataleptic activity. Eur J Pharmacol 256:264-268
10. 2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys. Ann Neurol 43:507-513
11. Kawaguchi Y, Wilson CJ, Augood SJ, Emson PC (1995) Striatal interneurones: chemical, physiological and morphological characterization. Trends Neurosci 18:527-535
12. 3H]-ACh release. J Neurochem 62:960-966
13. Klockgether T, Turski L (1990) NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats. Ann Neurol 28:539-546
14. 2A receptor-mediated modulation of striatal acetylcholine release in vivo. J Neurochem 66:1882-1888
15. 2A antagonists in experimental models. Adv Neurol 80 (in press)
16. Mally J, Stone TW (1994) The effect of theophylline on parkinsonian symptoms. J Pharm Pharmacol 46:515-517
17. 2A receptor antagonists in the treatment of movement disorder. CNS Drugs 10:311-320
18. 2 receptors modulate haloperidol-induced catalepsy in rats. Eur J Pharmacol 328:135-141
19. Marsden CD, Parkes JD, Quinn N (1982) Fluctuations in disability in Parkinson's disease: clinical aspects. In: Marsden CD, Fahn S (eds) Movement disorders. Butterworth Scientific, New York, pp 96-122
20. Menzaghi F, Whelan K, Risbrough VB, Rao TS, Lloyd GK (1997) Interactions between a novel cholinergic ion channel agonist, SIB-1765F and L-DOPA in the reserpine model of Parkinson's disease in rats. J Pharmacol Exp Ther 280:393-401
21. 2A receptors in regulating GABAergic synaptic transmission in striatal medium spiny neurons. J Neurosci 16:605-611
22. 2 receptor antagonist. Eur J Pharmacol 267:335-341
23. 2 receptor antagonist, to rat brain membranes. Mol Pharmacol 46:817-822
24. 2A receptor antagonists as new agents for the treatment of Parkinson's disease. Trends Pharmacol Sci 18:338-344
25. Schiffmann SN, Vanderhaeghen JJ (1993) Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons. J Neurosci 13:1080-1087
26. 1 dopamine receptor. Brain Res 519:333-337
27. 2 antagonists. J Med Chem 35:2342-2345
28. 2A antagonists with potent anti-cataleptic activity. Bioorg Med Chem Lett 18:2349-2352
29. Skuza G, Rogoz Z, Quack G, Danysz W (1994) Memantine, amantadine, and L-deprenyl potentiate the action of L-DOPA in monoamine-depleted rats. J Neural Transm [Gen Sect] 98:57-67
30. Sundstrom E, Fredriksson A, Archer T (1990) Chronic neurochemical and behavioral changes in MPTP-lesioned C57BL/6 mice: a model for Parkinson's disease. Brain Res 528:181-188
31. Sundstrom E, Henriksson BG, Mohammed AH, Souverbie F (1994) MPTP-treated mice: a useful model for Parkinson's disease? In: Woodruff ML, Nonneman AJ (eds) Toxin-induced models of neurological disorders. Plenum Press, New York, pp 121-137
32. Zarrindast MR, Modabber M, Sabetkasai M (1993) Influences of different adenosine receptor subtypes on catalepsy in mice. Psychopharmacology 113:257-261
33. Zarrindast MR, Iraie F, Heidari MR, Mohagheghi-Badi M (1997) Effect of adenosine receptor agonists and antagonists on morphine-induced catalepsy in mice. Eur J Pharmacol 338:11-16
34. 2A adenosine receptor antagonist. J Pharmacol Exp Ther 276:398-404