Antagonism of adenosine A(2A) receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens

Neuroscience

Volumn 79, Issue 3, 1997, Pages 753-764

  Svenningsson, P ^a   Nomikos, G G ^a   Ongini, E ^b   Fredholm, B B ^a  

^a Sect Molec Neuropharmacology   (Sweden)

^b Schering Plough Research Institute   (Italy)

Author keywords

Adenosine receptors; Cortex; Immediate early genes; Motor behaviour; Striatum; Xanthines

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A2A RECEPTOR; CAFFEINE; MESSENGER RNA; NERVE GROWTH FACTOR; ADENOSINE RECEPTOR; DNA BINDING PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; EGR1 PROTEIN, RAT; IMMEDIATE EARLY PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AROUSAL; ARTICLE; AUTORADIOGRAPHY; BEHAVIOR; BRAIN CORTEX; CAUDATE NUCLEUS; CONTROLLED STUDY; IMMEDIATE EARLY GENE; IN SITU HYBRIDIZATION; LOCOMOTION; MALE; MOTOR ACTIVITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PUTAMEN; RAT; REARING; ANIMAL; DRUG EFFECT; METABOLISM; RADIOASSAY; SPRAGUE DAWLEY RAT;

ANIMALS; CAFFEINE; CAUDATE NUCLEUS; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; IMMEDIATE-EARLY PROTEINS; IN SITU HYBRIDIZATION; LOCOMOTION; MALE; NUCLEUS ACCUMBENS; PUTAMEN; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0030610486     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00046-8     Document Type: Article

References (58)

1. Alexander S. P., Reddington M. The cellular localization of adenosine receptors in rat striatum. Neuroscience. 28:1989;645-651.
2. 2a receptor mRNA is expressed by enkephalin cells but not by somatostatin cells in rat striatum: a co-expression study. Molec. Brain Res. 22:1994;204-210.
3. Ballarin M., Herrera-Marschitz M., Casas M., Ungerstedt U. Striatal adenosine levels measured in vivo by microdialysis in rats with unilateral dopamine denervation. Neurosci. Lett. 83:1987;338-344.
4. 2a receptors in the nucleus accumbens. Prog. Neuropsychopharmac. biol. Psychiat. 18:1994;545-553.
5. 2A adenosine receptors on sleep-waking patterns in rats. Drug Dev. Res. 37:1996;65-72.
6. 1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes. Naunyn-Schmiedeberg's Arch. Pharmac. 335:1987;59-63.
7. Castro C. A., Hogan J. B., Benson K. A., Shehata C. W., Landauer M. R. Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620. Pharmac. Biochem. Behav. 50:1995;521-526.
8. 2A receptors. Naunyn-Schmiedeberg's Arch. Pharmac. 353:1996;261-271.
9. 2a receptors in the rat hippocampus. Brain Res. 649:1994;208-216.
10. Daly J. W. (1993) Mechanism of action of caffeine. In Caffeine, Coffee, and Health (ed. Garattini S.), pp. 97-150. Raven Press, New York.
11. Dixon A. K., Gubitz A. K., Sirinathsinghji D. J. S., Richardson P. J., Freeman T. C. Tissue distribution of adenosine receptor mRNAs in the rat. Br. J. Pharmac. 118:1996;1461-1468.
12. Ericson E., Samuelsson J., Ahlenius S. Photocell measurements of rat motor activity. J. pharmac. Meth. 25:1991;111-122.
13. 1-receptors and 5′-nucleotidase in the brain of some commonly used experimental animals. Neuroscience. 22:1987;813-826.
14. Ferré S., Fuxe K., von Euler G., Johansson B., Fredholm B. B. Adenosine-dopamine interactions in the brain. Neuroscience. 51:1992;501-512.
15. 2 dopamine receptors in rat striatum. Molec. Brain Res. 14:1992;186-195.
16. Fredholm B. B. Are methylxanthine effects due to antagonism of endogenous adenosine? Trends pharmac. Sci. 1:1980;129-132.
17. Fredholm B. B. Adenosine, adenosine receptors and the actions of caffeine. Pharmac. Toxicol. 76:1995;93-101.
18. Fredholm B. B., Abbracchio M. P., Burnstock G., Daly J. W., Harden T. K., Jacobson K. A., Leff P., Williams M. Nomenclature and classification of purinoceptors. Pharmac. Rev. 46:1994;143-156.
19. Fredholm B. B., Dunwiddie T. V. How does adenosine inhibit transmitter release? Trends pharmac. Sci. 9:1988;130-134.
20. Fredholm B. B., Herrera-Marschitz M., Jonzon B., Lindström K., Ungerstedt U. On the mechanism by which methylxanthines enhance apomorphine-induced rotation behaviour in the rat. Pharmac. Biochem. Behav. 19:1983;535-541.
21. Garrett B. E., Holtzman S. G. Does adenosine receptor blockade mediate caffeine-induced rotational behavior? J. Pharmac. exp. Ther. 274:1995;207-214.
22. 2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science. 250:1990;1429-1432.
23. 3H]-cyclohexyladenosine. J. Neurosci. 2:1982;1230-1241.
24. 1-selective antagonist, DPCPX. Psychopharmacology. 103:1991;541-544.
25. Holtzman S. G. CGS 15943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant rats. Life Sci. 49:1991;1563-1570.
26. 2-adenosine antagonist in vitro and in vivo. Fedn Eur. biochem. Socs Lett. 323:1993;141-144.
27. Jiang H., Jackson-Lewis V., Muthane U., Dollison A., Ferreira M., Espinosa A., Parsons B., Przedborski S. Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats. Brain Res. 613:1993;347-351.
28. 2 adenosine receptor binding and on mRNA levels. Naunyn-Schmiedeberg's Arch. Pharmac. 347:1993;407-414.
29. Johansson B., Herrera-Marschitz M., Svenningsson P., Fredholm B. B. Caffeine-induced expression of the proto-oncogene c-fos in rat striatum is increased after dopamine denervation. Acta physiol. scand. 149:1993;527-529.
30. Johansson B., Lindström K., Fredholm B. B. Differences in the regional and cellular localization of c-fos mRNA induced by amphetamine, cocaine and caffeine in the rat. Neuroscience. 59:1994;837-849.
31. Le Moine C., Normand E., Guitteny A. F., Fouque B., Teoule R., Bloch B. Dopamine receptor gene expression by enkephalin neurons in rat forebrain. Proc. natn. Acad. Sci. U.S.A. 87:1990;230-234.
32. 1 adenosine receptor from rat brain. Molec. Pharmac. 40:1991;1-7.
33. 2 receptors: selective localization in the human basal ganglia and alterations with disease. Neuroscience. 42:1991;697-706.
34. Milbrandt J. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science. 238:1987;797-799.
35. Milbrandt J. Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron. 1:1988;183-188.
36. Moratalla R., Robertson H. A., Graybiel A. M. Dynamic regulation of NGFI-A (zif268, egr1) gene expression in the striatum. J. Neurosci. 12:1992;2609-2622.
37. Morgan J. I., Curran T. Proto-oncogene transcription factors and epilepsy. Trends pharmac. Sci. 12:1991;343-349.
38. Nakajima T., Daval J. L., Morgan P. F., Post R. M., Marangos P. J. Adenosinergic modulation of caffeine-induced c-fos mRNA expression in mouse brain. Brain Res. 501:1989;307-314.
39. 3H]-CGS 21680 as a ligand. Naunyn-Schmiedeberg's Arch. Pharmac. 342:1990;85-89.
40. Paxinos G. and Watson W. (1986) The Rat Brain in Stereotaxic Coordinates, 2nd edn. Academic Press, London.
41. 2A adenosine receptors positively modulates turning behaviour and c-fos expression induced by D-1 agonists in dopamine-denervated rats. Eur. J. Neurosci. 8:1996;1176-1181.
42. Pontieri F. E., Tanda G., Di Chiara G. Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proc. natn. Acad. Sci. U.S.A. 92:1995;12304-12308.
43. Pontieri F. E., Tanda G., Orzi F., Di Chiara G. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature. 382:1996;255-257.
44. 1 receptors prevents the EEG arousal due to dopamine D-1 receptor activation in rabbits. Eur. J. Pharmac. 305:1996;123-126.
45. Rainnie D. G., Grunze H. C., McCarley R. W., Greene R. W. Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal [published erratum appears in Science 1994 Jul 1; 265(5168):16]. Science. 263:1994;689-692.
46. 1-adenosine receptor that is widely expressed in brain and spinal cord. Molec. Endocrinol. 5:1991;1037-1048.
47. 2 in rats. Proc. natn. Acad. Sci. U.S.A. 93:1996;5980-5984.
48. 2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study. J. Neurochem. 57:1991;1062-1067.
49. 2 receptors regulate the gene expression of striatopallidal and striatonigral neurons. J. Neurosci. 13:1993;1080-1087.
50. 2-like dopamine receptor agonists. Science. 271:1996;1586-1589.
51. Sheng M., Greenberg M. E. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron. 4:1990;477-485.
52. Snyder S. H., Katims J. J., Annau Z., Bruns R. F., Daly J. W. Adenosine receptors and behavioral actions of methylxanthines. Proc. natn. Acad. Sci. U.S.A. 78:1981;3260-3264.
53. Svenningsson P., Johansson B., Fredholm B. B. Caffeine-induced expression of c-fos mRNA and NGFI-A mRNA in caudate-putamen and in nucleus accumbens are differentially affected by the N-methyl-D-aspartate receptor antagonist MK-801. Molec. Brain Res. 35:1996;183-189.
54. Svenningsson P., Nomikos G. G., Fredholm B. B. Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration. J. Neurosci. 15:1995;7612-7624.
55. Svenningsson P., Ström A., Johansson B., Fredholm B. B. Increased expression of c-jun, junB, AP-1 and preproenkephalin mRNA in rat striatum following a single injection of caffeine. J. Neurosci. 15:1995;3583-3593.
56. Wisden W., Errington M. L., Williams S., Dunnitt S. B., Waters C., Hitchcock D., Evan G., Bliss T. V. P., Hunt S. P. Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron. 4:1990;603-614.
57. Worley C. M., Valadez A., Schenk S. Reinstatement of extinguished cocaine-taking behavior by cocaine and caffeine. Pharmac. Biochem. Behav. 48:1994;217-221.
58. 2A adenosine receptor antagonist. J. Pharmac. exp. Ther. 276:1996;398-404.