Forebrain induction, retinoic acid, and vulnerability to schizophrenia: insights from molecular and genetic analysis in developing mice

Biological Psychiatry

Volumn 46, Issue 1, 1999, Pages 19-30

  Lamantia, Anthony Samuel ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Forebrain; Induction; Neurodevelopment; Retinoic acid; Schizophrenia

Indexed keywords

RETINOIC ACID;

FOREBRAIN; HUMAN; NERVE CELL DIFFERENTIATION; OLFACTORY EPITHELIUM; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA;

ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; MICE; MICE, INBRED STRAINS; PHENOTYPE; POINT MUTATION; PROSENCEPHALON; SCHIZOPHRENIA; TRETINOIN;

EID: 0033035664     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00002-5     Document Type: Review

References (100)

1. Akbarian S., Kim J.J., Potkin S.G., et al. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry. 52:1995;258-266.
2. Anchan R.M., Drake D.P., Gerwe E.A., Haines C.F., LaMantia A.-S. A failure of retinoid-mediated induction accompanies the loss of the olfactory pathway during mammalian forebrain development. J Comp Neurol. 379:1997;1-15.
3. Anchan R.M., Thomas M.B., LaMantia A.S. A genetic analysis of the role of neural crest derived fronto-nasal mesenchyme in olfactory pathway induction. Soc Neurosci Abstr. 23:1997;6.
4. Anderson S.A., Eisenstat D.D., Shi L., Rubenstein J.L.R. Interneuron migration from the basal forebrain to neocortex Dependence on Dlx genes . Science. 278:1997;474-476.
5. Anderson S.A., Qui M.S., Bulfone A., et al. Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons. Neuron. 19:1997;27-37.
6. Balkan W., Colbert M.C., Bock C., Linney E. Transgenic indicator mice for studying activated retinoic acid receptors during development. Proc Natl Acad Sci USA. 89:1992;3347-3351.
7. Balkan W., Klintworth G.K., Bock C.B., Linney E. Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects. Dev Biol. 151:1992;622-625.
8. Bronner-Fraser M. Patterning the vertebrate neural crest. Perspect Dev Neurobiol. 3:1995;53-62.
9. Bryant S.V., Gardiner D.M. Retinoic acid, local cell-cell interactions, and pattern formation in vertebrate limbs. Dev Biol. 152:1992;1-25.
10. Bullmore E.T., Frangou S., Murray R.M. The dysplastic net hypothesis An integration of developmental and disconnection theories of schizophrenia . Schizophr Res. 28:1997;143-156.
11. Byrd C.A., Burd G.D. Development of the olfactory bulb in the clawed frog, Xenopus laevis A morphological and quantitative analysis . J Comp Neurol. 314:1991;79-90.
12. Carlson C., Papolos D., Pandita R.K., et al. Molecular analysis of Velo-Cardio-Facial Syndrome patients with psychiatric disorders. Am J Hum Genet. 60:1997;851-859.
13. Cash D.E., Bock C.B., Schughart K., Linney E., Underhill T.M. Retinoic acid receptor alpha function in vertebrate limb skeletogenesis A modulator of chondrogenesis . J Cell Biol. 136:1997;445-457.
14. Chiang C., Litingtung Y., Lee E., et al. Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature. 383:1996;407-413.
15. Chambon P. The retinoid signaling pathway Molecular and genetic analyses . Semin Cell Biol. 5:1994;115-125.
16. Cohn M.J., Tickle C. Limbs A model for pattern formation within the vertebrate body plan . Trends Genet. 12:1996;253-257.
17. Colbert M.C., Linney E., LaMantia A.-S. Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development. Proc Natl Acad Sci USA. 90:1993;657-661.
18. Crossley P.H., Martin G.R. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development. 121:1995;439-451.
19. Chow E.W.C., Basset A.S., Weeksberg W. Velo-cardio-facial syndrome and psychotic disorders Implications for psychiatric genetics . Am J Med Genet. 54:1994;107-112.
20. Davis L.A., Sadler T.W. Effects of vitamin A on endocardial cushion development in the mouse heart. Teratology. 24:1981;139-148.
21. Driscoll D.A., Emanuel B.S. DiGeorge and velocardiofacial syndromes The 22q11 deletion syndrome . Ment Ret Dev Disabil Res Rev. 2:1996;130-138.
22. Duband J.-L., Monier F., Delannet M., Newgreen D. Epithelium-mesenchyme transition during neural crest development. Acta Anat. 154:1995;63-78.
23. Easter S.S. Jr, Ross L.S., Frankfurter A. Initial tract formation in the mouse brain. J Neurosci. 13:1993;285-299.
24. Echelard Y., Epstein D.J., St-Jacques B., et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 75:1993;1417-1430.
25. Friedrich G., Soriano P. Promoter traps in embryonic stem cells A genetic screen to identify and mutate developmental genes in mice . Genes Dev. 5:1991;1513-1523.
26. Furuta Y., Piston D.W., Hogan B.L. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. 124:1997;2203-2212.
27. Ghyselinck N.B., Wendling O., Messaddeq N., et al. Contribution of retinoic acid receptor beta isoforms to the formation of the conotruncal septum of the embryonic heart. Dev Biol. 198:1998;303-318.
28. Giguere V. Retinoic acid receptors and cellular retinoid binding proteins Complex interplay in retinoid signaling . Endocr Rev. 15:1994;61-79.
29. Goldberg R., Motzkin B., Marion R., Scambler P.J., Shprintzen R.J. Velo-cardio-facial syndrome A review of 120 patients . Am J Med Genet. 45:1993;313-319.
30. Golding-Kushner K.J., Weller G., Shprintzen P.J. Velo-cardio-facial syndrome Language and psychological profiles . J Craniofac Genet Dev Biol. 5:1985;259-266.
31. Goldman-Rakic P.S., Selemon L.D. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr Bull. 23:1997;437-458.
32. Goodman A.B. Three independent lines of evidence suggest retinoids as causal to schizophrenia. Proc Natl Acad Sci USA. 95:1998;7240-7244.
33. Goodman A.B. Chromosomal locations and modes of action of genes of the retinoid (Vitamin A) system support their involvement in the etiology of schizophrenia. Am J Med Genet. 60:1995;335-348.
34. Goodman A.B. Retinoid disregulation may result in abnormal expression of glutamic acid decarboxylase in schizophrenia. Arch Gen Psych. 53:1995;653.
35. Goodman A.B. Congenital anomalies in relatives of schizophrenic probands may indicate a retinoid pathology. Schizophr Res. 19:1996;163-170.
36. Gothelf D., Frisch A., Munitz H., et al. Velocardiofacial manifestations and microdeletions in schizophrenic inpatients. Am J Med Genet. 72:1997;455-461.
37. Gotz M., Wizenmann A., Reinhardt S., Lumsden A., Price J. Selective adhesion of cells from different telencephalic regions. Neuron. 16:1996;551-564.
38. Glass C.K., Rose D.W., Rosenfeld M.G. Nuclear receptor coactivators. Current Opin Cell Biol. 9:1997;222-232.
39. Green M.F., Satz P., Gaier D.J., Ganzell S., Kharabi F. Minor physical anomalies in schizophrenia. Schizophr Bull. 151:1989;91-99.
40. Gualtieri C.T., Adams A., Shen C.D., Loiselle D. Minor physical anomalies in alcoholic and schizophrenic adults and hyperactive and autistic children. Am J Psychiatry. 139:1982;640-643.
41. Gurdon J.B. Embryonic induction - molecular perspectives. Development. 99:1987;285-306.
42. Guy J.D., Majorksi L.V., Wallace J.J., Guy M.P. The incidence of minor physical anomalies in adult male schizophrenics. Schizophr Bull. 9:1983;571-582.
43. Hamburger V. The Heritage of Experimental Embryology - Hans Spemann and the Organizer. 1988;Oxford University Press, New York.
44. Heckers S. Neuropathology of schizophrenia Cortex, thalamus, basal ganglia, and neurotransmitter-specific projection systems . Schizophr Bull. 23:1997;403-421.
45. Helms J.A., Kim C.H., Hu D., Minkoff R., Thaller C., Eichele G. Sonic hedgehog participates in craniofacial morphogenesis and is down-regulated by teratogenic doses of retinoic acid. Dev Biol. 187:1997;25-35.
46. Hill R.E., Favor J., Hogan B.L.M., et al. Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature. 354:1991;522-525.
47. Sey-Neu) A mouse model for the genetic analysis of craniofacial abnormalities . Development. 103:(suppl):1988;115-119.
48. Hogan B.L.M. Bone morphogenetic proteins Multifunctional regulators of vertebrate development . Genes Dev. 10:1996;1580-1594.
49. Jessell T.M., Melton D.A. Diffusible factors in vertebrate embryonic induction. Cell. 68:1992;257-260.
50. Johnson D.R. Extra toes A new mutant gene causing multiple abnormalities in the mouse . J Embryol Exp Morph. 17:1967;543-581.
51. Johnson R.L., Tabin C.J. Molecular models for vertebrate limb development. Cell. 90:1997;979-990.
52. Jones E.G. Cortical development and thalamic pathology in schizophrenia. Schizophr Bull. 23:1997;483-501.
53. Karayiorgou M., Morris M.A., Morrow B., et al. Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc Natl Acad Sci USA. 92:1995;7612-7616.
54. Krezel W., Ghyselinck N., Samad T.A., et al. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science. 279:1998;863-867.
55. Kwasigroch T.E., Kochhar D.M. Production of congenital limb defects with retinoic acid Phenomenological evidence of progressive differentiation during limb morphogenesis . Anat Embryol. 161:1980;105-113.
56. LaMantia A.-S., Colbert M.C., Linney E. Induction and the generation of regional and cellular diversity in the developing mammalian brain. Neural Cell Specification Third Annual Altschul Symposium Proceedings . 1995;51-65 Plenum Press, New York.
57. LaMantia A.-S., Colbert M.C., Linney E. Retinoic acid induction and regional differentiation prefigure olfactory pathway formation in the mammalian forebrain. Neuron. 10:1993;1035-1048.
58. Lammer E.J., Chen D.T., Hoar R.M., et al. Retinoic acid embryopathy. New Engl J Med. 313:1985;837-841.
59. Le Dourain N.M., Dupin E., Ziller C. Genetic and epigenetic control in neural crest development. Curr Opin Genet Dev. 4:1994;685-695.
60. Linney E., LaMantia A.-S. Retinoid signalling in mouse embryos. Adv Dev Biol. 3:1994;73-114.
61. Lumsden A.G.S. Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ. Development. 103:1988;155-169.
62. Lumsden A., Krumlauf R. Patterning the vertebrate neuraxis. Science. 274:1997;1109-1115.
63. Mangelsdorf D.J., Evans R.M. The RXR heterodimers and orphan receptors. Cell. 83:1995;841-850.
64. Napoli J.L., Boerman M.H., Chai X., Zhai Y., Fiorella P.D. Enzymes and binding proteins affecting retinoic acid concentrations. J Steroid Biochem Mol Biol. 53:1995;497-502.
65. O'Callaghan E., Buckley P., Madigan C., et al. The relationship of minor physical anomalies and other putative indices of developmental disturbance in schizophrenia to abnormalities of cerebral structure on magnetic resonance imaging. Biol Psychiatry. 38:1995;516-524.
66. O'Callaghan E., Larkin C., Kinsella A., Waddington J.L. Familial, obstetric and other clinical correlates of minor physical anomalies in schizophrenia. Am J Psychiatry. 148:1991;479-483.
67. Osumi-Yamashita N., Ninomiya Y., Doi H., Eto K. The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos. Dev Biol. 164:1994;409-419.
68. Papolos D.F., Faedda G.L., Veit S., et al. Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome Does a hemizygous deletions of chromosome 22q11 result in bipolar affective disorder? Am J Psychiatry. 153:1996;1541-1547.
69. Pike A.S., Super M. Velocardiofacial syndrome. Postgrad Med J. 73:1997;771-775.
70. Pulver A.E., Karayiorgiou M., Wolyniec P.S., et al. Sequential strategy to identity a susceptibility gene for schizophrenia Report of a potential linkage on chromosome 22q12-13.1: Part 1 . Am J Med Genet. 54:1994;36-43.
71. Quinn J.C., West J.D., Kaufman M.H. Genetic background effects on dental and other craniofacial abnormalities in homozygous small eye (Pax6-Sey/Pax6-Sey) mice. Anat Embryol. 196:1997;311-321.
72. Rajkowska G., Selemon L.D., Goldman-Rakic P.S. Neuronal and glial somal size in the prefrontal cortex. A postmortem morphometric study of schizophrenia and Huntington disease. Arch Gen Psychiatry. 55:1998;215-224.
73. Rothman K.J., Moore L.L., Singer M.R., Nguyen U-SDT, Mannino S., Milunsky A. Teratogenicity of high vitamin A intake. N Engl J Med. 333:1995;1369-1373.
74. Rubenstein J.L.R., Beachy P.A. Patterning of the embryonic forebrain. Curr Opin Neurobiol. 8:1998;18-26.
75. Rubenstein J.L.R., Martinez S., Shimamura K., Puelles L. The prosomeric model A proposal for the organization of the embryonic forebrain . Science. 266:1994;578-580.
76. Rubenstein J.L.R., Shimamura K., Martinez S., Puelles L. Regionalization of the prosencephalic neural plate. Ann Rev Neurosci. 21:1998;445-477.
77. Ryan A.K., Goodship J.A., Wilson D.I., et al. Spectrum of clinical features associated with interstitial chromosome 22q11 deletions A European collaborative study . J Med Genet. 34:1997;798-804.
78. Schimmang T., Lemaistre M., Vortkamp A., Ruther U. Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development. 116:1992;799-804.
79. Schmahl W., Knoedlseder M., Favor J., Davidson D. Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6 locus. Acta Neuropath. 86:1993;126-135.
80. Selemon L.D., Rajkowska G., Goldman-Rakic P.S. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients Application of a three-dimensional, stereologic counting method . J Comp Neurol. 392:1998;402-412.
81. Selemon L.D., Rajkowska G., Goldman-Rakic P.S. Abnormally high neuronal density in two widespread areas of the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17. Arch Gen Psychiatry. 52:1995;805-818.
82. Serbedzija G.N., Bronner-Fraser M., Fraser S.E. Vital dye analysis of cranial neural crest cell migration in the mouse embryo. Development. 116:1992;297-307.
83. Shenefelt R.E. Morphogenesis of malformations in hamsters caused by retinoic acid Relations to dose and stage at treatment . Teratology. 5:1972;104-118.
84. Slack J.M. Embryonic induction. Mech Dev. 41:1993;91-107.
85. Sockanathan S., Jessell T.M. Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell. 94:1998;503-514.
86. Stout R.P., Graziadei P.P.C. Influence of the olfactory placode on the development of the brain in Xenopus Laevis (Daudin). I. Axonal growth and connections of the transplanted olfactory placode. Neuroscience. 5:1980;2175-2186.
87. Stoykova A., Goetz M., Gruss P., Price J. Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain. Development. 124:1997;3765-3777.
88. Sulik K.K., Cook C.S., Webster W.S. Teratogens and craniofacial malformations Relationships to cell death . Development. 103:(suppl):1988;213-232.
89. Sullivan S.L., Bohm S., Ressler K.J., Horowitz L.F., Buck L.B. Target-independent pattern specification in the olfactory epithelium. Neuron. 15:1995;779-789.
90. Tabin C.J. The initiation of the limb bud growth factors, Hox genes, and retinoids . Cell. 60:1995;671-674.
91. Tanabe Y., Jessell T.M. Diversity and pattern in the developing spinal cord. Science. 274:1996;1115-1123.
92. Thomas M.B., Anchan R.M., Bodemer W.S., Mann S., LaMantia A.-S. The neural crest contributes to populations of inductive mesenchyme in the developing mouse. Soc Neuroscience Abstr. 23:1997;6.
93. Tickle C., Eichele G. Vertebrate limb development. Ann Rev Cell Biol. 10:1994;121-152.
94. Waddington J.L. Schizophrenia Developmental neuroscience and pathobiology . Lancet. 341:1993;531-536.
95. Warren N., Price D.J. Roles of Pax-6 in murine diencephalic development. Development. 124:1997;1573-1582.
96. Webster W.S., Johnson M.C., Lammer E.J., Sulik K.K. Isotretinoin embryopathy and the cranial neural crest An in vivo and in vitro study . J Craniofac Genet Dev Biol. 6:1986;211-222.
97. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry. 44:1987;660-669.
98. West J.R., Chen W.-J.A., Pantazis N.J. Fetal alcohol syndrome The vulnerability of the developing brain and possible mechanisms of damage . Metab Brain Dis. 9:1994;291-322.
99. Whitesides J.G., Hall M.E., Anchan R.M., LaMantia A.-S. Retinoid signaling distinguishes a subpopulation of olfactory receptor neurons in the developing and adult mouse. J Comp Neurol. 394:1998;445-461.
100. Whitesides J.G., LaMantia A.-S. Differential adhesion of neurons and neural precursor cells from a distinct domain in the developing mammalian forebrain. Dev Biol. 169:1995;229-241.