The nature of cryptic epitopes within the self-antigen myelin basic protein

International Immunology

Volumn 8, Issue 7, 1996, Pages 1035-1043

  Fairchild, Paul J ^a,b   Pope, Heather ^a   Wraith, David C ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Autoimmune; Encephalomyelitis; Lymphocyte; Peptide; Tolerance

Indexed keywords

EPITOPE; H2 ANTIGEN; MYELIN BASIC PROTEIN; PEPTIDE;

ALLERGIC ENCEPHALOMYELITIS; AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; HAPLOTYPE; IMMUNE SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; B-LYMPHOCYTES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES; HYBRIDOMAS; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; T-LYMPHOCYTES;

EID: 0030057418     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.7.1035     Document Type: Article

References (25)

1. Sercarz, E. E., Lehmann, P. V., Ametani, A., Benichou, G., Miller, A. and Moudgil, K. 1993. Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol. 11:729
2. Rothbard, J. B. and Gefter, M. L. 1991. Interactions between immunogenic peptides and MHC proteins, Annu. Rev. Immunol. 9:527.
3. Lanzavecchia, A., Reid, P. A. and Watts, C. 1992. Irreversible association of peptides with class II MHC molecules in living cells. Nature 357:249.
4. Fairchild, P J., Wildgoose, R., Atherton, E., Webb S. and Wraith, D. C. 1993. An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction. Int. Immunol. 5:1151.
5. k form and dissociate rapidly at neutral pH. J. Immunol. 154:5216,
6. Liu, G. Y., Fairchild, P. J., Smith, R. M., Prowle, J. R., Kioussis, D. and Wraith, D. C. 1995. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3:407.
7. Joosten, I., Wauben, M. H. M., Holewijn, M. C., Reske, K., Pedersen, F. L., Roosenboom, C. F. P., Hensen, E. J., van Eden, W. and Buus, S. 1994. Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class II molecules. Int. Immunol. 6:751.
8. Abromson-Leeman, S., Alexander, J., Bronson, R., Carroll, J., Southwood, S. and Dorf, M. 1995. Experimental autoimmune encephalomyelitis-resistant mice have highly encephalitogenic myelin basic protein (MBP)-specific T cell clones that recognize a MBP peptide with high affinity for MHC class II. J. Immunol. 154:388.
9. Wall, M., Southwood, S., Sidney, S., Oseroff, C., del Guericio, M. F., Lamont, A. G., Colon, S. M., Arrhenius, T., Gaeata, F. C. A. and Sette, A. 1992. High affinity for class II molecules as a necessary but not sufficient characteristic of encephalitogenic determinants. Int. Immunol. 4:773.
10. Wraith, D. C., Smilek, D. E. and Webb, S. 1992. MHC-binding peptides for immunotherapy of experimental autoimmune disease. J. Autoimmun. 5 (Suppl. A):103.
11. Wraith, D. C., Smilek, D. E., Mitchell, D. J., Steinman, L. and McDevitt, H. O. 1989. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 59:247.
12. Wraith, D. C., Bruun, B. and Fairchild, P. J. 1992. Cross-reactive antigen recognition by an encephalitogenic T cell receptor. J. Immunol. 149:3765.
13. Watson, J. 1979. Continuous proliferation of murine antigen specific helper T lymphocytes in culture. J. Exp. Med. 150:1510.
14. Srinivasan, M., Domanico, S. Z., Kaumaya, P. T. P. and Pierce, S. K. 1993. Peptides of 23 residues or greater are required to stimulate a high affinity class II-restricted response. Eur. J. Immunol. 23:1011
15. Gautam, A. M., Pearson, C. J., Smilek, D. E., Steinman, L. and McDevitt, H. O. 1992. A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis. J. Exp. Med. 176:605.
16. Lanzavecchia, A. 1995. How can cryptic epitopes trigger autoimmunity? J. Exp. Med. 181:1945.
17. Fairchild, P. J., Thorpe, C. J., Travers, P. J. and Wraith, D. C. 1994. Modulation of the immune response with T-cell epitopes: the ultimate goal for specific immunotherapy of autoimmune disease. Immunology 81:487.
18. Fritz, R. B., Skeen, M. J., Chou, C. H. J. and McFarlin, D. E. 1985. Major histocompatibility complex linked control of the immune response to myelin basic protein. J. Immunol. 134:2328.
19. Zamvil, S. S., Mitchell, D. J., Moore, A. C., Kitamura, K., Steinman, L. and Rothbard, J. B. 1986. T cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324:258.
20. k-restricted determinant of hen egg lysozyme: limitations of lymph node proliferation studies in defining immunodominance and crypticity. Proc. Natl Acad. Sci. USA 92:2214.
21. Simitsek, P. D., Campbell, D. G., Lanzavecchia, A., Fairweather, N. and Watts, C. 1995. Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T determinants. J. Exp. Med. 181:1957.
22. Lipham, W. J., Redmond, T. M., Takahashi, H., Berzofsky, J. A., Wiggert, B., Chader, G. J. and Gery, I. 1991. Recognition of peptides that are immunopathogenic but cryptic. J. Immunol. 146:3757.
23. Balasa, B. and Carayanniotis, G. 1993. Induction of experimental autoimmune thyroiditis in rats with the synthetic peptide (2495-2511) of thyroglobulin. Cell. Immunol. 148:259.
24. Bockenstedt, L. K., Gee, R. J. and Mamula, M. J. 1995. Self-peptides in the initiation of lupus autoimmunity. J. Immunol. 154:3516.
25. Hammer, J., Gallazzi, F., Bono, E., Karr, R. W., Guenot, J., Valsasnini, P., Nagy, Z. A. and Sinigaglia, F. 1995. Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association. J. Exp. Med. 181:1847.