Immunodominance among EBV-derived epitopes restricted by HLA-B27 does not correlate with epitope abundance in EBV-transformed B-lymphoblastoid cell lines

Journal of Immunology

Volumn 164, Issue 12, 2000, Pages 6120-6129

  Crotzer, Victoria L ^a   Christian, Robert E ^b   Brooks, Jill M ^c   Shabanowitz, Jeffrey ^b   Settlage, Robert E ^b   Marto, Jarrod A ^b   White, Forest M ^b   Rickinson, Alan B ^c   Hunt, Donald F ^a,b   Engelhard, Victor H ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN; HLA B27 ANTIGEN;

AMINO ACID SEQUENCE; ARTICLE; B LYMPHOBLAST; EPITOPE MAPPING; EPSTEIN BARR VIRUS; IMMUNOGENICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL;

EID: 0034660192     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.12.6120     Document Type: Article

References (49)

1. Rickinson, A. B., and E. Kieff. 1996. Epstein-Barr virus. In Field's Virology. B. N. Fields, D. M. Knipe, and P. M. Howley, eds. Lippincott-Raven, Philadelphia, p. 2397.
2. Sixbey, J. W., J. G. Nedrud, N. Raab-Traub, R. A. Hanes, and J. S. Pagano. 1984. Epstein-Barr virus replication in oropharyngeal epithelial cells. N. Engl. J. Med. 310:1225.
3. Tierney, R. J., N. Steven, L. S. Young, and A. B. Rickinson. 1994. Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state. J. Virol. 68:7374.
4. Yao, Q. Y., R. J. Tierney, D. Croom-Carter, D. Dukers, G. M. Cooper, C. J. Ellis, M. Rowe, and A. B. Rickinson. 1996. Frequency of multiple Epstein-Barr virus infections in T-cell-immunocompromised individuals. J. Virol. 70:4884.
5. Wallace, L. E., A. B. Rickinson, M. Rowe, and M. A. Epstein. 1982. Epstein-Barr virus-specific cytotoxic T-cell clones restricted through a single HLA antigen. Nature 297:413.
6. Moss, D. J., I. S. Misko, S. R. Burrows, K. Burman, R. McCarthy, and T. B. Sculley. 1988. Cytotoxic T-cell clones discriminate between A- and B-type Epstein-Barr transformants. Nature 331:719.
7. Pamer, E., and P. Cresswell. 1998. Mechanisms of MHC class I-restricted antigen processing. Annu. Rev. Immunol. 16:323.
8. Rickinson, A. B., and D. J. Moss. 1997. Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection. Annu. Rev. Immunol. 15:405.
9. Brooks, J. M., R. A. Colbert, J. P. Mear, A. M. Leese, and A. B. Rickinson. 1998. HLA-B27 subtype polymorphism and CTL epitope choice: studies with EBV peptides link immunogenicity with stability of the B27:peptide complex. J. Immunol. 161:5252.
10. Brooks, J. M., D. Croom-Carter, A. M. Leese, R. J. Tierney, G. Habeshaw, and A. B. Rickinson. 2000. Cytotoxic T-lymphocyte responses to a polymorphic Epstein-Barr virus epitope identify healthy carriers with coresident viral strains. J. Virol. 74:1801.
11. Brooks, J. M., R. J. Murray, W. A. Thomas, M. G. Kurilla, and A. B. Rickinson. 1993. Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide. J. Exp. Med. 178:879.
12. Jardetzky, T. S., W. S. Lane, R. A. Robinson, D. R. Madden, and D. C. Wiley. 1991. Identification of self peptides bound to purified HLA-B27. Nature 353:326.
13. Rotzschke, O., K. Falk, S. Stevanovic, V. Gnau, G. Jung, and H. G. Rammensee. 1994. Dominant aromatic/aliphatic C-terminal anchor in HLA-B*2702 and B*2705 peptide motifs. Immunogenetics 39:74.
14. Galocha, B., J. R. Lamas, J. A. Villadangos, J. P. Albar, D. Lopez, and J. A. Castro. 1996. Binding of peptides naturally presented by HLA-B27 to the differentially disease-associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism. Tissue Antigens 48:509.
15. Lamas, J. R. J. M. Brooks, B. Galocha, A. B. Rickinson, D. Lopez and J. A. Castro. 1998 Relationship between peptide binding and T cell epitope selection: a study with subtypes of HLA-B27. Int. Immunol. 10:259.
16. Chen, Y., J. Sidney, S. Southwood, A. L. Cox, K. Sakaguchi, R. Henderson, E. Appela, D. F. Hunt, A. Sette, and V. H. Engelhard. 1994. Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations. J. Immunol. 152: 2874.
17. Skipper, J. C. A., R. C. Hendrickson, P. H. Gulden, V. Brichard, A. Van Pel, Y. Chen, J. Shabanowitz, T. Wolfel, C. L. Slingluff, T. Boon, et al. 1996. An HLA-A2 restricted tyrosinase antigen on melanoma cells results from post-translational modification and suggests a novel processing pathway for membrane proteins. J. Exp. Med. 183:527.
18. Meadows, L. R., W. Wang, J. M. den Haan, E. Blokland, C. Reinhardus, J. W. Drifthout, J. Shabanowitz, R. Pierce, A. Agulnik, C. E. Bishop, et al. 1997. The HLA-A*0201-restricted HY antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. Immunity 6:273.
19. Chen, W., J. W. Yewdell, R. L. Levine, and J. R. Bennink. 1999. Modification of cysteine residues in vitro and in vivo affects the immunogenicity and antigenicity of major histocompatibility complex class I-restricted viral determinants. J. Exp. Med. 189:1757.
20. Hunt, D. F., R. A. Henderson, J. Shabanowitz, K. Sakaguchi, H. Michel, N. Sevilir, A. Cox, E. Apella, and V. H. Engelhard. 1992. Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 255:1261.
21. Shabanowitz, J., R. E. Settlage, J. A. Marto, R. E. Christian, F. M. White, P. S. Russo, S. E. Martin, and D. F. Hunt. 1999. Sequencing the primordial soup. In Mass Spectrometry in Biology and Medicine, A. L. Burlingame, S. A. Carr, and M. A. Baldwin, eds. Humana Press, Towata, NJ.
22. + T cells specific for EBV in healthy virus carriers. J. Immunol. 162:1827.
23. Guan, S., and A. G. Marshall. 1996. Stored Waveform Inverse Fourier Transform (SWIFT) ion excitation in trapped-ion mass spectrometry: theory and applications. Int. J. Mass Spectrom. Ion Processes 157:158:5.
24. Beier, D. C., J.H. Cox, D. R. Vining, P. Cresswell, and V. H. Engelhard. 1994. Association of human class I MHC alleles with the adenovirus E3/19K protein. J. Immunol. 152:3862.
25. + T lymphocytes from human blood. Proc. Natl. Acad. Sci. USA 96:12013.
26. + CTL. Mol. Immunol. 31:1285.
27. Kageyama, S., T. J. Tsomides, Y. Sykulev, and H. N. Eisen. 1995 Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses. J. Immunol. 154:567.
28. + cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 92:11990.
29. + T cells can recognize unusual, rare, and unique processe peptide/MHC complexes. J. Immunol. 157:4464.
30. Mendoza, L., P. Paz, A. R. Zuberi, G. Christianson, D. C. Roopenian, and N. Shastri. 1997. Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex. Immunity 7:461.
31. Sykulev, Y., M. Joo, I. Vturina, T. J. Tsomides, and H. N. Eisen. 1996. Evidence that a single peptide-MHC complex or a target cell can elicit a cytolytic T cell response. Immunity 4:565.
32. Tsomides, T. J., A. Aldovini, R. P. Johnson, B. D. Walker, R. A. Young, and H. N. Eisen. 1994. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J. Exp. Med. 180:1283.
33. Restifo, N. P., I. Bacik, K. R. Irvine, J. W. Yewdell, B. J. McCabe, R. W. Anderson, L. C. Eisenlohr, S. A. Rosenberg, and J. R. Bennink. 1995. Antigen processing in vivo and the elicitation pf primary CTL responses. J. Immunol. 154:4414.
34. Anton, L. C., J. W. Yewdell, and J. R. Bennink. 1997. MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies. J. Immunol. 158:2535.
35. Gallimore, A., T. Dumrese, H. Hengartner, R. M. Zinkernagel, and H. G. Rammensee. 1998. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. J. Exp. Med. 187:1647.
36. Levitsky, V., Q. J. Zhang, J. Levitskaya, and M. G. Masucci. 1996. The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4. J. Exp. Med. 183: 915.
37. Van Els, C., C. A. Herberts, E. Van der Heeft, M. C. Poelen, J. Van Gaans-Van den Brink, A. Van der Kooi, P. Hoogerhout, G. ten Hove, H. Meiring and A. P. J. M. de Jong. 2000. A single naturally processed measles virus peptide fully dominates the HLA-A*0201 associated peptide display and is mutated at its anchor position in persistent viral strains. Eur. J. Immunol. In press.
38. Bullock, T. N. J., T. A. Colella, and V. H. Engelhard. 2000. The density of peptides displayed by dendritic cells affects immune responses to human tyrosinase and gp100 in HLA-A2 transgenic mice. J. Immunol. 164:2354.
39. Vijh, S., and E. G. Pamer. 1997. Immunodominant and subdominant CTL responses to Listeria monocytogenes infection. J. Immunol. 158:3366.
40. Pamer, E. G., A. J. Sijts, M. S. Villanueva, D. H. Busch, and S. Vijh. 1997. MHC class I antigen processing of Listeria monocytogenes protein: implications for dominant and subdominant CTL responses. Immunol. Rev 158:129.
41. + T cells. Eur J. Immunol. 23:3306.
42. Moskophidis, D., F. Lechner, H. Pircher, and R. M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. [Published erratum appears in 1993 Nature 364:262.] Nature 362:758.
43. + T cells upon acute versus persistent viral infection. Immunity 9:449.
44. Rehermann, B., P. Fowler, J. Sidney, J. Person, A. Redeker, M. Brown, B. Moss, A. Sette, and F. V. Chisari. 1995. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J. Exp. Med. 181:1047.
45. Rehermann, B., K. M. Chang, J. McHutchinson, R. Kokka, M. Houghton, C. M. Rice, and F. V. Chisari. 1996. Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients. J. Virol. 70:7092.
46. Carmichael, A., X. Jin, P. Sissons, and L. Borysiewicz. 1993. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J. Exp. Med. 177:249.
47. Zinkernagel, R. M., and H. Hengartner. 1994. T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS. Immunol. Today 15:262.
48. Van Parijs, L., A. Ibraghimov, and A. K. Abbas. 1996. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4:321.
49. Alexander-Miller, M. A., G. R. Leggatt, and J. A. Berzofsky. 1996 Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA 93:4102.