Evidence for common structural determinants of human immunodeficiency virus type 1 coreceptor activity provided through functional analysis of CCR5/CXCR4 chimeric coreceptors

Journal of Virology

Volumn 75, Issue 23, 2001, Pages 11503-11514

  Pontow, S ^a   Ratner, L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; VIRUS GLYCOPROTEIN; VIRUS RECEPTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; ASTROCYTOMA; CELL FUSION; CHIMERA; DNA FLANKING REGION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRUS ENVELOPE; VIRUS STRAIN;

AMINO ACID SEQUENCE; CELL LINE; HETEROCYCLIC COMPOUNDS; HIV-1; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, CCR5; RECEPTORS, CXCR4; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035172753     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.23.11503-11514.2001     Document Type: Article

References (51)

1. CC chemokine receptor 5-mediated signaling and HIV-1 coreceptor activity share common structural determinants. Critical residues in the third extracellular loop support HIV-1 fusion
2. HIV and SIV gp120 binding does not predict coreceptor function
3. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
4. Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein
5. Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses
6. Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities
7. Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity
8. Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry
9. N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates
10. Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates
11. Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by super-infection of nonproductively infected cell lines with recombinant luciferase-encoding viruses
12. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals
13. Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists
14. Beyond receptor expression: The influence of receptor conformation, density, and affinity in HIV-1 infection
15. HIV-1 membrane fusion: Targets of opportunity
16. Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1
17. Identification of CXCR4 domains that support coreceptor and chemokine receptor functions
18. Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry
19. Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4
20. HIV-1 entry and macrophage inflammatory protein-1 beta-mediated signaling are independent functions of the chemokine receptor CCR5
21. A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5
22. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
23. A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry
24. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
25. Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor
26. Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity
27. The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins
28. A biosensor assay for studying ligand-membrane receptor interactions: Binding of antibodies and HIV-1 Env to chemokine receptors
29. Relationship between productive HIV-1 infection of macrophages and CCR5 utilization
30. Analysis of the critical domain in the V3 loop of human immunodeficiency virus type 1 gp120 involved in CCR5 utilization
31. Entry of R5.X4 and X4 human immunodeficiency virus type 1 strains is mediated by negatively charged and tyrosine residues in the amino-terminal domain and the second extracellular loop of CXCR4
32. Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses
33. Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100
34. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines
35. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function
36. Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains
37. Changing virus-host interactions in the course of HIV-1 infection
38. Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants
39. Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation
40. Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1
41. Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity
42. In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
43. T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1 alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use
44. Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease
45. The HTLV receptor is a widely expressed protein
46. HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4
47. CCR5 HIV-1 coreceptor activity. Role of cooperativity between residues in N-terminal extracellular and intracellular domains
48. CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins
49. Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes
50. Interaction of chemokine receptor CCR5 with its ligands: Multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding
51. Constitutive cell surface association between CD4 and CCR5