Calcitonin gene-related peptide (CGRP) and the pathophysiology of headache: Therapeutic implications

CNS Drugs

Volumn 15, Issue 10, 2001, Pages 745-753

  Edvinsson, L ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMIGRAINE AGENT; BIBN 4096 BS; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; NEUROPEPTIDE; NEUROTRANSMITTER; SB 273779; UNCLASSIFIED DRUG;

BRAIN BLOOD VESSEL; CLUSTER HEADACHE; DISEASE CLASSIFICATION; DRUG STRUCTURE; HEADACHE; HUMAN; MIGRAINE; NEUROTRANSMITTER RELEASE; PATHOPHYSIOLOGY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN SECRETION; REVIEW; SENSORY NERVE; STRUCTURE ANALYSIS; TRIGEMINUS NEURALGIA;

EID: 0035170345     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200115100-00001     Document Type: Review

References (49)

1. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
2. Central nervous binding sites for calcitonin and calcitonin gene-related peptide
3. Calcitonin gene-related peptide: Vasoactive effects and potential therapeutic role
4. Calcitonin gene-related peptide (CGRP): Perivascular distribution and vasodilatory effects
5. The CGRP family: Calcitonin gene-related peptide (CGRP), amylin and adrenomedullin
6. Functional role of perivascular peptides in the control of the cerebral circulation
7. Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: Trigeminal origin and co-existence with substance P
8. Release of vasoactive peptides in the extracerebral circulation of man and the cat during activation of the trigeminovascular system
9. Calcitonin gene-related peptide is released from capsaicin-sensitive nerve fibres and induces vasodilation of human cerebral arteries concomitant with activation of adenylyl cyclase
10. Cerebrovascular responses to capsaicin in vitro and in situ
11. Aspects on the pathophysiology of migraine and cluster headache
12. Calcitonin gene-related peptide: Functional role in cerebrovascular regulation
13. Peptide-containing nerve fibers in human cerebral arteries: Immunohistochemistry, radio-immunoassay and in vitro pharmacology
14. 8.37 antagonizes the cerebral dilator response from nasociliary nerve stimulation in the cat
15. Neuronal messengers in the human cerebral circulation
16. Experimental studies on headaches, pain sensitive structures of the head and their significance in headaches
17. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
18. The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
19. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies
20. Retrograde tracing of nerve fibers to the rat middle cerebral artery with true blue: Colocalization with different peptides
21. Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally
22. Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack
23. Responsiveness of the trigeminovascular system to nitroglycerine in cluster headache patients
24. Cutaneous sensory stimulation leading to facial flushing and release of calcitonin gene-related peptide
25. Neuropeptide changes in a case of chronic paroxysmal hemicrania: Eidence for trigeminoparasympathetic activation
26. Calcitonin generelated peptide receptor antagonist human CGRP(8-37)
27. Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence of receptor multiplicity
28. Comparative affinities and antagonistic potencies of various human calcitonin gene-related peptide fragments on calcitonin gene-related peptide receptors in brain and periphery
29. Calcitonin gene-related peptide (hCGRP alpha) binding sites in the nucleus accumbens. Atypical structural requirements and marked phylogenic differences
30. Limitations in using peptide drugs to characterize calcitonin gene-related peptide receptors
31. A cDNA encoding the calcitonin gene-related peptide type I receptor
32. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
33. RAMPs: Accessory proteins for seven transmembrane domain receptors
34. Visualization of the calcitonin receptor-like receptor and its receptor activitymodifying proteins during internalization and recycling
35. Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor
36. Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product
37. Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay
38. CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors
39. Amylin: Localization, effects on cerebral arteries and on local cerebral blood flow in the cat
40. 1 receptors in the guinea pig basilar artery
41. Expression of calcitonin gene-related peptide 1 receptor mRNA in human trigeminal ganglia and cerebral arteries
42. Messenger molecules and receptor mRNA in the human tfigeminal ganglion
43. Expression of calcitonin receptor-like receptor (CRLR) and receptor-activity-modifying proteins in human cranial arteries
44. Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist
45. Characterization of the effects of a non-peptide CGRP receptor antagonist in SK-N-MC cells and isolated human cerebral arteries
46. Blockade and reversal of spinal morphine tolerance by peptide and non-peptide calcitonin gene-related peptide receptor antagonists
47. 2.7]hCGRP-preferring receptor
48. Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist
49. 1D receptors in the human trigeminal ganglion: Co-localization with calcitonin gene-related peptide, substance P and nitric oxide synthase