The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication

Mutation Research - DNA Repair

Volumn 408, Issue 2, 1998, Pages 103-110

  Barrows, Louis R ^a   Holden, Joseph A ^b   Anderson, Melvin ^c   D'Arpa, Peter ^c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c Uniformed Services University of the Health Sciences   (United States)

Author keywords

Aphidicolin; Camptothecin cytotoxicity; DNA ligase III; EM9; XRCC1

Indexed keywords

APHIDICOLIN; CAMPTOTHECIN; DNA TOPOISOMERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL MUTANT; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; DNA REPLICATION; DRUG SENSITIVITY; ENZYME DEFICIENCY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APHIDICOLIN; BLOTTING, WESTERN; CAMPTOTHECIN; CELL SURVIVAL; CHO CELLS; CRICETINAE; DNA LIGASES; DNA REPLICATION; DNA TOPOISOMERASES, TYPE I; DNA-BINDING PROTEINS; GENE DELETION; MUTATION; S PHASE;

EID: 0031927973     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(98)00022-6     Document Type: Article

References (42)

1. D.D. Von Hoff, H.A. Burris III, J. Eckardt, M. Rothenberg, S.M. Fields, S.-F. Chen, J.G. Kuhn, Preclinical and phase I trials of topoisomerase I inhibitors, Chemother. Pharmacol. 34 (1994) S41-S45.
2. P. Pantazis, B.C. Giovanella, M.L. Rothenberg, The camptothecins from discovery to the patient, Ann. New York Acad. Sci. (1996) 803.
3. L.H. Li, T.J. Fraser, E.J. Olin, B.K. Bhuyan, Action of camptothecin on mammalian cells in culture, Cancer Res. 32 (1972) 2643-2650.
4. J.C. Wang, DNA topoisomerases, in: C.C. Richardson, J.N. Abelson, C.R. Raetz (Eds.), Ann. Rev. Biochem., Annual Reviews, Palo Alto, CA, 1996, pp. 635-692.
5. J. Campoux, Evidence for an intermediate with a single-strand break in the reaction catalyzed by the DNA untwisting enzyme, P.N.A.S. 73 (1976) 3488-3491.
6. P. D'Arpa, P.S. Machlin, H.I. Ratrie, N.F. Rothfield, D.W. Cleveland, W.C. Earnshaw, cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment, Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 2543-2547.
7. Y.-H. Hsiang, R. Hertzberg, S. Hecht, L.F. Liu, Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I, J. Biol. Chem. 260 (1985) 14873-14878.
8. L.M. Covey, C. Jaxel, K.W. Kohn, Y. Pommier, Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I, Cancer Res. 49 (1989) 5016-5022.
9. P.M.J. Burgers, Eukaryotic DNA polymerases α and δ: conserved properties and interactions, from yeast to mammalian cells, Prog. Nucleic Acids Res. Mol. Biol. 37 (1989) 235-280.
10. Y.-H. Hsiang, M.G. Lihou, L.F. Liu, Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin, Cancer Res. 49 (1989) 5077-5082.
11. P. D'Arpa, C. Beardmore, L.F. Liu, Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons, Cancer Res. 50 (1990) 6919-6924.
12. C. Holm, J.M. Covey, D. Kerrigan, Y. Pommier, Differential requirement of DNA replication for the cytotoxicity of CAN topoisomerase I and II inhibitors in Chinese hamster DC3F cells, Cancer Res. 49 (1989) 6365-6368.
13. L.H. Thompson, J.S. Rubin, J.E. Cleaver, G.F. Whitmore, K. Brookman, A screening method for isolating DNA repair-deficient mutants of CHO cells, Somatic Cell Genet. 6 (1980) 391-405.
14. L.H. Thompson, K.W. Brookman, L.E. Dillehay, A.V. Carrano, L. Mazrimas, C.L. Mooney, J.L. Minkler, A CHO cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange, Mutat. Res. 95 (1982) 427-440.
15. L.H. Thompson, K.W. Brookman, N.J. Jones, S.A. Allen, A.V. Carrano, Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand-break repair and sister chromatid exchange, Mol. Cell. Biol. 10 (1990) 6160-6171.
16. K. Caldecott, P. Jeggo, Cross-sensitivity of γ-ray-sensitive hamster mutants to cross-linking agents, Mutat. Res. 255 (1991) 111-121.
17. P.A. Jeggo, K. Caldecott, S. Pidsley, G.R. Banks, Sensitivity of Chinese hamster ovary mutants defective in DNA double strand break repair to topoisomerase II inhibitors, Cancer Res. 49 (1989) 7057-7063.
18. L.M. Kemp, S.G. Sedgwick, P.A. Jeggo, X-Ray sensitive mutants of Chinese hamster ovary cells defective in double strand break rejoining, Mutat. Res. 132 (1984) 189-196.
19. K.W. Caldecott, C.K. McKeown, J.D. Tucker, S. Ljungquist, L.H. Thompson, An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III, Mol. Cell. Biol. 14 (1994) 68-76.
20. K.W. Caldecott, J.D. Tucker, L.H. Stanker, L.H. Thompson, Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells, Nucleic Acids Res. 23 (1995) 4836-4843.
21. T. Lindahl, C. Prigent, D.E. Barnes, A.R. Lehmann, M.S. Satoh, E. Roberts, R.A. Nash, P. Tobins, G. Daly, DNA joining in mammalian cells, C.S.H. Symp. Quant. Biol. 58 (1993) 619-624.
22. J.M. Juenke, J.A. Holden, The distribution of DNA topoisomerase II isoforms in differentiated adult mouse tissues, Biochim. Biophys. Acta 1216 (1993) 191-196.
23. 6-guanine alkylation, Carcinogenesis 8 (1987) 1853-1859.
24. I.B. Bronstein, A. Vorobyev, A. Timofeev, C.J. Jolles, S.L. Alder, J.A. Holden, Elevations of DNA topoisomerase I catalytic activity and immunoprecipitation in human malignancies, Oncol. Res. 8 (1996) 17-25.
25. J. Whyte, W.C. Barnshaw, J.J. Champoux, L.H. Parker, L. Stewart, N.D. Hall, Detection of anti-topoisomerase I antibodies using a full length human topoisomerase I recombinant protein purified from a baculovirus expression system, Clin. Exp. Immunol. 100 (1995) 214-218.
26. L.R. Barrows, M.B. Paxton, K.A. Kennedy, L.H. Thompson, XRCC1 gene expression and phenotypes of revertant EM9 (CHO) cell lines, Carcinogenesis 12 (1991) 805-811.
27. S. Squires, A.J. Ryan, H.L. Strutt, P.J. Smith, R.T. Johnson, Deoxyguanosine enhances the cytotoxicity of the topoisomerase I inhibitor camptothecin by reducing the repair of double strand breaks induced in replicating DNA, J. Cell Sci. 100 (1991) 883-893.
28. A.J. Ryan, S. Squires, H.L. Strutt, R.T. Johnson, Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA, Nucleic Acids Res. 19 (1991) 3295-3300.
29. F. Cortes, J. Pinero, T. Ortiz, Importance of replication fork progression for the induction of chromosome damage and SCE by inhibitors of DNA topoisomerases, Mutat. Res. 303 (1993) 71-76.
30. J.M. Coll, R.J. Hickey, Y. Wei, L.H. Malkas, The human cell multiprotein DNA replication complex (MRC): the effect of camptothecin on its ability to support in vitro DNA synthesis, Cancer Chemother. Pharmacol. 39 (1996) 97-102.
31. 1 /S cell blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis, J. Neurosci. 17 (1997) 1256-1270.
32. J.L. Nitiss, J.-C. Wang, Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA, Mol. Pharmacol. 50 (1996) 1095-1102.
33. P.M. O'Connor, N.W. Nieves, D. Kerrigan, R. Bertrand, J. Goldman, K.W. Kohn, Y. Pommier, S-phase population analysis does not correlate with the cytotoxicity of camptothecin and 10,11-methylenedioxycamptothecin in human colon carcinoma HT-29 cells, Cancer Commun. 3 (1991) 233-240.
34. 2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells, Cancer Res. 56 (1996) 4430-4437.
35. W. Voigt, S. Matsui, M. Yin, L. Silver, W. Burhans, Y. Rustum, Cytotoxic effects of topoisomerase I inhibitor (TI), SN-38, are associated with replication-dependent and independent DNA damage, Proc. Assoc. Cancer Res. 38, 16.
36. S. Matsui, W. Endo, C. Wrzosek, K. Haridas, S. Peddiahgari, F. Hausheer, Y. Rustum, A new DNA topoisomerase I inhibitor (TI), BNPI 1100, induces cytotoxicity through a dual mechanism in HCT-8 human ileocecal carcinoma cells, Proc. Assoc. Cancer Res. 38, 17.
37. L.H. Li, T.J. Fraser, E.J. Olin, B.K. Bhuyan, Action of camptothecin on mammalian cells in culture, Cancer Res. 32 (1972) 2643-2650.
38. E.J. Morris, H.M. Geller, Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase I: evidence for cell cycle-independent toxicity, J. Cell Biol. 3 (1996) 757-770.
39. J.M. Covey, C. Jaxel, K.W. Kohn, Y. Pommier, Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I, Cancer Res. 49 (1989) 5016-5022.
40. S.W. Yang, A.B. Burgin, B.N. Huizenga, C.A. Robertson, K.C. Yao, H.A. Nash, A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases, Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 11534-11539.
41. F. Palitti, F. Cortes, L. Bassi, D. Di Chiara, M. Fiore, J. Pinero, Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of topoisomerase I, Mutat. Res. 285 (1993) 281-285.
42. R. Silber, B. Degar, D. Costin, E.W. Newcomb, M. Mani, C.R. Rosenberg, L. Morse, J.C. Drygas, Z.N. Canellakis, M. Potmesil, Chemosensitivity of lymphocytes from patients with B cell chronic lymphocytic leukemia to chlorambucil, fludarabine, and camptothecin analogs, Blood 84 (1994) 3440-3446.