Frequent deletions and mutations of the β-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma

Clinical Cancer Research

Volumn 7, Issue 4, 2001, Pages 901-908

  Takayasu, Hajime ^a   Horie, Hiroshi ^b   Hiyama, Eiso ^b   Matsunaga, Tadashi ^b   Hayashi, Yutaka ^b   Watanabe, Yoshio ^b   Suita, Sachiyo ^b   Kaneko, Michio ^b   Sasaki, Fumiaki ^b   Hashizume, Kohei ^b   Ozaki, Toshinori ^a   Furuuchi, Keiji ^c   Tada, Mitsuhiro ^c   Ohnuma, Naomi ^b   Nakagawara, Akira ^a,b  

^a CHIBA CANCER CENTER   (Japan)

^b Japanese Study Group for Pediatric Liver Tumor   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BETA CATENIN; CYCLIN D1; FIBRONECTIN;

ADOLESCENT; ARTICLE; CANCER GROWTH; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; CORRELATION FUNCTION; EXON; GENE DELETION; GENE MUTATION; HEPATOBLASTOMA; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MAJOR CLINICAL STUDY; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL;

ADENOMATOUS POLYPOSIS COLI PROTEIN; BETA CATENIN; CELL DIFFERENTIATION; CHILD; CHILD, PRESCHOOL; CYCLIN D1; CYTOSKELETAL PROTEINS; FIBRONECTINS; GENE DELETION; HEPATOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; STATISTICS; TRANS-ACTIVATORS;

EID: 0034906471     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Primary hepatic tumors of childhood
2. Hepatoblastoma: The prognostic significance of histologic type
3. Loss of maternal alleles on chromosome 11p in hepatoblastoma
4. Loss of imprinting in hepatoblastoma
5. Expression, promoter usage and parental imprinting status of insulin-like growth factor 2 (IGF2) in human hepatoblastoma: Uncoupling of IGF2 and H19 imprinting
6. Promoter-specific insulin-like growth factor 2 gene imprinting in human fetal liver and hepatoblastoma
7. High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma
8. Hepatoblastoma in familial polyposis coli
9. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis
10. Risk of hepatoblastoma in familial adenomatous polyposis
11. Lessons from hereditary colorectal cancer
12. Genetic alterations during colorectal-tumor development
13. Inactivation of both APC alleles in an early stage on colon adenomas in a patient with familial adenomatous polyposis (FAP)
14. Somatic mutations of the APC gene in sporadic hepatoblastoma
15. Biallelic inactivation of the APC gene in hepatoblastoma
16. Childhood hepatoblastomas frequently carry a mutational degradation targeting box of the β-catenin gene
17. Activation of β-catenin in epithelial and mesenchymal hepatoblastomas
18. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-1- colon carcinoma
19. β-catenin as oncogene: The smoking gun
20. The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
21. β-catenin is a target for the ubiquitin-proteasome pathway
22. Nuclear localization of β-catenin by interaction with transcription factor LEF-1
23. Identification of connexin43 as a functional target for Wnt signaling
24. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic
25. A β-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
26. A cell-free assay system for β-catenin signaling that recapitulates direct inductive events in the early Xenopus leavis embryo
27. LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter
28. Identification of c-myc as a target of the APC pathway
29. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
30. The Wnt/Wg signal transducer β-catenin controls fibronectin expression
31. MYC oncogenes and human neoplastic disease
32. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma
33. Fibronectins: Multifunctional modular glucoproteins
34. A case of resection under the 4C-atrial venovenous bypass of a hepatoblastoma after intraarterial chemotherapy
35. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
36. Somatic mutations of the APC gene in primary breast cancers
37. Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
38. Mutational analysis of p51A/TAp63 γ, a p53 homolog, in non-small cell lung cancer and breast cancer
39. Mutational activation of the β-catenin proto-oncogene is a common event in the development of Wilms' tumors
40. β-catenin mutations in human prostate cancer
41. Frequent mutation and nuclear localization of β-catenin in anaplastic thyroid carcinoma
42. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
43. Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma
44. Overexpression of cyclin D1 and cdk4 in tumorigenesis of sporadic hepatoblastomas