Insulin-like growth factor-I and Bcl-XL inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis

Journal of Neurochemistry

Volumn 76, Issue 3, 2001, Pages 935-943

  Cheng, Hsin Lin ^a   Steinway, Matthew L ^a   Xin, Xiping ^a   Feldman, Eva L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Bcl XL; C jun N terminal protein kinase; Caspase; Insulin like growth factor I; Schwann cells

Indexed keywords

MEMBRANE PROTEIN; PROTEIN BCL X; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; MITOCHONDRIAL MEMBRANE; MYELINATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SCHWANN CELL; STIMULUS RESPONSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BCL-X PROTEIN; BLOOD PHYSIOLOGY; CASPASES; ENZYME ACTIVATION; INSULIN-LIKE GROWTH FACTOR I; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SCHWANN CELLS; SIGNAL TRANSDUCTION; TRANSFECTION;

ANIMALIA;

EID: 0035150245     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00110.x     Document Type: Article

References (74)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway
3. The activation of the c-June N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin
4. The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells
5. Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of June N-terminal kinase/p38 kinases and GADD153
6. Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve
7. Phosphatidylinositol 3-kinase and Akt protein kinase mediate IGF-I- and prosaptide-induced survival in Schwann cells
8. Activation of the c-June N-terminal kinase/stress-activated protein kinase pathway by overexpression of caspase-8 and its homologs
9. Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism
10. The role of c-jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation
11. Molecular mechanisms of c-June N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates
12. c-June N-terminal kinase mediates apoptotic signaling induced by N-(4-hydroxyphenyl) retinamide
13. Bi-directional regulation of p38 kinase and c-June N-terminal protein kinase by insulin-like growth factor-I
14. The Bcl-2 family of proteins, and the regulation of neuronal survival
15. Activation of June N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor alpha leads to intercellular adhesion molecule-1 expression
16. Insulin-like growth factor-I prevents caspase mediated apoptosis in Schwann cells
17. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-June activation domain
18. Defective T cell differentiation in the absence of Jnk1
19. Role of the June kinase pathway in the regulation of c-June expression and apoptosis in sympathetic neurons
20. A matter of life and cell death
21. Insulin-like growth factors regulate neuronal differentiation and survival
22. Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis
23. IGF-I receptor activation and Bcl-2 overexpression prevent early apoptotic events in human neuroblastoma
24. Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes
25. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
26. Selective interaction of JNK protein kinase isoforms with transcription factors
27. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling
28. A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death
29. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
30. L as an inhibitor of cytosolic cytochrome c accumulation in DNA damage-induced apoptosis
31. Insulin receptor substrate-2 and Shc play different roles in insulin-like growth factor-I signaling
32. Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-I-mediated cytoskeletal reorganization
33. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
34. The mitochondrial death/life regulator in apoptosis and necrosis
35. The stress-activated protein kinase subfamily of c-June kinases
36. The stress-activated protein kinases
37. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
38. 2-terminal kinase (JNK/SAPK)
39. Tyrosine phosphorylation of paxillin and focal adhesion kinase during insulin-like growth factor-I-stimulated lamellipodial advance
40. IGFs and the nervous system
41. Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death
42. Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells
43. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
44. Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-June N-terminal kinase
45. Bcl-xL blocks activation of related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2 and stress-activated protein kinase/c-June N-terminal protein kinase in the cellular response to methylmethane sulfonate
46. Activation of c-June N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2
47. Ordering the cell death pathway
48. Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons
49. The June kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin
50. Sphigomyelin-derived lipids differently regulate the extracellular signal-regulated kinase 2 (ERK2) and c-jun N-terminal kinase (JNK) signal cascades in airway smooth muscle
51. Multiple agents resue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms
52. Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal
53. Neurons undergo apoptosis in animal and cell culture models of diabetes
54. Lack of c-June activity increases survival to cisplatin
55. Bcl-2 family proteins as ion-channels
56. Type I insulin-like growth factor receptor activation regulates apoptotic proteins
57. Insulin-like growth factor I receptor prevents apotosis and enhances neuroblastoma tumorigenesis
58. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2,3,6,7,8, and 10 in a caspase-9 dependent manner
59. Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway
60. Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-June NH(2)-terminal kinase activity, and apoptosis
61. The Schwann cell lineage: Embryonic and early postnatal development
62. Mitogen-activated protein kinase cascades and regulation of gene expression
63. Cell death in the Schwann cell lineage and its regulation by neuregulin
64. A role for insulin-like growth factor-I in the regulation of Schwann cell survival
65. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor
66. Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes
67. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
68. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange
69. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
70. Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-June N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells
71. Regulation of nuclear transcription factors by stress signals
72. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
73. Overexpression of bcl-xL protects astrocytes from glucose deprivation and is associated with higher glutathione, ferritin, and iron levels
74. Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes