Functional characterization of two splice variants of rat bad and their interaction with Bcl-w in sympathetic neurons

Molecular and Cellular Neuroscience

Volumn 17, Issue 1, 2001, Pages 97-106

  Hamnér, Susanne ^a   Arumäe, Urmas ^b   Li Ying, Yu ^b   Sun, Yun Fu ^b   Saarma, Mart ^b   Lindholm, Dan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL W; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MOLECULAR CLONING; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN VARIANT; RAT; SYMPATHETIC NERVE CELL;

ANIMALIA;

EID: 0035147546     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.2000.0905     Document Type: Article

References (41)

1. p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors
2. Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta
3. Yeast two-hybrid system to detect protein - Protein interactions with Rho GTPases
4. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
5. Single-step method of RNA isolation by guanididium thiocyanate-phenol-chloroform extraction
6. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
7. Cloning and expression of the programmed cell death regulator Bad in the rat brain
8. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
9. Cranial sensory neurons
10. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
11. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene
12. bcl-w, a novel member of the bcl-2 family, promotes cell survival
13. bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death
14. bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria
15. Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system
16. 2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis
17. Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members
18. Alternative splicing and programmed cell death
19. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
20. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
21. Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons
22. Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors
23. Bcl-w expression is increased in brain regions affected by focal cerebral ischemia in the rat
24. Bim: A novel member of the Bcl-2 family that promotes apoptosis
25. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth
26. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
27. Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant
28. Bcl-2 family proteins
29. The combination of bcl-2 expression and NgF-deprivation facilitates the selective destruction of BAD protein in living sympathetic neurons
30. Testicular degeneration in Bclw-deficient mice
31. Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
32. Differential expression of rat brain bcl-2 family proteins in development and aging
33. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
34. Bax promotes neuronal cell death and is down-regulated during the development of the nervous system
35. BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11
36. Overexpression of the cell death suppressor Bcl-w in ischemic brain: Implications for a neuroprotective role via the mitochondrial pathway
37. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
38. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
39. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-13-3 not BCL-X(L)
40. A novel splice variant of the cell death-promoting protein BAX
41. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3