Alternative splicing and programmed cell death

Proceedings of the Society for Experimental Biology and Medicine

Volumn 220, Issue 2, 1999, Pages 64-72

  Jiang, Zhi Hong ^a   Wu, Jane Y ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; GENE PRODUCT; PROTEINASE; RNA;

ALTERNATIVE RNA SPLICING; APOPTOSIS; CELL MATURATION; CELLULAR DISTRIBUTION; CONFERENCE PAPER; GENE EXPRESSION REGULATION; MOLECULAR DYNAMICS; PHAGOCYTOSIS; PROTEIN FAMILY; REGULATOR GENE; REGULATORY MECHANISM;

EID: 0032914182     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.1999.d01-11.x     Document Type: Conference Paper

References (69)

1. Kerr JF, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257, 1972.
2. Horvitz HR, Shaham S, Hengartner MO. The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harbor Symp Quat Biol 59:377-385, 1994.
3. Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell 88:347-354, 1997.
4. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462, 1995.
5. Zou H, Henzel WJ, Liu XS, Lutschg A, Wang XD. Apaf-1, a human protein homologous to C. elegans Ced-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90:405-413, 1997.
6. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme. Cell 75:641-652, 1993.
7. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J. Human ICE/Ced-3 protease nomenclature. Cell 87:171, 1996.
8. Smith CWJ, Patton JG, Nadal-Ginard B. Alternative splicing control of gene expression. Annu Rev Genet 23:527, 1989.
9. Maniatis T. Mechanisms of alternative pre-mRNA splicing. Science 251:33-34, 1991.
10. Rio DC. Splicing of pre-mRNA: Mechanism, regulation, and role in development. Curr Opin Genet Dev 3:574-584, 1993.
11. Black DL. Finding splice sites within a wilderness of RNA. RNA 1:763-771, 1995.
12. Moore JM, Query CC, Sharp PA. Splicing of precursor to messenger RNAs by the spliceosome. In: The RNA World. Gesteland RF, Atkins JF, Eds. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, pp303-358, 1993.
13. Krämer A. The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu Rev Biochem 65:367-409, 1996.
14. Reed R. Initial splice site recognition and base pairing during pre-mRNA splicing. Curr Opin Genet Dev 6:215-220, 1996.
15. Hengartner MO. Apoptosis: Ced-4 is a stranger no more. Nature 388:714-715, 1997.
16. Hengartner MO. Apoptosis: Death cycle and Swiss army knife. Nature 391:441-442, 1998.
17. Screaton GR, Xu XN, Olsen AL, Cowper AE, Tan R, McMichael AJ, Bell JL. LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. Proc Natl Acad Sci USA 94:4615-4619, 1997.
18. Screaton GR, Mongkolsapaya J, Xu XN, Cowper AE, McMichael AJ, Bell JI. TRICK2: A new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. Curr Biol 7:693-696, 1997.
19. Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science 276:111-113, 1997.
20. Ruberti G, Cascino I, Papoff G, Eramo A. Fas splicing, variants and their effect on apoptosis. Adv Exp Med Biol 406:125-134, 1996.
21. Cascino I, Fiucci G, Papoff G, Ruberti G. Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. J Immunol 154:2706-2713, 1995.
22. Cascino I, Papoff G, Maria D, Testi R, Ruberti G. Fas/Apo-1/CD95 receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis. J Immunol 156:13, 1996.
23. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM. Cloning of the chromosome breakpoint of neoplastic B cells with t(14; 18) chromosome translocation. Science 226:1097-1099, 1984.
24. Tsujimoto Y, Jaffe E, Cossman J, Gorham J, Nowell PC, Croce CM. Clustering of breakpoint on chromosome 11 in human B-cell neoplasms with the t(11; 14) chromosome translocation. Nature 315:340-343, 1985.
25. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3:614-620, 1997.
26. Reed JC. Double identity for proteins of the Bcl-1 family. Nature 387:773-776, 1997.
27. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ. Bcl-2 deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidney, and hypopigmented hair. Cell 75:229-240, 1993.
28. Farrow SN, Brown R. New members of the Bcl-2 family and their protein partner. Curr Opin Genet Dev 6:45-49, 1996.
29. Hegde R, Srinivasula SM, Ahmad M, Fermandes-Alnemri T, Alnemri ES. Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. J Biol Chem 273:7783-7786, 1998.
30. Tsujimoto Y, Croce C. Analysis of the structure, transcripts, and protein products of Bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 83:5214-5218, 1986.
31. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336, 1990.
32. Tanaka S, Saito K, Reed JC. Structure-function analysis of the Bcl-2 oncoprotein; addition of heterologous transmembrane domain portions of the Bcl-2b protein restores function as a regulator of cell survival. J Biol Chem 268:10920-10926, 1993.
33. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama KI, Negishi I, Senju S, Zhang Q, Fujii S, Loh Z. Massive cell death of immature hematopoietic cells and neurons in Bcl-x deficient mice. Science 267:1506-1510, 1995.
34. Grillot DAM, González-García M, Ekhterae D, Duan L, Inohara N, Ohta S, Seldin MF, Núñez G. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J Immunol 158:4750-4757, 1997.
35. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB. Bcl-x, a Bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74(4):597-608, 1993.
36. Fang W, Rivard JJ, Mueller DL, Behrens TW. Cloning and molecular characterization of mouse Bcl-x in B and T lymphocytes. J Immunol 153(10):4388-4398, 1994.
37. González-García M, Perez-Ballestero R, Ding LY, Duan L, Boise LH, Thompson CB, Núñez G. Bcl-xL is the major Bcl-x mRNA form expressed during murine development, and its product localizes to mitochondria. Development 120:3033-3042, 1994.
38. Shiraiwa N, Inohara N, Okaka S, Yuzaki M, Shoji S, Ohta S. An additional form of rat Bcl-x, Bcl-xβ, generated by an unspliced RNA, promotes apoptosis in promyeloid cells. J Biol Chem 271:13258, 1996.
39. Yang XF, Weber GF, Cantor H. A novel Bcl-x isoform connected to the T-cell receptor regulates apoptosis in T cells. Immunity 7:629-639, 1997.
40. Gibson L, Holmgreen SP, Huang DCS, Bernard O, Copeland NG, Jenkins NA, Sutherland GR, Baker E, Adams JM, Cory S. Bcl-w, a novel member of the Bcl-2 family, promotes cell survival. Oncogene 13:665-675, 1996.
41. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619, 1993.
42. O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DCS. Bim: A novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17:384-395, 1998.
43. Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM. Interaction of Ced-4 with Ced-3 and Ced-9: A molecular framework for cell death. Science 275:1122-1126, 1997.
44. James C, Gschmeissner S, Fraser A, Evan GL. Ced-4 induces chromatin condensation in S. pombe and is inhibited by direct physical association with Ced-9. Curr Biol 7:246-252, 1997.
45. Spector MS, Desnoyers S, Hoeppner DJ, Hengartner MO. Interaction between the C. elegans cell-death regulators Ced-9 and Ced-4. Nature 385:653-656, 1997.
46. Wu D, Wallen HD, Nunez G. Interaction and regulation of subcellular localization of Ced-4 by Ced-9. Science 275:1126-1129, 1997.
47. Wu W, Wallen HD, Inohara N, Nunez G. Interaction and regulation of the Caenorhabditis elegans death protease Ced-3 by Ced-4 and Ced-9. J Biol Chem 272:21449-21454, 1997.
48. Shaham S, Horvitz HR. An alternatively spliced C. elegans Ced-4 RNA encodes a novel cell death inhibitor. Cell 86:201-208, 1996.
49. Nicholson DW, Thornberry NA. Caspases: Killer proteases. Trends Biochem Sci 22:299-306, 1997.
50. Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan T. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92:501-509, 1998.
51. Alnemri ES, Fernandes-Alnemri T, Litwack G. Cloning and expression of four novel isoforms of human interleukin-1 β converting enzyme with different apoptotic activities. J Biol Chem 270:4312-4317, 1995.
52. Wang L, Miura M, Bergeron L, Zhu H, Yuan J. Ich-1, an Ice/Ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78(5):739-750, 1994.
53. Alnemri ES. Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases. J Cell Biochem 64:33-42, 1997.
54. Fernandes-Alnemri T, Litwack G, Alnemri ES. CPP32: A novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 β-converting enzyme. J Biol Chem 269:30761-30764, 1984.
55. Fernandes-Alnemri T, Litwack G, Alnemri ES. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res 55(13):2737-2742, 1995a.
56. Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G, Earnshaw WC, Litwack G, Alnemri ES. Mch3: A novel human apoptotic cysteine protease highly related to CPP32. Cancer Res 55(24):6045-6052, 1995b.
57. Cheng J, Zhou T, Liu C, Shapiro JP, Brauer MJ, Kiefer MC, Barr PJ, Mountz JD. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263:1759, 1994.
58. Papoff G, Cascino I, Eramo A, Starace G, Lynch DH, Ruberti G. An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro. J Immunol 156(12):4622-4630, 1996.
59. Curtis D, Lehmann R, Zamore PD. Translational regulation in development. Cell 81:171-178, 1995.
60. Shaw G, Kamen R. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selection mRNA degradation. Cell 46:659-667, 1986.
61. Ladner MB, Martin GA, Noble JA, Nikoloff DM, Tal R. Human CSF-1: Gene structure and alternative splicing of mRNA precursors. EMBO J 6:2693-2698, 1987.
62. Bingham PM, Chou TB, Mims I, Zachar Z. On/off regulation of gene expression at the level of splicing. Trends Genet 4:134, 1988.
63. Madhani H, Guthrie C. Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genet 28:1-26, 1994.
64. Berget SM. Exon recognition in vertebrate splicing. J Biol Chem 2:2411-2414, 1995.
65. Fu X-D. The superfamily of arginine/serine rich splicing factors. RNA 1:663-680, 1995.
66. Cáceres JF, Stamm S, Helfman DM, Krainer AR. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 265:1706-1709, 1994.
67. Mayeda A, Krainer AR. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 68:365-375, 1992.
68. Mayeda A, Helfman DM, Krainer AR. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol 13:2993-3001, 1993.
69. Utz PJ, Hottelet M, Venrooij WJV, Anderson P. Association of phosphorylated serine/arginine (SR) splicing factors with the U1-small ribonucleoprotein (snRNP) autoantigen complex accompanies apoptotic cell death. J Exp Med 187:547-560, 1998.