Conformational changes during kinesin motility

Current Opinion in Cell Biology

Volumn 13, Issue 1, 2001, Pages 19-28

  Schief, W R ^a   Howard, J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN; KIF1A; KINESIN; MOLECULAR MOTOR; MYOSIN; UNCLASSIFIED DRUG;

BINDING AFFINITY; BINDING SITE; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; DIMERIZATION; MICROTUBULE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN TRANSPORT; REVIEW;

EID: 0035146785     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00169-1     Document Type: Review

References (68)

1. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin
2. Structure of the actin-myosin complex and its implications for muscle contraction
3. Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: Visualization of the pre-power stroke state
4. Atomic structure of scallop myosin subfragment S1 complexed with MgADP: A novel conformation of the myosin head
5. Structural mechanism of muscle contraction
6. A FRET-based sensor reveals large ATP hydrolysis-induced conformational changes and three distinct states of the molecular motor myosin
7. Processivity of the motor protein kinesin requires two heads
8. Kinesin's processivity results from mechanical and chemical coordination between the ATP hydrolysis cycles of the two motor domains
9. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility
10. A new look at the microtubule binding patterns of dimeric kinesins
11. Structural change in the kinesin motor protein that drives motility
12. Structures of kinesin and kinesin-microtubule interactions
13. X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4
14. The way things move: Looking under the hood of molecular motor proteins
15. Myosin VI is an actin-based motor that moves backwards
16. The movement of kinesin along microtubules
17. Determinants of molecular motor directionality
18. Directional motility of kinesin motor proteins
19. Structural links to kinesin directionality and movement
20. Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein
21. A mutant of the motor protein kinesin that moves in both directions on microtubules
22. Motility of dimeric ncd on a metal-chelating surfactant: Evidence that ncd is not processive
23. Working strokes by single molecules of the kinesin-related ncd microtubule motor
24. Myosin-V is a processive actin-based motor
25. The kinetic mechanism of myosin V
26. Two-headed binding of a processive myosin to F-actin
27. Myosin-V stepping kinetics: A molecular model for processivity
28. Direct observation of processive movement by individual myosin V molecules
29. Molecular motors: Structural adaptations to cellular functions
30. Movement of microtubules by single kinesin molecules
31. Coupled chemical and mechanical reaction steps in a processive Neurospora kinesin
32. Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: Comparison with X-ray structure and implications for motility
33. Congruent docking of dimeric kinesin and ncd into three-dimensional electron cryomicroscopy maps of microtubule-motor ADP complexes
34. Nucleotide and loading rate-dependent switching of single- to double-loaded binding of kinesin
35. A processive single-headed motor: Kinesin superfamily protein KIF1A
36. 15 Resolution model of the monomeric kinesin motor, KIF1A
37. Mechanism of the single-headed processivity: Diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin
38. Single-molecule behavior of monomeric and heteromeric kinesins
39. Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice
40. The conformational cycle of kinesin
41. Force production by single kinesin motors
42. Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis
43. Three-dimensional cryoelectron microscopy of dimeric kinesin and ncd motor domains on microtubules
44. Nucleotide-dependent conformations of the kinesin dimer interacting with microtubules
45. Kinesin takes one 8-nm step for each ATP that it hydrolyzes
46. Mechanical and chemical properties of cysteine-modified kinesin molecules
47. Coupling of kinesin steps to ATP hydrolysis
48. Kinesin hydrolyses one ATP per 8-nm step
49. Single kinesin molecules studied with a molecular force clamp
50. Weak and strong states of kinesin and ncd
51. Kinesin's tail domain is an inhibitory regulator of the motor domain
52. Kinesin's IAK tail domain inhibits initial microtubule-stimulated ADP release
53. Searching for kinesin's mechanical amplifier
54. Solution structures of dimeric kinesin and ncd motors
55. Interacting head mechanism of microtubule-kinesin ATPase
56. The coiled-coil helix in the neck of kinesin
57. Kinetic mechanism of a monomeric kinesin construct
58. One-headed kinesin derivatives move by a nonprocessive, low-duty ratio mechanism unlike that of two-headed kinesin
59. Force and velocity measured for single kinesin molecules
60. Mechanics of single kinesin molecules measured by optical trapping nanometry
61. The force generated by a single kinesin molecule against an elastic load
62. The load dependence of kinesin's mechanical cycle
63. Temperature dependence of force, velocity, and processivity of single kinesin molecules
64. The mechanochemistry of molecular motors
65. The force exerted by a molecular motor
66. Single-molecule tracking of myosins with genetically engineered amplifier domains
67. The overall conformation of conventional kinesins studied by small-angle X-ray and neutron scattering
68. Structural comparison of dimeric EgS, Neurospora kinesin (Nkin) and Ncd head-Nkin neck chimera with conventional kinesin