Directional motility of kinesin motor proteins

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1496, Issue 1, 2000, Pages 117-127

  Woehlke, Günther ^a   Schliwa, Manfred ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Directionality; Kinesin; Microtubule; Molecular motor; Non claret disjunctional protein; Processivity

Indexed keywords

KINESIN; MOLECULAR MOTOR;

CRYSTAL STRUCTURE; KINETICS; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROCESSING; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA PROTEINS; HUMANS; KINESIN; KINETICS; MICROTUBULES; MODELS, BIOLOGICAL; MOLECULAR MOTOR PROTEINS; MOLECULAR SEQUENCE DATA; MOVEMENT; MUTATION; THERMODYNAMICS;

EID: 0034678121     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(00)00013-6     Document Type: Review

References (57)

1. Vale R.D., Fletterick R.J. The design plan of kinesin motors. Ann. Rev. Cell Dev. Biol. 13:1997;745-777.
2. McDonald H.B., Stewart R.J., Goldstein L.S. The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor. Cell. 63:1990;1159-1165.
3. Walker R.A., Salmon E.D., Endow S.A. The Drosophila claret segregation protein is a minus-end directed motor molecule. Nature. 347:1990;780-782.
4. Grummt M., Woehlke G., Henningsen U., Fuchs S., Schleicher M., Schliwa M. Importance of a flexible hinge near the motor domain in kinesin-driven motility. EMBO J. 17:1998;5536-5542.
5. Whittaker M., Wilson-Kubalek E.M., Smith J.E., Faust L., Milligan R.A., Sweeney H.L. A 35-Å movement of smooth muscle myosin on ADP release. Nature. 378:1995;748-751.
6. Jontes J.D., Wilson-Kubalek E.M., Milligan R.A. A 32° tail swing in brush border myosin I on ADP release. Nature. 378:1995;751-753.
7. Holmes K.C. The swinging lever-arm hypothesis of muscle contraction. Curr. Biol. 7:1997;R112-R118.
8. T.Q.P. Uyeda, M. Anson, M.A. Geeves, S.E. Kurzawa and D.J. Manstein, Myosin motors with artificial lever arms, EMBO J. 15 (1996) 6074.
9. Romberg L., Pierce D.W., Vale R.D. Role of the kinesin neck region in processive microtubule-based motility. J. Cell Biol. 140:1998;1407-1416.
10. Howard J., Hudspeth A.J., Vale R.D. Movement of microtubules by single kinesin molecules. Nature. 342:1989;154-158.
11. Svoboda K., Schmidt C.F., Schnapp B.J., Block S.M. Direct observation of kinesin stepping by optical trapping interferometry. Nature. 365:1993;721-727.
12. Howard J. The movement of kinesin along microtubules. Annu. Rev. Physiol. 58:1996;703-729.
13. Coppin C.M., Pierce D.W., Hsu L., Vale R.D. The load dependence of kinesin's mechanical cycle. Proc. Natl. Acad. Sci. USA. 94:1997;8539-8544.
14. Mazumdar M., Cross R.A. Engineering a lever into the kinesin neck. J. Biol. Chem. 273:1998;29352-29359.
15. Hoenger A., Sablin E.P., Vale R.D., Fletterick R.J., Milligan R.A. Three-dimensional structure of a tubulin-motor-protein complex. Nature. 376:1995;271-274.
16. Jiang W., Stock M.F., Li X., Hackney D.D. Influence of the kinesin neck domain on dimerization and ATPase kinetics. J. Biol. Chem. 272:1997;7626-7632.
17. Hoenger A., Sack S., Thormahlen M., Marx A., Muller J., Gross H., Mandelkow E. Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: comparison with X-ray structure and implications for motility. J. Cell Biol. 141:1998;419-430.
18. Okada Y., Hirokawa N. A processive single-headed motor kinesin superfamily protein KIF1A. Science. 283:1999;1152-1157.
19. Hackney D.D. Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis. Proc. Natl. Acad. Sci. USA. 91:1994;6865-6869.
20. Ma Y.Z., Taylor E.W. Interacting head mechanism of microtubule-kinesin ATPase. J. Biol. Chem. 272:1997;724-730.
21. Moyer M.L., Gilbert S.P., Johnson K.A. Pathway of ATP hydrolysis by monomeric and dimeric kinesin. Biochemistry. 37:1998;800-813.
22. Lockhart A., Cross R.A. Origins of reversed directionality in the ncd molecular motor. EMBO J. 13:1994;751-757.
23. Crevel I.M., Lockhart A., Cross R.A. Weak and strong states of kinesin and ncd. J. Mol. Biol. 257:1996;66-76.
24. Pechatnikova E., Taylor E.W. Kinetic mechanism of monomeric non-claret disjunctional protein (ncd) ATPase. J. Biol. Chem. 272:1997;30735-30740.
25. Foster K.A., Correia J.J., Gilbert S.P. Equilibrium binding studies of non-claret disjunctional protein (ncd) reveal cooperative interactions between the motor domains. J. Biol. Chem. 273:1998;35307-35318.
26. Shimizu T., Toyoshima Y.Y., Edamatsu M., Vale R.D. Comparison of the motile and enzymatic properties of two microtubule minus-end-directed motors, ncd and cytoplasmic dynein. Biochemistry. 34:1995;1575-1582.
27. Shimizu T., Sablin E., Vale R.D., Fletterick R., Pechatnikova E., Taylor E.W. Expression, purification, ATPase properties, and microtubule-binding properties of the ncd motor domain. Biochemistry. 34:1995;13259-13266.
28. Lockhart A., Crevel M.-T.C., Cross R.A. Kinesin and ncd bind through a single head to microtubules and compete for a shared microtubule binding site. J. Mol. Biol. 249:1995;763-771.
29. Song H., Endow S.A. Binding sites on microtubules of kinesin motors of the same or opposite polarity. Biochemistry. 35:1996;11203-11209.
30. Walker R.A. ncd and kinesin motor domains interact with both α- and β-tubulin. Proc. Natl. Acad. Sci. USA. 92:1995;5960-5964.
31. Alonso M.C., van Damme J., Vandekerckhove J., Cross R.A. Proteolytic mapping of kinesin/ncd-microtubule interface: nucleotide-dependent conformational changes in the loops L8 and L12. EMBO J. 17:1998;945-951.
32. Mandelkow E., Hoenger A. Structures of kinesin and kinesin-microtubule interactions. Curr. Opin. Cell Biol. 11:1999;34-44.
33. Hirose K., Löwe J., Alonso M., Cross R.A., Amos L.A. Congruent docking of dimeric kinesin and ncd into three-dimensional electron cryomicroscopy maps of microtubule-motor ADP complexes. Mol. Biol. Cell. 10:1999;2063-2074.
34. Hirose K., Lockhart A., Cross R.A., Amos L.A. Nucleotide-dependent angular change in kinesin motor domain bound to tubulin. Nature. 376:1995;277-279.
35. Kikkawa M., Ishikawa T., Wakabayashi T., Hirokawa N. Three-dimensional structure of the kinesin head-microtubule complex. Nature. 376:1995;274-277.
36. Hoenger A., Milligan R.A. Motor domains of kinesin and ncd interact with microtubule protofilaments with the same binding geometry. J. Mol. Biol. 265:1997;553-564.
37. Hirose K., Cross R.A., Amos L.A. Nucleotide-dependent structural changes in dimeric NCD molecules complexed to microtubules. J. Mol. Biol. 274:1998;389-400.
38. Sosa H., Dias D.P., Hoenger A., Whittaker M., Wilson Kubalek E., Sablin E., Fletterick R.J., Vale R.D., Milligan R.A. A model for the microtubule-ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell. 90:1997;217-224.
39. Kozielski F., Arnal I., Wade R.H. A model of the microtubule-kinesin complex based on electron cryomicroscopy and X-ray crystallography. Curr. Biol. 8:1998;191-198.
40. Hirose K., Lockhart A., Cross R.A., Amos L.A. Three-dimensional cryoelectron microscopy of dimeric kinesin and ncd motor domains on microtubules. Proc. Natl. Acad. Sci. USA. 93:1996;9539-9544.
41. Arnal I., Metoz F., DeBonis S., Wade R.H. Three-dimensional structure of functional motor proteins on microtubules. Curr. Biol. 6:1996;1265-1270.
42. Arnal I., Wade R.H. Nucleotide-dependent conformations of the kinesin dimer interacting with microtubules. Structure. 6:1998;33-38.
43. Thormahlen M., Marx A., Muller S.A., Song Y., Mandelkow E.M., Aebi U., Mandelkow E. Interaction of monomeric and dimeric kinesin with microtubules. J. Mol. Biol. 275:1998;795-809.
44. Huang T.G., Hackney D.D. Drosophila kinesin minimal motor domain expressed in Escherichia coli. Purification and kinetic characterization. J. Biol. Chem. 269:1994;16493-16501.
45. Kull F.J., Sablin E.P., Lau R., Fletterick R.J., Vale R.D. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 380:1996;550-555.
46. Sablin E.P., Kull J.F., Cooke R., Vale R.D., Fletterick R.J. Crystal structure of the motor domain of the kinesin-related motor ncd. Nature. 380:1996;555-559.
47. Sack S., Muller J., Marx A., Thormahlen M., Mandelkow E.M., Brady S.T., Mandelkow E. X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry. 36:1997;16155-16165.
48. Sablin E.P., Case R.B., Dai S.C., Hart C.L., Ruby A., Vale R.D., Fletterick R.J. Direction determination in the minus-end-directed kinesin motor ncd. Nature. 395:1998;813-816.
49. Gulick A.M., Song H., Endow S.A., Rayment I. X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 Å resolution. Biochemistry. 37:1998;1769-1776.
50. Woehlke G., Ruby A.K., Hart C.L., Ly B., Hom Booher N., Vale R.D. Microtubule interaction site of the kinesin motor. Cell. 90:1997;207-216.
51. Alonso M.C., van Damme J., Vandekerckhove J., Cross R.A. Proteolytic mapping of kinesin/ncd-microtubule interface: nucleotide-dependent conformational changes in the loops L8 and L12. EMBO J. 17:1998;945-951.
52. Wriggers W., Schulten K. Nucleotide-dependent movements of the kinesin motor domain predicted by simulated annealing. Biophys. J. 75:1998;646-661.
53. Stewart R.J., Thaler J.P., Goldstein L.S.B. Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein. Proc. Natl. Acad. Sci. USA. 90:1993;5209-5213.
54. Case R.B., Pierce D.W., Hom Booher N., Hart C.L., Vale R.D. The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell. 90:1997;959-966.
55. Henningsen U., Schliwa M. Reversal in the direction of movement of a molecular motor. Nature. 389:1997;93-96.
56. U. Majdic, Thesis, Ludwig-Maximilian-University, Munich, 1999.
57. Endow S.A., Waligora K.W. Determinants of kinesin motor polarity. Science. 281:1998;1200-1202.