Structural links to kinesin directionality and movement

Nature Structural Biology

Volumn 7, Issue 6, 2000, Pages 456-460

  Wade, Richard H ^a   Kozielski, Frank ^a  

^a CEA GRENOBLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

KINESIN;

CELL MOTILITY; DIMERIZATION; HUMAN; MICROTUBULE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; KINESIN; MODELS, MOLECULAR; MOLECULAR MOTOR PROTEINS; MOLECULAR SEQUENCE DATA; MOVEMENT; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EUKARYOTA;

EID: 0034042578     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/75850     Document Type: Review

References (38)

1. Bloom, G.S. & Endow, S.A. Motor proteins I: kinesin. Protein profile 1. (Academic Press, London; 1995).
2. Greene, L., Henikoff, S. & Endow, S. The kinesin home page. http://blocks.fhcrc.org/kinesin (1999).
3. Okada, Y. & Hirokawa, N. Kinesin superfamily protein (KIF) home page. http://cb.m.u-tokyo.ac.jp/KIF (1998).
4. Coy, D.L., Hancock, W.O., Wagenbach, M. & Howard, J. Kinesin's tail domain is an inhibitory regulator of the motor domain. Nature Cell Biol. 1, 288-292 (1999).
5. Friedman, D.A. & Vale, R.D. Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain. Nature Cell Biol. 1, 293-297 (1999).
6. Stock, M.F., et al. Formation of the compact conformer of kinesin requires a C-terminal heavy chain domain and inhibits microtubule-stimulated ATPase activity. J. Biol. Chem. 274, 14617-14623 (1999).
7. Moore, J.D. & Endow, S.A. Kinesin proteins: a phylum of motors for microtubule-based motility. BioEssays 18, 207-219 (1996).
8. Hirokawa, N., Noda, Y. & Okada, Y. Kinesin and dynein superfamily proteins in organelle transport and cell division. Curr. Opin. Cell Biol. 10, 60-73 (1998).
9. Case, R.B., Pierce, D.W., Hom-Booher, N., Hart, C.L. & Vale, R.D. The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell 90, 959-966 (1997).
10. Henningsen, U. & Schliwa, M. Reversal in the direction of movement of a molecular motor. Nature 389, 93-95 (1997).
11. Endow, S.A. & Waligora, K.W. Determinants of kinesin motor polarity. Science 281, 1200-1202 (1998).
12. Rice, S., et al. A structural change in the kinesin motor protein that drives motility. Nature 402, 778-784 (1999).
13. Case, R.B., Rice, S., Hart, C.L., Ly, B. & Vale R.D. Role of the kinesin neck linker and the catalytic core in microtubule-based motility. Curr. Biol. 10, 157-160 (2000).
14. Kull, F.J., Sablin, E.P., Lau, R., Fletterick, R.J. & Vale, R.D. Crystal structure of the kinesin motor domain reveals a structural similarity to mysosin. Nature 380, 555-559 (1996).
15. Sablin, E.P., Kull, F.J., Cooke, R., Vale, R.D. & Fletterick, R.J. Crystal structure of the motor domain of the kinesin-related motor ncd. Nature 380, 550-555 (1996).
16. Vale, R.D. & Fletterick R.J. The design plan of kinesin motors. Annu. Rev. Cell Dev. Biol. 13, 745-777 (1997).
17. Gulick, A.M., Song, H., Endow, S.A. & Rayment I. X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 Å resolution. Biochemistry 37, 1769-1776 (1998).
18. Arnal, I., Metoz, F., DeBonis, S. & Wade, R.H. Three-dimensional structure of functional motor proteins on microtubules. Curr. Biol. 6, 1265-1270 (1996).
19. Hirose, K., Lockhart, A., Cross, R.A. & Amos, L.A. Three-dimensional cryoelectron microscopy of dimeric kinesin and ncd motor domains on microtubules. Proc. Natl. Acad. Sci. USA 93, 9539-9544 (1996).
20. Kozielski, F., et al. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell 91, 985-994 (1997).
21. Sablin, E.P., et al. Direction determination in the minus-end-directed kinesin motor ncd. Nature 395, 813-816 (1998).
22. Kozielski, F., De Bonis, S., Burmeister, W.P., Cohen-Addad, C. & Wade, R.H. The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations. Struct. Fold. Des. 7, 1407-1416 (1999).
23. Müller, J., Marx, A., Sack, S., Song, Y.-H. & Mandelkow, E. The structure of the nucleotide binding site of kinesin. Biol. Chem. 380, 981-992 (1999).
24. Sack, S. et al. X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry 36, 16155-16165 (1997).
25. Hirokawa, N. Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279, 519-526 (1998).
26. Endow, S.A. Determinants of molecular motor directionality. Nature Cell Biol. 1, E163-E167 (1999).
27. Ray, S., Meyhöfer E., Milligan, R.A. & Howard, J. Kinesin follows the microtubule's protofilament axis. J. Cell Biol. 121, 1083-1093 (1993).
28. Visscher, K., Schnitzer, M. & Block, S.M. Single kinesin molecules studied with a molecular force clamp. Nature 400, 184-189 (1999).
29. Coy, D.L., Wagenbach, M. & Howard, J. Kinesin takes one 8-nm step for each ATP that it hydrolyzes. J. Biol. Chem. 274, 3667-3671 (1999).
30. deCastro, M.J., Ho, C.-H. & Stewart R.J. Motility of ncd on a metal-chelating surfactant: evidence that ncd is not processive. Biochemistry 38, 5076-5081 (1999).
31. Foster, K.A. & Gilbert, S.P. Kinetic studies of dimeric ncd: evidence that ncd is not processive. Biochemistry 39, 1782-1791 (2000).
32. Hackney, D.D. The rate-limiting step in microtubule-stimulated ATP hydrolysis by dimeric kinesin head domains occurs while bound to the microtubule. J. Biol. Chem. 269, 16508-16511 (1994).
33. Hackney, D.D. Evidence for alternating head catalysis by kinesin during microtubule stimulated ATP hydrolysis. Proc. Natl. Acad. Sci. USA 91, 6865-6869 (1994).
34. Tripet, B., Vale, R.D. & Hodges, R.S. Demonstration of coiled-coil interactions within the kinesin neck region using synthetic peptides: implications for motor activity. J. Biol. Chem. 272, 8946-8956 (1997).
35. Romberg, L., Pierce, D.W. & Vale, R.D. Role of the kinesin neck region in processive microtubule-based motility. J. Cell Biol. 140, 1407-1416 (1998).
36. Naber, N., Cooke, R. & Pate, E. Binding of ncd to microtubules induces a conformational change near the junction of the motor domain with the neck. Biochemistry 36, 9681-9689 (1997).
37. Kikkawa, M., Okada, Y. & Hirokawa, N. 15 Å resolution model of the monomeric kinesin motor, KIFIA. Cell 100, 241-252 (2000).
38. Kraulis, P.J. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946-950 (1991).