Molecular genetics of essential hypertension: Recent results and emerging strategies

Current Opinion in Nephrology and Hypertension

Volumn 10, Issue 1, 2001, Pages 71-79

  Timberlake, David S ^a   O'Connor, Daniel T ^a   Parmer, Robert J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDUCIN; ADRENERGIC RECEPTOR; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN; ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE; GUANINE NUCLEOTIDE BINDING PROTEIN; KALLIKREIN; KININ; RENIN; SODIUM CHANNEL;

ADRENERGIC SYSTEM; BLOOD PRESSURE REGULATION; CATECHOLAMINERGIC SYSTEM; ESSENTIAL HYPERTENSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; HAPLOTYPE; HUMAN; KALLIKREIN KININ SYSTEM; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; CHROMOSOME MAPPING; GENETIC TECHNIQUES; GENOME; HUMANS; HYPERTENSION; LINKAGE (GENETICS); MOLECULAR BIOLOGY; PHENOTYPE;

EID: 0035138957     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200101000-00012     Document Type: Review

References (98)

1. Familial aggregation and genetic epidemiology of blood pressure
2. Genetic factors, family history, and blood pressure
3. Liddle's syndrome: Heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel
4. Molecular basis of human hypertension: Role of angiotensinogen
5. Association between the angiotensinogen 235T-variant and essential hypertension in whites: A systematic review and methodological appraisal
6. M235T angiotensinogen gene polymorphism and cardiovascular renal risk
7. Seven lessons from two candidate genes in human essential hypertension: Angiotensinogen and epithelial sodium channel
8. Haplotypes of angiotensinogen in essential hypertension
9. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro
10. Role of C/A polymorphism at - 20 on the expression of human angiotensinogen gene
11. Essential hypertension and 5′ upstream core promoter region of human angiotensinogen gene
12. Angiotensinogen gene and essential hypertension in the Japanese: Extensive association study and meta-analysis on six reported studies
13. The deletion/insertion polymorphism of the angiotensin converting enzyme gene cardiovascular-renal risk
14. Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males
15. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study
16. Sequence variation in the human angiotensin converting enzyme
17. Measured haplotype analysis of the angiotensin-I converting enzyme gene
18. Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase
19. Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2
20. Structural analysis and evaluation of the aldosterone synthase gene in hypertension
21. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function
22. Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction
23. Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction
24. Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure
25. Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London
26. Absence of linkage of the epithelial sodium channel to hypertension in black Caribbeans
27. Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension
28. Genetic linkage of beta and gamma subunits of epithelial sodium channel to systolic blood pressure
29. Linkage and association of adrenergic and dopamine receptor genes in the distal portion of the long arm of chromosome 5 with systolic blood pressure variation
30. Linkage of alpha-adrenergic pressor responsiveness to chromosome 5q in hypertensive families
31. Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings
32. 2-adrenergic receptor gene as a susceptibility locus for human hypertension
33. Beta-2 adrenergic receptor gene variations, blood pressure, and heart size in normal twins
34. Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor
35. Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression
36. Molecular and genetic basis of beta2-adrenergic receptor function
37. Beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals
38. Association of the G(s)alpha gene with essential hypertension and response to beta-blockade
39. Association of a human G-protein beta3 subunit variant with hypertension
40. G-Protein beta3 subunit C825T variant and ambulatory blood pressure in essential hypertension
41. 825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension
42. G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation
43. Plasma catecholamines and essential hypertension. An analytical review
44. Segregation and linkage analyses of dopamine-beta-hydroxylase activity in a six-generation pedigree
45. Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension
46. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat
47. Racial differences in renal kallikrein excretion: Effect of the ovulatory cycle
48. Hereditary intermediate phenotypes in African American hypertension
49. DNA polymorphisms in the 5′-flanking region of the human tissue kallikrein gene
50. Renal kallikrein excretion is associated with allelic variations in the human tissue kallikrein promoter on chromosome 19q in families with essential hypertension
51. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension
52. Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans
53. Association and linkage analysis of the alpha-adducin gene and blood pressure
54. Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations
55. Association between the alpha-adducin gene and hypertension in the HyperGEN Study
56. Alpha-adducin polymorphism in hypertensives of South African ancestry
57. All for one and one for all: Introduction to a coordinated analysis of the Gly-460-Trp alpha-adducin polymorphism. Family Blood Pressure Program
58. Association and linkage analysis of alpha-adducin polymorphism: Is the glass half full or half empty?
59. Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22
60. No linkage of the lipoprotein lipase locus to hypertension in Caucasians
61. Association of an apolipoprotein B gene marker with essential hypertension
62. Analysis of the apolipoprotein B3′ hypervariable region in patients with essential hypertension
63. Human prostacyclin synthase gene and hypertension: The Suita Study
64. Glucagon receptor gene mutation (Gly40Ser) in human essential hypertension: The PEGASE study
65. Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage
66. Association and linkage analyses of glucocorticoid receptor gene markers in essential hypertension
67. A genome-wide search for susceptibility loci to human essential hypertension
68. An extreme-sib-pair genome scan for genes regulating blood pressure
69. Mapping of a blood pressure quantitative trait locus to chromosome 15q in a Chinese population
70. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10
71. Preliminary evidence of linkage of salt sensitivity in black Americans at the beta 2-adrenergic receptor locus
72. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17
73. Linkage of the angiotensinogen gene to essential hypertension
74. Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans
75. Linkage of essential hypertension to the angiotensinogen locus in Mexican Americans
76. Heredity and the autonomic nervous system in human hypertension
77. Non-modulation as an intermediate phenotype in essential hypertension
78. Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity
79. Effects of gender and genotype on the phenotypic expression of nonmodulating essential hypertension
80. Increased urinary free cortisol: A potential intermediate phenotype of essential hypertension
81. Baroreflex sensitivity and heredity in essential hypertension
82. Chromogranin A in human hypertension. Influence of heredity
83. Catecholamine storage vesicle protein expression in genetic hypertension
84. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
85. Combined linkage and association sib-pair analysis for quantitative traits
86. A general test of association for quantitative traits in nuclear families
87. Transmission-disequilibrium tests for quantitative traits
88. New target regions for human hypertension via comparative genomics
89. Identification of quantitative trait loci for serum cholesterol levels in stroke-prone spontaneously hypertensive rats
90. Chromosomal mapping of quantitative trait loci that influence renal hemodynamic functions
91. Genome scan for blood pressure loci in mice
92. Drug firms to create public database of genetic mutations
93. Genetics of hypertension
94. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
95. Searching for genetic determinants in the new millennium
96. Pharmacogenetics and pharmacogenomics: Why is this relevant to the clinical geneticist?
97. Pharmacogenomics: Translating functional genomics into rational therapeutics