An extreme-sib-pair genome scan for genes regulating blood pressure

American Journal of Human Genetics

Volumn 64, Issue 6, 1999, Pages 1694-1701

  Xu, Xiping ^a,b   Rogus, John J ^c   Terwedow, Henry A ^c   Yang, Jianhua ^a   Wang, Zhaoxi ^c   Chen, Changzhong ^a   Niu, Tianhua ^c   Wang, Binyan ^c   Xu, Hengqiu ^a   Weiss, Scott ^c   Schork, Nicholas J ^c   Fang, Zhian ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; AUTOSOME; BLOOD PRESSURE REGULATION; CHINESE; CONTROLLED STUDY; FEMALE; GENETIC LINKAGE; GENETIC MARKER; GENETIC SCREENING; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SIBLING;

EID: 0033361891     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302405     Document Type: Article

References (26)

1. Blackwelder WC, Elston RC (1985) A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol 2:85-97
2. Buffone GJ, Darlington GJ (1985) Isolation of DNA from biological specimens without extraction with phenol. Clin Chem 31:164-165
3. Cardon LR, Fulker DW (1994) The power of interval mapping of quantitative trait loci, using selected sib pairs. Am J Hum Genet 55:825-833
4. Carey G, Williamson J (1991) Linkage analysis of quantitative traits: increased power by using selected samples. Am J Hum Genet 49:786-796
5. Chinese Academy of Preventive Medicine (1990) In: Chen J, Campbell TC, Li J, Peto R (eds) Diet, life-style and mortality in China: a study of the characteristics of 65 Chinese counties. Oxford University Press, London, pp 848-851
6. Frossard PM, Lestringant GG (1995) Association between a dimorphic site on chromosome 12 and clinical diagnosis of hypertension in three independent populations. Clin Genet 48:284-287
7. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, et al (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71:169-180
8. Julier C, Delepine M, Keavney B, Terwilliger J, Davis S, Weeks DE, Bui T, et al (1997) Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Hum Mol Genet 6:2077-2085
9. Holmans P (1993) Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Genet 52:362-374
10. Kruglyak I., Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified approach. Am J Hum Genet 58:1347-1363
11. Kruglyak L, Lander ES (1995a) Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454
12. _ (1995b) High-resolution genetic mapping of complex traits. Am J Hum Genet 56:1212-1223
13. Lander ES, Kruglyak I. (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
14. Lunetta KL, Rogus JJ (1998) A strategy for mapping minor histocompatibility genes involved in graft-versus-host disease: a novel application of discordant sib pair methodology. Genet Epidemiol 15:595-607
15. Olson JM (1997) When evidence in favor of linkage does not depend on disease. Am J Hum Genet Suppl 61:A289
16. Risch N (1990) Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 46:229-241
17. Risch N, Zhang H (1995) Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268:1584-1589
18. _ (1996) Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. Am J Hum Genet 58:836-843
19. Rogus JJ, Cai T, Wei L-J. Issues in genomic screening: critical values, sample sizes, and the ability to detect linkage. Genet Epidemiol (in press)
20. Rogus JJ, Harrington DP, Jorgenson E, Xu X (1997) Effectiveness of extreme discordant sib pairs to detect oligogenic disease loci. Genet Epidemiol 14:879-884
21. Schaid DJ (1996) General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 13:423-449
22. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516
23. Suarez BK, Hodge SE (1979) A simple method to detect linkage for rare recessive diseases: an application to juvenile diabetes. Clin Genet 15:126-136
24. Watt GC, Harrap SB, Foy CJ, Holton DW, Edwards HV, Davidson HR, Connor JM, et al (1992) Abnormalities of glucocorticoid metabolism and the renin angiotensin system: a four corners approach to the identification of genetic determinants of blood pressure. J Hypertens 10:473-482
25. Xu X, Niu T, Christiani DC, Weiss ST, Zhou Y, Chen C, Yang J, et al (1997) Environmental and occupational determinants of blood pressure in rural communities in China. Ann Epidemiol 7:95-106
26. Yuan B, Vaske D, Weber JL, Beck J, Sheffield VC (1997) Improved set of short-tandem-repeat polymorphisms for screening the human genome. Am J Hum Genet 60:459-460