Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors

Journal of Virology

Volumn 75, Issue 6, 2001, Pages 2929-2937

  Chen, H ^a   Lee, J M ^a   Zong, Y ^a   Borowitz, M ^a   Ng, M H ^a   Ambinder, R F ^a   Hayward, S D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; LATENT MEMBRANE PROTEIN 1; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

ARTICLE; BINDING SITE; CARCINOGENESIS; EPSTEIN BARR VIRUS; GENE CONTROL; GENE EXPRESSION; HODGKIN DISEASE; LONG TERMINAL REPEAT; LYMPHOBLASTOID CELL; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; VIRUS LATENCY;

CELL LINE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 4, HUMAN; HODGKIN DISEASE; HUMANS; NASOPHARYNGEAL NEOPLASMS; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; VIRAL MATRIX PROTEINS; VIRUS LATENCY;

EID: 0035123574     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.6.2929-2937.2001     Document Type: Article

References (63)

1. DNA methylation and the Epstein-Barr virus
2. The Epstein-Barr virus and its association with human cancers
3. Detection of Epstein-Barr virus in invasive breast cancers
4. STATs in oncogenesis
5. Stat3 as an oncogene
6. STAT3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription
7. Constitutive activation of JAK1 in Src-transformed cells
8. Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1
9. TEL-JAK2 transgenic mice develop T-cell leukemia
10. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
11. Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs
12. The Epstein-Barr virus latency Qp promoter is positively regulated by STATs and Zta interference with JAK-STAT activation leads to loss of Qp activity
13. Expression of Epstein-Barr virus Bam HI-A rightward transcripts (BARTs) in latently infected B cells from peripheral blood
14. Transcription of BamHI-A region of the EBV genome in NPC tissues and B cells
15. STATs and gene regulation
16. Control of inflammation, cytokine expression, and germinal center formation by BCL-6
17. Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: Role in NF-κB activation
18. Role of the TRAF binding site and NF-kappa B activation in Epstein-Barr virus latent membrane protein-induced cell gene expression
19. CD40-induced growth inhibition in epithelial ceils is mimicked by Epstein-Barr virus-encoded LMP1: Involvement of TRAF3 as a common mediator
20. Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappa B pathway involving TNF receptor-associated factors
21. Cell phenotype-dependent control of Epstein-Barr virus latent membrane protein 1 gent regulatory sequences
22. Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins
23. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
24. A fusion of the EBV latent membrane protein-1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor-kappa B, and stress-activated protein kinase
25. Modulation of interleukin-6 expression in Hodgkin and Reed-Sternberg cells by Epstein-Barr virus
26. Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL
27. Interleukin-6 signal transduction and lymphocyte function
28. The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappa B
29. The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-κB activation
30. Epstein-Barr virus and other candidate viruses in the pathogenesis of Hodgkin's disease
31. Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: Distinct STAT activation following surface Ig and CD40 receptor engagement
32. Epstein-Barr virus and its replication
33. STAT3 is required for the gp130-mediated full activation of the c-myc gene
34. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor
35. Genetic evidence that EBNA-1 is needed for efficient, stable latent infection by Epstein-Barr virus
36. Stat1 depends on transcriptional synergy with Sp1
37. Transcriptional regulation of the cyclin D1 promoter by STAT5: Its involvement in cytokine-dependent growth of hematopoietic cells
38. The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor
39. A novel form of Epstein-Barr virus latency in normal B cells in vivo
40. Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promotet in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein
41. Differential methylation of Epstein-Barr virus latency promoters facilitates viral persistence in healthy seropositive individuals
42. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region
43. Epstein-Barr virus
44. Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection
45. The Epstein-Barr virus 3.5-kilobase latent membrane protein 1 mRNA initiates from a TATA-less promoter within the first terminal repeat
46. Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group 1 Burkitt lymphoma cell lines
47. Transcriptional responses to polypeptide ligands: The Jak-Stat pathway
48. bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
49. STAT signaling in head and neck cancer
50. Negative regulation of the JAK/STAT pathway
51. Detection of Epstein-Barr virus (EBV) in hepatocellular carcinoma tissue: A novel EBV latency characterized by the absence of EBV-encoded small RNA expression
52. The human germinal centre cells, follicular dendritic cells and germinal centre T cells produce B cell-stimulating cytokines
53. Additive effect of Sp1 and Sp3 in regulation of the ED-L1E promoter of the EBV LMP 1 gene in human epithelial cells
54. Stat3 activation by Src induces specific gene regulation and is required for cell transformation
55. Mimicry of CD40 signals by EpsteinBarr virus LMP1 in B lymphocyte responses
56. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
57. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
58. Constitutive activation of Star proteins in primary lymphoid and myelold leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
59. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
60. Stable replication of plasmids derived from Epstein-Barr virus in a variety of mammalian cells
61. Enhanced DNA-binding activity of a Stat 3-related protein in cells transformed by the Src oncoprotein
62. Activation of Stat3 in v-Src transformed fibroblasts requires cooperation of Jak1 kinase activity
63. IFN-gamma induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: Functional interaction between an IFN-gamma-activated site and a GC-rich element